Combining Real-World and Randomized Control Trial Data Using Data-Adaptive Weighting via the On-Trial Score

Clinical trials with a hybrid control arm (a control arm constructed from a combination of randomized patients and real-world data on patients receiving usual care in standard clinical practice) have the potential to decrease the cost of randomized trials while increasing the proportion of trial pat...

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Veröffentlicht in:	arXiv.org 2021-08
Hauptverfasser:	Harton, Joanna, Segal, Brian, Mamtani, Ronac, Mitra, Nandita, Hubbard, Rebecca
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive control Bias Clinical trials Electronic health records Hybrid control Stability Statistical models
Online-Zugang:	Volltext
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