Role of postoperative adjuvant therapy in resected invasive intraductal papillary mucinous neoplasm of the pancreas: A multicenter external validation

Background Adjuvant therapy is beneficial in prolonging survival in patients with pancreatic ductal adenocarcinoma (PDAC). However, no clear guidelines are available on the oncologic effect of adjuvant therapy in resected invasive intraductal papillary mucinous neoplasms (inv‐IPMN). Methods In total, 551 patients with PDAC and 67 patients with inv‐IPMN of the pancreas were reviewed. For external validation, 46 patients with inv‐IPMN from six other Korean institutions were enrolled. Propensity score‐matched analysis and stage‐matched survival analysis were conducted. Results The mean follow‐up durations in the inv‐IPMN and PDAC groups were 43.36 months (SD, 42.34 months) and 43.35 months (SD, 35.62 months), respectively. The 5‐year overall survival (OS) was significantly better in the resected inv‐IPMN group than in the PDAC group in the overall stage‐matched analysis (P