Keratinocyte‐derived IL‐1β induces PPARG downregulation and PPARD upregulation in human reconstructed epidermis following barrier impairment

Peroxisome proliferator‐activated receptors (PPARs) are a family of nuclear hormone receptors. In skin, PPARs modulate inflammation, lipid synthesis, keratinocyte differentiation and proliferation and thus are important for skin barrier homeostasis. Accordingly, PPAR expression is altered in various...

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Veröffentlicht in:	Experimental dermatology 2021-09, Vol.30 (9), p.1298-1308
Hauptverfasser:	Blunder, Stefan, Krimbacher, Thomas, Moosbrugger‐Martinz, Verena, Gruber, Robert, Schmuth, Matthias, Dubrac, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone Atopic dermatitis Cells, Cultured Dermatology Down-Regulation epidermal barrier function Epidermis Epidermis - metabolism Homeostasis human epidermal equivalents Humans Interleukin-1beta - metabolism keratinocytes Keratinocytes - metabolism Life Sciences & Biomedicine nuclear hormone receptor Nuclear receptors Peroxisome proliferator-activated receptors Peroxisome Proliferator-Activated Receptors - metabolism PPAR Psoriasis Regular Science & Technology Skin Skin diseases Skin Diseases - metabolism Thymic stromal lymphopoietin Tumor necrosis factor-α Up-Regulation
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