Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women
Background: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D-binding protein (DBP). However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not associ...
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| Veröffentlicht in: | IOP conference series. Materials Science and Engineering 2017-03, Vol.180 (1), p.12281 |
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| creator | Sari, D K Tala, Z Z Lestari, Sri Hutagalung, S V Ganie, R A |
| description | Background: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D-binding protein (DBP). However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not associate with other bone health parameters. Objective:We sought to determine whether there is association between 25(OH)D 1) with bone health parameter differ by body weight; 2) Body mass index and BMD. Design: We conducted a cross-sectional observational study of 132 women aged 20-50 years in North Sumatera, Indonesia. Results: Serum total 25(OH)D was no different in normal, overweight, and obese women subjects (15.2±4.9 ng/mL). There was 77.3% categorized in deficiency and insufficiency (22.7%). There was no association among bone health parameters and body weight, but there is an association between BMD and body weight (p |
| doi_str_mv | 10.1088/1757-899X/180/1/012281 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_iop_j</sourceid><recordid>TN_cdi_proquest_journals_2563838845</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2563838845</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-1e79c771f6b33d5172e4b910a3a449d49071fcaa2c8f3edc0a8d987414ccb6f3</originalsourceid><addsrcrecordid>eNqFkEFLwzAYhoMoOKd_QQJe5qE2adMmPeqcbrA5cAO9hTRNsVvX1KZl9t-bWpkIgqd84XveN-EB4BKjG4wYczENqMOi6NXFDLnYRdjzGD4Cg8Pi-DAzfArOjNkgFFJC0ADwud5DLxgtp9f3cKWqZgcXooVPuobPKs2VrKGwY2a2cLVVuapFDqdK5PUbjJv6i9tn9nKnk9YmjYGzIlEfMCvgi96p4hycpCI36uL7HIL1w2Q9njrz5eNsfDt3JEG0drCikaQUp2Hs-0mAqadIHGEkfEFIlJAI2Z0UwpMs9VUikWBJxCjBRMo4TP0huOpry0q_N8rUfKObqrAvci8IfeYzRgJLhT0lK21MpVJeVtlOVC3HiHcueaeJd8q4dckx713a4KgPZrr8aV6sJr8wXibdT7w_0H_6PwGSioEe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2563838845</pqid></control><display><type>article</type><title>Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women</title><source>IOP Publishing Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>IOPscience extra</source><source>Free Full-Text Journals in Chemistry</source><creator>Sari, D K ; Tala, Z Z ; Lestari, Sri ; Hutagalung, S V ; Ganie, R A</creator><creatorcontrib>Sari, D K ; Tala, Z Z ; Lestari, Sri ; Hutagalung, S V ; Ganie, R A</creatorcontrib><description>Background: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D-binding protein (DBP). However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not associate with other bone health parameters. Objective:We sought to determine whether there is association between 25(OH)D 1) with bone health parameter differ by body weight; 2) Body mass index and BMD. Design: We conducted a cross-sectional observational study of 132 women aged 20-50 years in North Sumatera, Indonesia. Results: Serum total 25(OH)D was no different in normal, overweight, and obese women subjects (15.2±4.9 ng/mL). There was 77.3% categorized in deficiency and insufficiency (22.7%). There was no association among bone health parameters and body weight, but there is an association between BMD and body weight (p<0.05). Conclusions: Serum total 25(OH))D lower at all categorize body mass index, which cannot be explained by higher in adipocyte and lower in circulation or low DBP or shorter half-life of 25(OH)D. Lower 25(OH)D may not reflect at risk skeletal helath and higher BMI should be considered as a marker of higher BMD.</description><identifier>ISSN: 1757-8981</identifier><identifier>EISSN: 1757-899X</identifier><identifier>DOI: 10.1088/1757-899X/180/1/012281</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Adipocytes ; Body mass index ; Body size ; Body weight ; Parameters</subject><ispartof>IOP conference series. Materials Science and Engineering, 2017-03, Vol.180 (1), p.12281</ispartof><rights>Published under licence by IOP Publishing Ltd</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-1e79c771f6b33d5172e4b910a3a449d49071fcaa2c8f3edc0a8d987414ccb6f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1757-899X/180/1/012281/pdf$$EPDF$$P50$$Giop$$Hfree_for_read</linktopdf><link.rule.ids>314,777,781,27905,27906,38849,38871,53821,53848</link.rule.ids></links><search><creatorcontrib>Sari, D K</creatorcontrib><creatorcontrib>Tala, Z Z</creatorcontrib><creatorcontrib>Lestari, Sri</creatorcontrib><creatorcontrib>Hutagalung, S V</creatorcontrib><creatorcontrib>Ganie, R A</creatorcontrib><title>Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women</title><title>IOP conference series. Materials Science and Engineering</title><addtitle>IOP Conf. Ser.: Mater. Sci. Eng</addtitle><description>Background: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D-binding protein (DBP). However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not associate with other bone health parameters. Objective:We sought to determine whether there is association between 25(OH)D 1) with bone health parameter differ by body weight; 2) Body mass index and BMD. Design: We conducted a cross-sectional observational study of 132 women aged 20-50 years in North Sumatera, Indonesia. Results: Serum total 25(OH)D was no different in normal, overweight, and obese women subjects (15.2±4.9 ng/mL). There was 77.3% categorized in deficiency and insufficiency (22.7%). There was no association among bone health parameters and body weight, but there is an association between BMD and body weight (p<0.05). Conclusions: Serum total 25(OH))D lower at all categorize body mass index, which cannot be explained by higher in adipocyte and lower in circulation or low DBP or shorter half-life of 25(OH)D. Lower 25(OH)D may not reflect at risk skeletal helath and higher BMI should be considered as a marker of higher BMD.</description><subject>Adipocytes</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Parameters</subject><issn>1757-8981</issn><issn>1757-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkEFLwzAYhoMoOKd_QQJe5qE2adMmPeqcbrA5cAO9hTRNsVvX1KZl9t-bWpkIgqd84XveN-EB4BKjG4wYczENqMOi6NXFDLnYRdjzGD4Cg8Pi-DAzfArOjNkgFFJC0ADwud5DLxgtp9f3cKWqZgcXooVPuobPKs2VrKGwY2a2cLVVuapFDqdK5PUbjJv6i9tn9nKnk9YmjYGzIlEfMCvgi96p4hycpCI36uL7HIL1w2Q9njrz5eNsfDt3JEG0drCikaQUp2Hs-0mAqadIHGEkfEFIlJAI2Z0UwpMs9VUikWBJxCjBRMo4TP0huOpry0q_N8rUfKObqrAvci8IfeYzRgJLhT0lK21MpVJeVtlOVC3HiHcueaeJd8q4dckx713a4KgPZrr8aV6sJr8wXibdT7w_0H_6PwGSioEe</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Sari, D K</creator><creator>Tala, Z Z</creator><creator>Lestari, Sri</creator><creator>Hutagalung, S V</creator><creator>Ganie, R A</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope></search><sort><creationdate>20170301</creationdate><title>Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women</title><author>Sari, D K ; Tala, Z Z ; Lestari, Sri ; Hutagalung, S V ; Ganie, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-1e79c771f6b33d5172e4b910a3a449d49071fcaa2c8f3edc0a8d987414ccb6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Parameters</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sari, D K</creatorcontrib><creatorcontrib>Tala, Z Z</creatorcontrib><creatorcontrib>Lestari, Sri</creatorcontrib><creatorcontrib>Hutagalung, S V</creatorcontrib><creatorcontrib>Ganie, R A</creatorcontrib><collection>IOP Publishing Free Content</collection><collection>IOPscience (Open Access)</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><jtitle>IOP conference series. Materials Science and Engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sari, D K</au><au>Tala, Z Z</au><au>Lestari, Sri</au><au>Hutagalung, S V</au><au>Ganie, R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women</atitle><jtitle>IOP conference series. Materials Science and Engineering</jtitle><addtitle>IOP Conf. Ser.: Mater. Sci. Eng</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>180</volume><issue>1</issue><spage>12281</spage><pages>12281-</pages><issn>1757-8981</issn><eissn>1757-899X</eissn><abstract>Background: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D-binding protein (DBP). However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not associate with other bone health parameters. Objective:We sought to determine whether there is association between 25(OH)D 1) with bone health parameter differ by body weight; 2) Body mass index and BMD. Design: We conducted a cross-sectional observational study of 132 women aged 20-50 years in North Sumatera, Indonesia. Results: Serum total 25(OH)D was no different in normal, overweight, and obese women subjects (15.2±4.9 ng/mL). There was 77.3% categorized in deficiency and insufficiency (22.7%). There was no association among bone health parameters and body weight, but there is an association between BMD and body weight (p<0.05). Conclusions: Serum total 25(OH))D lower at all categorize body mass index, which cannot be explained by higher in adipocyte and lower in circulation or low DBP or shorter half-life of 25(OH)D. Lower 25(OH)D may not reflect at risk skeletal helath and higher BMI should be considered as a marker of higher BMD.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1757-899X/180/1/012281</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Body mass index Body size Body weight Parameters |
| title | Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women |
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