Efficient Synthesis of Polysubstituted Furans through a Base‐Promoted Oxacyclization of (Z)‐2‐En‐4‐yn‐1‐ols

An efficient base catalyzed oxacyclization of Z‐enynols has been developed under transition metal‐free reaction conditions, thus resulting in a variety of new di‐, tri‐, and tetra‐substituted furans. This approach allowed us to obtain 32 new compounds. Furthermore, DFT calculations were realized to...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of organic chemistry 2021-07, Vol.2021 (27), p.3798-3806
Hauptverfasser:	Hrizi, Asma, Thiery, Emilie, Romdhani‐Younes, Moufida, Jacquemin, Johan, Thibonnet, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Exo-dig oxacyclization Alkynols Furans Polysubstituted furans Synthesis Tandem coupling/oxacyclization Transition metals Transition-metal-free
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!