206-OR: RAGE-Dependent Macrophage Activation Aggravates Retrograde Axonal Transport via Attenuated Insulin Signaling of Peripheral Nerves in Experimental Diabetic Polyneuropathy

Advanced glycation end products (AGEs) activates its receptor, RAGE, resulting in a skewing of macrophage (Mϕ) polarity toward inflammatory phenotype (M1) and an impairment of the insulin signaling (IS) in adipose tissue. IS also regulates axonal transport (AT) in the peripheral nervous system. Alth...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2021-06, Vol.70 (Supplement_1)
Hauptverfasser:	OSONOI, SHO, MIZUKAMI, HIROKI, KUDO, KAZUHIRO, YAMAMOTO, YASUHIKO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Advanced glycosylation end products AKT protein Axonal transport Bone marrow Cell activation Diabetes Diabetes mellitus Dorsal root ganglia Glycosylation Immunofluorescence Inflammation Insulin Macrophages Nerve conduction Nervous system Peripheral nerves Phenotypes Phosphorylation Polarity Polyneuropathy Sciatic nerve Streptozocin Western blotting
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