Inhibition of Thiol‐Mediated Uptake with Irreversible Covalent Inhibitors

Thiol‐mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irreversible covalent inhibitors of thiol‐mediated uptake. High‐content high‐throughput screening of the so far largest collection of hypervalent iodine reagents affords inhibitors that are more than 250 ...

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Veröffentlicht in:	Helvetica chimica acta 2021-08, Vol.104 (8), p.n/a
Hauptverfasser:	Lim, Bumhee, Cheng, Yangyang, Kato, Takehiro, Pham, Anh‐Tuan, Le Du, Eliott, Mishra, Abhaya Kumar, Grinhagena, Elija, Moreau, Dimitri, Sakai, Naomi, Waser, Jerome, Matile, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Covalence hypervalent compounds hypervalent iodine reagents Inhibitors Iodine nosyl protecting group Pain Reagents thiol-mediated uptake TRPA1 pain receptor Viruses
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