Rosmarinic acid protects mice from imiquimod induced psoriasis‐like skin lesions by inhibiting the IL‐23/Th17 axis via regulating Jak2/Stat3 signaling pathway

IL‐23/Th17 (IL‐17) axis plays a critical role in psoriasis. Rosmarinic acid (RA) was proved the inhibitory effect of T cell infiltration in the skin. However, whether and how RA has beneficial effects on psoriasis did not really know yet. So lipopolysaccharide (LPS)‐induced abnormal proliferation Ha...

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Veröffentlicht in:	Phytotherapy research 2021-08, Vol.35 (8), p.4526-4537
Hauptverfasser:	Zhang, Miaomiao, Li, Ning, Cai, Ruhang, Gu, Jiangyong, Xie, Fuda, Wei, Hong, Lu, Chuanjian, Wu, Dinghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral drugs Cell differentiation Cell migration Cinnamates - pharmacology Cytokines Depsides - pharmacology Dermatitis Disease Models, Animal Flow cytometry HaCaT Cells Helper cells Histopathology Humans IL‐23/Th17 axis Imiquimod Inflammation Interleukin-23 - immunology Jak2/Stat3 signal pathway Janus Kinase 2 Langerhans cells Lesions Lipopolysaccharides Lymph nodes Lymphocytes Lymphocytes T Mice Mice, Inbred BALB C Polymerase chain reaction Psoriasis Psoriasis - chemically induced Psoriasis - drug therapy Reverse transcription Rosmarinic Acid Signal transduction Signal Transduction - drug effects Skin Skin diseases Skin lesions Stat3 protein STAT3 Transcription Factor Th17 Cells - cytology Western blotting
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