Levodopa challenge test: indications, protocol, and guide
A drug challenge test in Parkinson’s disease, such as the levodopa challenge test (LCT), is an easy and generally safe procedure, which has been used by clinicians for various indications. The results of the test have significant implications in the management of patients, from preoperative evaluati...
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| Veröffentlicht in: | Journal of neurology 2021-09, Vol.268 (9), p.3135-3143 |
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| container_end_page | 3143 |
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| container_title | Journal of neurology |
| container_volume | 268 |
| creator | Saranza, Gerard Lang, Anthony E. |
| description | A drug challenge test in Parkinson’s disease, such as the levodopa challenge test (LCT), is an easy and generally safe procedure, which has been used by clinicians for various indications. The results of the test have significant implications in the management of patients, from preoperative evaluation for deep brain stimulation to providing the basis for medication adjustments to address motor or non-motor fluctuations and dyskinesias. This paper reviews the different indications and protocols commonly used in an acute LCT. Potential complications of the procedure and an overview of levodopa responsiveness and unresponsiveness are also discussed. |
| doi_str_mv | 10.1007/s00415-020-09810-7 |
| format | Article |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Deep brain stimulation Dopamine Drug dosages Levodopa Medicine Medicine & Public Health Movement disorders Neurodegenerative diseases Neurology Neuroradiology Neurosciences Parkinson's disease Patients Review Surgery Tremor (Muscular contraction) |
| title | Levodopa challenge test: indications, protocol, and guide |
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