Genome-scale screens identify factors regulating tumor cell responses to natural killer cells

To systematically define molecular features in human tumor cells that determine their degree of sensitivity to human allogeneic natural killer (NK) cells, we quantified the NK cell responsiveness of hundreds of molecularly annotated ‘DNA-barcoded’ solid tumor cell lines in multiplexed format and app...

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Veröffentlicht in:	Nature genetics 2021-08, Vol.53 (8), p.1196-1206
Hauptverfasser:	Sheffer, Michal, Lowry, Emily, Beelen, Nicky, Borah, Minasri, Amara, Suha Naffar-Abu, Mader, Chris C., Roth, Jennifer A., Tsherniak, Aviad, Freeman, Samuel S., Dashevsky, Olga, Gandolfi, Sara, Bender, Samantha, Bryan, Jordan G., Zhu, Cong, Wang, Li, Tariq, Ifrah, Kamath, Govinda M., Simoes, Ricardo De Matos, Dhimolea, Eugen, Yu, Channing, Hu, Yiguo, Dufva, Olli, Giannakis, Marios, Syrgkanis, Vasilis, Fraenkel, Ernest, Golub, Todd, Romee, Rizwan, Mustjoki, Satu, Culhane, Aedin C., Wieten, Lotte, Mitsiades, Constantine S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191/2018 631/250/251 Agriculture Allogeneic Cells - physiology Animal Genetics and Genomics Animals Antigen presentation Antigens B7 Antigens - genetics Biomarkers Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cancer Research Cell Line, Tumor Chromatin Assembly and Disassembly - physiology Chromatin remodeling CRISPR Cytotoxicity Cytotoxicity Tests, Immunologic - methods Cytotoxicity, Immunologic - genetics Cytotoxicity, Immunologic - physiology Deoxyribonucleic acid DNA DNA barcoding Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Female Gene expression Gene Expression Regulation, Neoplastic Gene Function Genes Genetic aspects Genetic modification Genetic transcription Genome editing Genome, Human Genomes Genomics Histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology HLA-E Antigens Human Genetics Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - pharmacology Immunotherapy Killer cells Killer Cells, Natural - physiology Ligands Mesenchyme Methods Mice Mice, Inbred NOD Mutation Natural killer cells Oncology, Experimental Proteins Solid tumors Transcription Tumor cell lines Tumor cells Tumors Xenograft Model Antitumor Assays
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