Temporal changes in the markers of ribosome biogenesis in rat soleus muscle under simulated microgravity

Skeletal muscle inactivity due to real or simulated microgravity results in a significant atrophy of muscle fibers. One of the key causes of disuse atrophy is a decrease in the rate of muscle protein synthesis (MPS). MPS is dependent not only on translational efficiency but also on the number of rib...

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Veröffentlicht in:	Acta astronautica 2021-09, Vol.186, p.252-258
Hauptverfasser:	Rozhkov, Sergey V., Sharlo, Kristina A., Mirzoev, Timur M., Shenkman, Boris S.
Format:	Artikel
Sprache:	eng
Schlagworte:	18S+28S rRNA Atrophy Biomarkers Biosynthesis c-Myc Electrophoresis Gene expression Hindlimb unloading Microgravity Muscles Protein synthesis Ribosome biogenesis Soleus muscle Sunset Yeast
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