Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki-Miyaura cross-coupling reactions
A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki-Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered...
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| Veröffentlicht in: | RSC advances 2021-08, Vol.11 (43), p.26883-26891 |
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| container_issue | 43 |
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| container_title | RSC advances |
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| creator | Lamola, Jairus L Moshapo, Paseka T Holzapfel, Cedric W Maumela, Munaka Christopher |
| description | A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki-Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature.
Efficient palladium catalyst systems consisting of bench-stable biaryl phosphacycles and Pd(OAc)
2
are described for Suzuki-Miyaura cross-coupling reactions of a diverse array of aryl halides and arylboronic acids. |
| doi_str_mv | 10.1039/d1ra04947j |
| format | Article |
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Efficient palladium catalyst systems consisting of bench-stable biaryl phosphacycles and Pd(OAc)
2
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Efficient palladium catalyst systems consisting of bench-stable biaryl phosphacycles and Pd(OAc)
2
are described for Suzuki-Miyaura cross-coupling reactions of a diverse array of aryl halides and arylboronic acids.</description><subject>Bromides</subject><subject>Chemical reactions</subject><subject>Chemistry</subject><subject>Cross coupling</subject><subject>Crystallography</subject><subject>Ligands</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Palladium</subject><subject>Phosphines</subject><subject>Room temperature</subject><subject>Substrates</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkttrFDEUxgex2NL2xXdlwBcRRnO_vAil1mqpKF6eQybJ7GadTabJpLD-9U27dVvNywmcH1_Od740zXMI3kKA5TsLkwZEEr560hwgQFiHAJNPH933m-OcV6AeRiFi8FmzjykRAEB40MSzaz0WPfsY2ji037o-ebtwtu29TpuxnZYxT0sfXDv6hQ42tz60kx5HbX1Zd0bPetzkyv8of8pv333xG12Sbk2KOXcmlmn0YdEmp83tG_mo2Rv0mN3xfT1sfn08-3n6qbv8ev759OSyMwSJuZOIYG7hICTHZCDEMokgEZD1SPDBMGo4FYwj0SOqhXED5ExICylm2DCB8GHzfqs7lX7trHFhTnpUU_Lr6ktF7dW_neCXahGvlQSYMyirwOt7gRSvisuzWvtsXDUeXCxZIUYZJ1BSWNFX_6GrWFKo9hSiVBJIMBGVerOl7laT3LAbBgJ1G6X6AL-f3EV5UeGXj8ffoX-Dq8CLLZCy2XUf_gK-AbdXo9g</recordid><startdate>20210805</startdate><enddate>20210805</enddate><creator>Lamola, Jairus L</creator><creator>Moshapo, Paseka T</creator><creator>Holzapfel, Cedric W</creator><creator>Maumela, Munaka Christopher</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7633-3966</orcidid></search><sort><creationdate>20210805</creationdate><title>Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki-Miyaura cross-coupling reactions</title><author>Lamola, Jairus L ; Moshapo, Paseka T ; Holzapfel, Cedric W ; Maumela, Munaka Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-92437d1f89734f44d69214816b287fc65c7586728b25a8cef17689d15363c6823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bromides</topic><topic>Chemical reactions</topic><topic>Chemistry</topic><topic>Cross coupling</topic><topic>Crystallography</topic><topic>Ligands</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Palladium</topic><topic>Phosphines</topic><topic>Room temperature</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamola, Jairus L</creatorcontrib><creatorcontrib>Moshapo, Paseka T</creatorcontrib><creatorcontrib>Holzapfel, Cedric W</creatorcontrib><creatorcontrib>Maumela, Munaka Christopher</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamola, Jairus L</au><au>Moshapo, Paseka T</au><au>Holzapfel, Cedric W</au><au>Maumela, Munaka Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki-Miyaura cross-coupling reactions</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2021-08-05</date><risdate>2021</risdate><volume>11</volume><issue>43</issue><spage>26883</spage><epage>26891</epage><pages>26883-26891</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki-Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature.
Efficient palladium catalyst systems consisting of bench-stable biaryl phosphacycles and Pd(OAc)
2
are described for Suzuki-Miyaura cross-coupling reactions of a diverse array of aryl halides and arylboronic acids.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35480011</pmid><doi>10.1039/d1ra04947j</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7633-3966</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Bromides Chemical reactions Chemistry Cross coupling Crystallography Ligands NMR Nuclear magnetic resonance Palladium Phosphines Room temperature Substrates |
| title | Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki-Miyaura cross-coupling reactions |
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