Imaging Algorithm-Based Real-Time Shear Wave Elastography Combined with Thyroglobulin Antibodies in Diagnosis of Thyroid Cancer
To analyze the effect of real-time shear wave elastography (SWE) optimized by mathematical algorithms combined with thyroglobulin antibodies (TGAb) on the clinical diagnosis of differentiated thyroid carcinoma (DTC), a hybrid displacement estimation algorithm based on weighted phase separation and t...
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| creator | Xie, Xinjing Yang, Jun Liang, Guoxin Li, Chunxiang Li, Zhongyuan |
| description | To analyze the effect of real-time shear wave elastography (SWE) optimized by mathematical algorithms combined with thyroglobulin antibodies (TGAb) on the clinical diagnosis of differentiated thyroid carcinoma (DTC), a hybrid displacement estimation algorithm based on weighted phase separation and two-dimensional cross correlation was proposed. 102 patients with DTC were divided into a test group (TGAb-positive) and a control group (TGAb-negative). Real-time SWE based on hybrid displacement estimation algorithm was performed. Receiver operating characteristic (ROC) curve was adopted to analyze the characteristics of real-time SWE and its combination with TGAb to detect the sensitivity, specificity, and area under the curve (AUC) of the malignant degree of thyroid cancer. The results showed that the preoperative thyroid-stimulating hormone (TSH), thyroglobulin autoantibodies (TGAb), and thyroid peroxidase antibody (TPOAb) of TGAb-positive patients were higher than those of the TGAb-negative group (P |
| doi_str_mv | 10.1155/2021/7189334 |
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Real-time SWE based on hybrid displacement estimation algorithm was performed. Receiver operating characteristic (ROC) curve was adopted to analyze the characteristics of real-time SWE and its combination with TGAb to detect the sensitivity, specificity, and area under the curve (AUC) of the malignant degree of thyroid cancer. The results showed that the preoperative thyroid-stimulating hormone (TSH), thyroglobulin autoantibodies (TGAb), and thyroid peroxidase antibody (TPOAb) of TGAb-positive patients were higher than those of the TGAb-negative group (P<0.05). The preoperative tumors of TGAb-positive patients were multifocal, and the tumor size was larger than that of the TGAb-negative patients (P<0.05). The maximum Young’s modulus Emax of TGAb-positive patients was greater than that of TGAb-negative group (P<0.05). In addition, there was a very significant positive correlation between the patient’s TGAb level and Emax of Young’s modulus (P<0.001). The sensitivity, specificity, and AUC of the joint detection of real-time SWE Emax and TGAb for the malignant degree of thyroid cancer were significantly greater than those of the single real-time SWE and TGAb, and the difference was substantial (P<0.05). In short, joint detection of real-time SWE based on hybrid displacement estimation algorithm combined with TGAb had high sensitivity, specificity, and AUC for the diagnosis of DTC, which was suitable for clinical application.</description><identifier>ISSN: 1058-9244</identifier><identifier>EISSN: 1875-919X</identifier><identifier>DOI: 10.1155/2021/7189334</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Algorithms ; Antibodies ; Biomarkers ; Calcification ; Cancer ; Cross correlation ; Diagnosis ; Displacement ; Lymphatic system ; Modulus of elasticity ; Patients ; Peroxidase ; Phase separation ; Physicians ; Real time ; Sensitivity ; Serology ; Thyroid cancer ; Tumors ; Ultrasonic imaging</subject><ispartof>Scientific programming, 2021-07, Vol.2021, p.1-9</ispartof><rights>Copyright © 2021 Xinjing Xie et al.</rights><rights>Copyright © 2021 Xinjing Xie et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c294t-3540deb668164b2d72873568fe85a58f2a7440abfe2749d2a0eacb66aa3959763</cites><orcidid>0000-0002-6555-0519 ; 0000-0001-8674-2133 ; 0000-0003-0251-7073 ; 0000-0001-7157-304X ; 0000-0003-1815-2013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><contributor>Ramirez, Gustavo</contributor><contributor>Gustavo Ramirez</contributor><creatorcontrib>Xie, Xinjing</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Liang, Guoxin</creatorcontrib><creatorcontrib>Li, Chunxiang</creatorcontrib><creatorcontrib>Li, Zhongyuan</creatorcontrib><title>Imaging Algorithm-Based Real-Time Shear Wave Elastography Combined with Thyroglobulin Antibodies in Diagnosis of Thyroid Cancer</title><title>Scientific programming</title><description>To analyze the effect of real-time shear wave elastography (SWE) optimized by mathematical algorithms combined with thyroglobulin antibodies (TGAb) on the clinical diagnosis of differentiated thyroid carcinoma (DTC), a hybrid displacement estimation algorithm based on weighted phase separation and two-dimensional cross correlation was proposed. 102 patients with DTC were divided into a test group (TGAb-positive) and a control group (TGAb-negative). Real-time SWE based on hybrid displacement estimation algorithm was performed. Receiver operating characteristic (ROC) curve was adopted to analyze the characteristics of real-time SWE and its combination with TGAb to detect the sensitivity, specificity, and area under the curve (AUC) of the malignant degree of thyroid cancer. The results showed that the preoperative thyroid-stimulating hormone (TSH), thyroglobulin autoantibodies (TGAb), and thyroid peroxidase antibody (TPOAb) of TGAb-positive patients were higher than those of the TGAb-negative group (P<0.05). The preoperative tumors of TGAb-positive patients were multifocal, and the tumor size was larger than that of the TGAb-negative patients (P<0.05). The maximum Young’s modulus Emax of TGAb-positive patients was greater than that of TGAb-negative group (P<0.05). In addition, there was a very significant positive correlation between the patient’s TGAb level and Emax of Young’s modulus (P<0.001). The sensitivity, specificity, and AUC of the joint detection of real-time SWE Emax and TGAb for the malignant degree of thyroid cancer were significantly greater than those of the single real-time SWE and TGAb, and the difference was substantial (P<0.05). In short, joint detection of real-time SWE based on hybrid displacement estimation algorithm combined with TGAb had high sensitivity, specificity, and AUC for the diagnosis of DTC, which was suitable for clinical application.</description><subject>Algorithms</subject><subject>Antibodies</subject><subject>Biomarkers</subject><subject>Calcification</subject><subject>Cancer</subject><subject>Cross correlation</subject><subject>Diagnosis</subject><subject>Displacement</subject><subject>Lymphatic system</subject><subject>Modulus of elasticity</subject><subject>Patients</subject><subject>Peroxidase</subject><subject>Phase separation</subject><subject>Physicians</subject><subject>Real time</subject><subject>Sensitivity</subject><subject>Serology</subject><subject>Thyroid cancer</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>1058-9244</issn><issn>1875-919X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNp90FFLwzAQB_AiCs7pmx8g4KPWJWnSpo9zTh0MBJ3oW7m2aZvRJjPpHHvyq5vRPft0d_C7O_gHwTXB94RwPqGYkklCRBpF7CQYEZHwMCXp16nvMRdhShk7Dy6cW2NMBMF4FPwuOqiVrtG0rY1VfdOFD-Bkid4ktOFKdRK9NxIs-oQfieYtuN7UFjbNHs1Mlyvt6c6voVWzt6ZuTb5tlUZT3avclEo65KdHBbU2TjlkqgGqEs1AF9JeBmcVtE5eHes4-Hiar2Yv4fL1eTGbLsOCpqwPI85wKfM4FiRmOS0TKpKIx6KSggMXFYWEMQx5JWnC0pICllB4DhClPE3iaBzcDHc31nxvpeuztdla7V9mlHMfmGCYenU3qMIa56ysso1VHdh9RnB2iDg7RJwdI_b8duCN0iXs1P_6D1KAe8k</recordid><startdate>20210726</startdate><enddate>20210726</enddate><creator>Xie, Xinjing</creator><creator>Yang, Jun</creator><creator>Liang, Guoxin</creator><creator>Li, Chunxiang</creator><creator>Li, Zhongyuan</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SC</scope><scope>7SP</scope><scope>8FD</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><orcidid>https://orcid.org/0000-0002-6555-0519</orcidid><orcidid>https://orcid.org/0000-0001-8674-2133</orcidid><orcidid>https://orcid.org/0000-0003-0251-7073</orcidid><orcidid>https://orcid.org/0000-0001-7157-304X</orcidid><orcidid>https://orcid.org/0000-0003-1815-2013</orcidid></search><sort><creationdate>20210726</creationdate><title>Imaging Algorithm-Based Real-Time Shear Wave Elastography Combined with Thyroglobulin Antibodies in Diagnosis of Thyroid Cancer</title><author>Xie, Xinjing ; Yang, Jun ; Liang, Guoxin ; Li, Chunxiang ; Li, Zhongyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c294t-3540deb668164b2d72873568fe85a58f2a7440abfe2749d2a0eacb66aa3959763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Algorithms</topic><topic>Antibodies</topic><topic>Biomarkers</topic><topic>Calcification</topic><topic>Cancer</topic><topic>Cross correlation</topic><topic>Diagnosis</topic><topic>Displacement</topic><topic>Lymphatic system</topic><topic>Modulus of elasticity</topic><topic>Patients</topic><topic>Peroxidase</topic><topic>Phase separation</topic><topic>Physicians</topic><topic>Real time</topic><topic>Sensitivity</topic><topic>Serology</topic><topic>Thyroid cancer</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Xinjing</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Liang, Guoxin</creatorcontrib><creatorcontrib>Li, Chunxiang</creatorcontrib><creatorcontrib>Li, Zhongyuan</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Scientific programming</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Xinjing</au><au>Yang, Jun</au><au>Liang, Guoxin</au><au>Li, Chunxiang</au><au>Li, Zhongyuan</au><au>Ramirez, Gustavo</au><au>Gustavo Ramirez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging Algorithm-Based Real-Time Shear Wave Elastography Combined with Thyroglobulin Antibodies in Diagnosis of Thyroid Cancer</atitle><jtitle>Scientific programming</jtitle><date>2021-07-26</date><risdate>2021</risdate><volume>2021</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1058-9244</issn><eissn>1875-919X</eissn><abstract>To analyze the effect of real-time shear wave elastography (SWE) optimized by mathematical algorithms combined with thyroglobulin antibodies (TGAb) on the clinical diagnosis of differentiated thyroid carcinoma (DTC), a hybrid displacement estimation algorithm based on weighted phase separation and two-dimensional cross correlation was proposed. 102 patients with DTC were divided into a test group (TGAb-positive) and a control group (TGAb-negative). Real-time SWE based on hybrid displacement estimation algorithm was performed. Receiver operating characteristic (ROC) curve was adopted to analyze the characteristics of real-time SWE and its combination with TGAb to detect the sensitivity, specificity, and area under the curve (AUC) of the malignant degree of thyroid cancer. The results showed that the preoperative thyroid-stimulating hormone (TSH), thyroglobulin autoantibodies (TGAb), and thyroid peroxidase antibody (TPOAb) of TGAb-positive patients were higher than those of the TGAb-negative group (P<0.05). The preoperative tumors of TGAb-positive patients were multifocal, and the tumor size was larger than that of the TGAb-negative patients (P<0.05). The maximum Young’s modulus Emax of TGAb-positive patients was greater than that of TGAb-negative group (P<0.05). In addition, there was a very significant positive correlation between the patient’s TGAb level and Emax of Young’s modulus (P<0.001). The sensitivity, specificity, and AUC of the joint detection of real-time SWE Emax and TGAb for the malignant degree of thyroid cancer were significantly greater than those of the single real-time SWE and TGAb, and the difference was substantial (P<0.05). In short, joint detection of real-time SWE based on hybrid displacement estimation algorithm combined with TGAb had high sensitivity, specificity, and AUC for the diagnosis of DTC, which was suitable for clinical application.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2021/7189334</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6555-0519</orcidid><orcidid>https://orcid.org/0000-0001-8674-2133</orcidid><orcidid>https://orcid.org/0000-0003-0251-7073</orcidid><orcidid>https://orcid.org/0000-0001-7157-304X</orcidid><orcidid>https://orcid.org/0000-0003-1815-2013</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Algorithms Antibodies Biomarkers Calcification Cancer Cross correlation Diagnosis Displacement Lymphatic system Modulus of elasticity Patients Peroxidase Phase separation Physicians Real time Sensitivity Serology Thyroid cancer Tumors Ultrasonic imaging |
| title | Imaging Algorithm-Based Real-Time Shear Wave Elastography Combined with Thyroglobulin Antibodies in Diagnosis of Thyroid Cancer |
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