GI highlights from the literature
Sci Trans Med 2021; 13(597): eaba8146. doi: 10.1126/scitranslmed.aba8146 The antioxidant N-acetylcysteine (NAC) has well-established efficacy in treating paracetamol-related acute liver injury/liver failure if administered shortly after paracetamol exposure. Using a mouse model of paracetamol-induce...
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| Veröffentlicht in: | Gut 2021-09, Vol.70 (9), p.1795-1796 |
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| description | Sci Trans Med 2021; 13(597): eaba8146. doi: 10.1126/scitranslmed.aba8146 The antioxidant N-acetylcysteine (NAC) has well-established efficacy in treating paracetamol-related acute liver injury/liver failure if administered shortly after paracetamol exposure. Using a mouse model of paracetamol-induced liver injury, researchers demonstrated that the significantly raised levels of serum interleukin-11 (IL11) accompanying the condition are hepatocyte-derived, with IL11 causing dose-dependent hepatocyte cell death. Using both cell line and mouse experiments, researchers demonstrated that IL11 causes hepatotoxicity via nicotinamide adenine dinucleotide phosphate oxidase 4-mediated production of reactive oxygen species. From this cohort, 117 patients (56 patients with IBS, 25 patients with UC and 36 control patients) undergoing colorectal cancer screening (with normal findings at colonoscopy) were selected for in-depth microscopic analysis by 16S ribosomal RNA gene amplicon sequencing using biopsies from areas at least 10 cm from the biofilm in ‘biofilm-positive’ patients and biopsies from equivalent areas in ‘biofilm-negative’ patients. |
| doi_str_mv | 10.1136/gutjnl-2021-325649 |
| format | Article |
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Using a mouse model of paracetamol-induced liver injury, researchers demonstrated that the significantly raised levels of serum interleukin-11 (IL11) accompanying the condition are hepatocyte-derived, with IL11 causing dose-dependent hepatocyte cell death. Using both cell line and mouse experiments, researchers demonstrated that IL11 causes hepatotoxicity via nicotinamide adenine dinucleotide phosphate oxidase 4-mediated production of reactive oxygen species. From this cohort, 117 patients (56 patients with IBS, 25 patients with UC and 36 control patients) undergoing colorectal cancer screening (with normal findings at colonoscopy) were selected for in-depth microscopic analysis by 16S ribosomal RNA gene amplicon sequencing using biopsies from areas at least 10 cm from the biofilm in ‘biofilm-positive’ patients and biopsies from equivalent areas in ‘biofilm-negative’ patients.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2021-325649</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Acetylcysteine ; Analgesics ; Antioxidants ; Asymptomatic ; Biofilms ; Biopsy ; Cancer screening ; Cell death ; Chlamydia ; Colorectal carcinoma ; Cytokines ; Dendritic cells ; Endoscopy ; Gastroenterology ; Hepatotoxicity ; Infections ; Inflammation ; Inflammatory bowel disease ; Interleukin 1 ; Interleukin 11 ; Irritable bowel syndrome ; Liver ; Liver diseases ; Medical screening ; NAD(P)H oxidase ; NADPH-diaphorase ; Paracetamol ; Pathogenesis ; Patients ; Reactive oxygen species ; Remission (Medicine) ; rRNA 16S</subject><ispartof>Gut, 2021-09, Vol.70 (9), p.1795-1796</ispartof><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1568-3978</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Smith, Philip J</creatorcontrib><title>GI highlights from the literature</title><title>Gut</title><description>Sci Trans Med 2021; 13(597): eaba8146. doi: 10.1126/scitranslmed.aba8146 The antioxidant N-acetylcysteine (NAC) has well-established efficacy in treating paracetamol-related acute liver injury/liver failure if administered shortly after paracetamol exposure. Using a mouse model of paracetamol-induced liver injury, researchers demonstrated that the significantly raised levels of serum interleukin-11 (IL11) accompanying the condition are hepatocyte-derived, with IL11 causing dose-dependent hepatocyte cell death. Using both cell line and mouse experiments, researchers demonstrated that IL11 causes hepatotoxicity via nicotinamide adenine dinucleotide phosphate oxidase 4-mediated production of reactive oxygen species. From this cohort, 117 patients (56 patients with IBS, 25 patients with UC and 36 control patients) undergoing colorectal cancer screening (with normal findings at colonoscopy) were selected for in-depth microscopic analysis by 16S ribosomal RNA gene amplicon sequencing using biopsies from areas at least 10 cm from the biofilm in ‘biofilm-positive’ patients and biopsies from equivalent areas in ‘biofilm-negative’ patients.</description><subject>Acetylcysteine</subject><subject>Analgesics</subject><subject>Antioxidants</subject><subject>Asymptomatic</subject><subject>Biofilms</subject><subject>Biopsy</subject><subject>Cancer screening</subject><subject>Cell death</subject><subject>Chlamydia</subject><subject>Colorectal carcinoma</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Endoscopy</subject><subject>Gastroenterology</subject><subject>Hepatotoxicity</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Interleukin 1</subject><subject>Interleukin 11</subject><subject>Irritable bowel syndrome</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medical screening</subject><subject>NAD(P)H oxidase</subject><subject>NADPH-diaphorase</subject><subject>Paracetamol</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Reactive oxygen species</subject><subject>Remission (Medicine)</subject><subject>rRNA 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1453-ae0a0219e870266cf02db9b8879fbecba59aaf0a67e1877f95c7b75ec77091ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylcysteine</topic><topic>Analgesics</topic><topic>Antioxidants</topic><topic>Asymptomatic</topic><topic>Biofilms</topic><topic>Biopsy</topic><topic>Cancer screening</topic><topic>Cell death</topic><topic>Chlamydia</topic><topic>Colorectal carcinoma</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Endoscopy</topic><topic>Gastroenterology</topic><topic>Hepatotoxicity</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Interleukin 1</topic><topic>Interleukin 11</topic><topic>Irritable bowel syndrome</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Medical screening</topic><topic>NAD(P)H oxidase</topic><topic>NADPH-diaphorase</topic><topic>Paracetamol</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Reactive oxygen species</topic><topic>Remission (Medicine)</topic><topic>rRNA 16S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Philip J</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 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Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Philip J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GI highlights from the literature</atitle><jtitle>Gut</jtitle><date>2021-09</date><risdate>2021</risdate><volume>70</volume><issue>9</issue><spage>1795</spage><epage>1796</epage><pages>1795-1796</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><abstract>Sci Trans Med 2021; 13(597): eaba8146. doi: 10.1126/scitranslmed.aba8146 The antioxidant N-acetylcysteine (NAC) has well-established efficacy in treating paracetamol-related acute liver injury/liver failure if administered shortly after paracetamol exposure. Using a mouse model of paracetamol-induced liver injury, researchers demonstrated that the significantly raised levels of serum interleukin-11 (IL11) accompanying the condition are hepatocyte-derived, with IL11 causing dose-dependent hepatocyte cell death. Using both cell line and mouse experiments, researchers demonstrated that IL11 causes hepatotoxicity via nicotinamide adenine dinucleotide phosphate oxidase 4-mediated production of reactive oxygen species. From this cohort, 117 patients (56 patients with IBS, 25 patients with UC and 36 control patients) undergoing colorectal cancer screening (with normal findings at colonoscopy) were selected for in-depth microscopic analysis by 16S ribosomal RNA gene amplicon sequencing using biopsies from areas at least 10 cm from the biofilm in ‘biofilm-positive’ patients and biopsies from equivalent areas in ‘biofilm-negative’ patients.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/gutjnl-2021-325649</doi><tpages>2</tpages><orcidid>https://orcid.org/0000-0003-1568-3978</orcidid></addata></record> |
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| language | eng |
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| source | PubMed Central |
| subjects | Acetylcysteine Analgesics Antioxidants Asymptomatic Biofilms Biopsy Cancer screening Cell death Chlamydia Colorectal carcinoma Cytokines Dendritic cells Endoscopy Gastroenterology Hepatotoxicity Infections Inflammation Inflammatory bowel disease Interleukin 1 Interleukin 11 Irritable bowel syndrome Liver Liver diseases Medical screening NAD(P)H oxidase NADPH-diaphorase Paracetamol Pathogenesis Patients Reactive oxygen species Remission (Medicine) rRNA 16S |
| title | GI highlights from the literature |
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