Improving Catalytic Activity and Reversing Enantio‐Specificity of ω‐Transaminase by Semi‐Rational Engineering en Route to Chiral Bulky β‐Amino Esters

The application of wild‐type ω‐transaminase was limited by steric hindrance towards bulky substrates, therefore improvement of the catalytic efficiency and stereoselectivity toward substrates with two bulky substituent adjacent to the carbonyl is of general interest. In this study, according to the...

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Veröffentlicht in:	ChemCatChem 2021-08, Vol.13 (15), p.3396-3400
Hauptverfasser:	Wang, Yingang, Feng, Jinhui, Dong, Wenyue, Chen, Xi, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Amino acids Asymmetric synthesis Carbonyls Catalytic activity Enantiomers Esters semi-rational enzyme design Stereoselectivity Steric hindrance Substrates Transaminases β-keto esters ω-Transaminase
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