The effect of genetic polymorphisms on treatment duration following premolar extraction
To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of cl...
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| Veröffentlicht in: | Scientific reports 2021-08, Vol.11 (1), p.15942-15942, Article 15942 |
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| description | To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of
WNT3A
,
SPP1
(rs4754, rs9138), and
TNFSF11
, TT genotype of
SPP1
(rs1126616), and GG genotype of
SFRP2
was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of
SPP1
, AA genotype of
P2RX7
, CT genotype of
TNFSF11
, and AG genotype of
TNFRSF11A
tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists. |
| doi_str_mv | 10.1038/s41598-021-94979-8 |
| format | Article |
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WNT3A
,
SPP1
(rs4754, rs9138), and
TNFSF11
, TT genotype of
SPP1
(rs1126616), and GG genotype of
SFRP2
was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of
SPP1
, AA genotype of
P2RX7
, CT genotype of
TNFSF11
, and AG genotype of
TNFRSF11A
tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-94979-8</identifier><identifier>PMID: 34354108</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208 ; 692/308 ; Adolescent ; Adult ; Bicuspid - surgery ; Case-Control Studies ; DNA sequencing ; Duration of Therapy ; Female ; Gene Expression ; Gene Frequency ; Gene polymorphism ; Genetic factors ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Genotypes ; Haplotypes ; Humanities and Social Sciences ; Humans ; Male ; Membrane Proteins - genetics ; Middle Aged ; multidisciplinary ; Multidisciplinary Sciences ; Next-generation sequencing ; Orthodontics ; Orthodontics - methods ; Osteopontin - genetics ; Osteoprotegerin ; Patients ; Polymorphism, Single Nucleotide ; RANK Ligand - genetics ; Receptors, Purinergic P2X7 - genetics ; Retrospective Studies ; Saliva ; Science ; Science & Technology ; Science & Technology - Other Topics ; Science (multidisciplinary) ; Single-nucleotide polymorphism ; Transcriptome ; Treatment Outcome ; Wnt3A Protein - genetics</subject><ispartof>Scientific reports, 2021-08, Vol.11 (1), p.15942-15942, Article 15942</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000684439300001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c540t-8dcfbfa428c5d03dd1a012ae86cd2e5fd41c0368e3e9a4625e41f5101c93f4dd3</citedby><cites>FETCH-LOGICAL-c540t-8dcfbfa428c5d03dd1a012ae86cd2e5fd41c0368e3e9a4625e41f5101c93f4dd3</cites><orcidid>0000-0002-1150-0268 ; 0000-0003-2795-531X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342496/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342496/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,41125,42194,51581,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34354108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Jiyon</creatorcontrib><creatorcontrib>Choi, Yoon Jeong</creatorcontrib><creatorcontrib>Choi, Sung-Hwan</creatorcontrib><creatorcontrib>Jung, Han-Sung</creatorcontrib><creatorcontrib>Lee, Ji Hyun</creatorcontrib><creatorcontrib>Cha, Jung-Yul</creatorcontrib><title>The effect of genetic polymorphisms on treatment duration following premolar extraction</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>SCI REP-UK</addtitle><addtitle>Sci Rep</addtitle><description>To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of
WNT3A
,
SPP1
(rs4754, rs9138), and
TNFSF11
, TT genotype of
SPP1
(rs1126616), and GG genotype of
SFRP2
was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of
SPP1
, AA genotype of
P2RX7
, CT genotype of
TNFSF11
, and AG genotype of
TNFRSF11A
tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.</description><subject>631/208</subject><subject>692/308</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Bicuspid - surgery</subject><subject>Case-Control Studies</subject><subject>DNA sequencing</subject><subject>Duration of Therapy</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic factors</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multidisciplinary Sciences</subject><subject>Next-generation sequencing</subject><subject>Orthodontics</subject><subject>Orthodontics - methods</subject><subject>Osteopontin - genetics</subject><subject>Osteoprotegerin</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide</subject><subject>RANK Ligand - genetics</subject><subject>Receptors, Purinergic P2X7 - genetics</subject><subject>Retrospective Studies</subject><subject>Saliva</subject><subject>Science</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Science (multidisciplinary)</subject><subject>Single-nucleotide polymorphism</subject><subject>Transcriptome</subject><subject>Treatment Outcome</subject><subject>Wnt3A Protein - genetics</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk2LFDEQhhtR3GXcP-BBGrwI0prPnuQiyODHwoKXFY8hk1R6MnR3xiTtuv_e9PQ67noQc0moeuqlKvVW1XOM3mBExdvEMJeiQQQ3ksm1bMSj6pwgxhtCCXl8731WXaS0R-VwIhmWT6szyihnGInz6tv1DmpwDkyug6s7GCF7Ux9CfzuEeNj5NKQ6jHWOoPMAY67tFHX2JeRC34cbP3b1IcIQeh1r-JmjNnP2WfXE6T7Bxd29qr5-_HC9-dxcffl0uXl_1RjOUG6ENW7rNCPCcIuotVgjTDSI1lgC3FmGDaKtAApSs5ZwYNhxjLCR1DFr6aq6XHRt0Ht1iH7Q8VYF7dUxEGKndCwT9aBaIgkDB0WLs61xWhoQrhVUC0HAsKL1btE6TNsBrCnTRt0_EH2YGf1OdeGHEpQRJtsi8OpOIIbvE6SsBp8M9L0eIUxJEc4lo2gtZvTlX-g-THEsXzVTgrQtx-tCkYUyMaQUwZ2awUjNNlCLDVSxgTraoPSyql7cH-NU8nvpBRALcAPb4JLxMBo4YcUnrWCMSjpbBm98Pq57E6Yxl9LX_19aaLrQqRBjB_HPkP_o_xfTaODY</recordid><startdate>20210805</startdate><enddate>20210805</enddate><creator>Yu, Jiyon</creator><creator>Choi, Yoon Jeong</creator><creator>Choi, Sung-Hwan</creator><creator>Jung, Han-Sung</creator><creator>Lee, Ji Hyun</creator><creator>Cha, Jung-Yul</creator><general>Nature Publishing Group UK</general><general>NATURE PORTFOLIO</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1150-0268</orcidid><orcidid>https://orcid.org/0000-0003-2795-531X</orcidid></search><sort><creationdate>20210805</creationdate><title>The effect of genetic polymorphisms on treatment duration following premolar extraction</title><author>Yu, Jiyon ; Choi, Yoon Jeong ; Choi, Sung-Hwan ; Jung, Han-Sung ; Lee, Ji Hyun ; Cha, Jung-Yul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-8dcfbfa428c5d03dd1a012ae86cd2e5fd41c0368e3e9a4625e41f5101c93f4dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/208</topic><topic>692/308</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Bicuspid - surgery</topic><topic>Case-Control Studies</topic><topic>DNA sequencing</topic><topic>Duration of Therapy</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic factors</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Haplotypes</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Multidisciplinary Sciences</topic><topic>Next-generation sequencing</topic><topic>Orthodontics</topic><topic>Orthodontics - methods</topic><topic>Osteopontin - genetics</topic><topic>Osteoprotegerin</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide</topic><topic>RANK Ligand - genetics</topic><topic>Receptors, Purinergic P2X7 - genetics</topic><topic>Retrospective Studies</topic><topic>Saliva</topic><topic>Science</topic><topic>Science & Technology</topic><topic>Science & Technology - Other Topics</topic><topic>Science (multidisciplinary)</topic><topic>Single-nucleotide polymorphism</topic><topic>Transcriptome</topic><topic>Treatment Outcome</topic><topic>Wnt3A Protein - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Jiyon</creatorcontrib><creatorcontrib>Choi, Yoon Jeong</creatorcontrib><creatorcontrib>Choi, Sung-Hwan</creatorcontrib><creatorcontrib>Jung, Han-Sung</creatorcontrib><creatorcontrib>Lee, Ji Hyun</creatorcontrib><creatorcontrib>Cha, Jung-Yul</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Jiyon</au><au>Choi, Yoon Jeong</au><au>Choi, Sung-Hwan</au><au>Jung, Han-Sung</au><au>Lee, Ji Hyun</au><au>Cha, Jung-Yul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of genetic polymorphisms on treatment duration following premolar extraction</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2021-08-05</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>15942</spage><epage>15942</epage><pages>15942-15942</pages><artnum>15942</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of
WNT3A
,
SPP1
(rs4754, rs9138), and
TNFSF11
, TT genotype of
SPP1
(rs1126616), and GG genotype of
SFRP2
was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of
SPP1
, AA genotype of
P2RX7
, CT genotype of
TNFSF11
, and AG genotype of
TNFRSF11A
tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34354108</pmid><doi>10.1038/s41598-021-94979-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1150-0268</orcidid><orcidid>https://orcid.org/0000-0003-2795-531X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/208 692/308 Adolescent Adult Bicuspid - surgery Case-Control Studies DNA sequencing Duration of Therapy Female Gene Expression Gene Frequency Gene polymorphism Genetic factors Genetic Predisposition to Disease Genotype Genotype & phenotype Genotypes Haplotypes Humanities and Social Sciences Humans Male Membrane Proteins - genetics Middle Aged multidisciplinary Multidisciplinary Sciences Next-generation sequencing Orthodontics Orthodontics - methods Osteopontin - genetics Osteoprotegerin Patients Polymorphism, Single Nucleotide RANK Ligand - genetics Receptors, Purinergic P2X7 - genetics Retrospective Studies Saliva Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Single-nucleotide polymorphism Transcriptome Treatment Outcome Wnt3A Protein - genetics |
| title | The effect of genetic polymorphisms on treatment duration following premolar extraction |
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