On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination
Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. Thi...
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| Veröffentlicht in: | Applied physics letters 2021-08, Vol.119 (5) |
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| container_title | Applied physics letters |
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| creator | Szili, Endre J. Ghimire, Bhagirath Patenall, Bethany Lee Rohaim, Mohammed Mistry, Dharmit Fellows, Adrian Munir, Muhammad Jenkins, A. Toby A. Short, Robert D. |
| description | Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the “on-demand” activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2). |
| doi_str_mv | 10.1063/5.0062787 |
| format | Article |
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The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2).</description><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Applied physics</subject><subject>Bacteria</subject><subject>Cold plasmas</subject><subject>Decontamination</subject><subject>Hydrogen peroxide</subject><subject>Infectious diseases</subject><subject>Oxidation</subject><subject>Peracetic acid</subject><subject>Pseudomonas aeruginosa</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Viruses</subject><issn>0003-6951</issn><issn>1077-3118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqdkE1LAzEQhoMoWKsH_0HAk8LWZKfZ7B6l-AWFXhS8hWw-IGV3sybpQv-9sS149zAMMzzvDO-L0C0lC0oqeGQLQqqS1_wMzSjhvABK63M0I4RAUTWMXqKrGLd5ZCXADH1thkKbXg4aK99pPHYy9hJLldwkk_MD9jZPJu07rP3gQ8TWB9xmwASXwSycXNhFrI3yQ5K9Gw66a3RhZRfNzanP0efL88fqrVhvXt9XT-tCQVWmgivCJTNcSqhqsuTcap13SlNleUvqikL2RRvWKDAtkIZqa6WyZtmAbRWFObo73h2D_96ZmMTW78KQX4qSsbpcAs81R_dHSgUfYzBWjMH1MuwFJeI3OMHEKbjMPhzZqFw6ePkfPPnwB4pRW_gBSll8pA</recordid><startdate>20210802</startdate><enddate>20210802</enddate><creator>Szili, Endre J.</creator><creator>Ghimire, Bhagirath</creator><creator>Patenall, Bethany Lee</creator><creator>Rohaim, Mohammed</creator><creator>Mistry, Dharmit</creator><creator>Fellows, Adrian</creator><creator>Munir, Muhammad</creator><creator>Jenkins, A. Toby A.</creator><creator>Short, Robert D.</creator><general>American Institute of Physics</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-5165-1490</orcidid><orcidid>https://orcid.org/0000-0002-5243-8528</orcidid></search><sort><creationdate>20210802</creationdate><title>On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination</title><author>Szili, Endre J. ; Ghimire, Bhagirath ; Patenall, Bethany Lee ; Rohaim, Mohammed ; Mistry, Dharmit ; Fellows, Adrian ; Munir, Muhammad ; Jenkins, A. 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| language | eng |
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| source | AIP Journals Complete; Alma/SFX Local Collection |
| subjects | Antibiotics Antimicrobial agents Applied physics Bacteria Cold plasmas Decontamination Hydrogen peroxide Infectious diseases Oxidation Peracetic acid Pseudomonas aeruginosa Severe acute respiratory syndrome coronavirus 2 Viruses |
| title | On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination |
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