Discovery of 4H‐thienopyrrole derivatives as potential anticancer agents

In this study, we describe the discovery of the 4H‐thieno[3,2‐b]pyrrole derivatives as an useful scaffold to obtain potent lead compounds for the treatment of colon cancer. We first started with the 4H‐thieno[3,2‐b]pyrrole derivatives which come from compound libraries screening, and then optimized...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of heterocyclic chemistry 2021-08, Vol.58 (8), p.1610-1627
Hauptverfasser:	Fang, Bo, Hu, Chunsheng, Ding, Yong, Qin, Hongxia, Luo, Yafei, Xu, Zhigang, Meng, Jiangping, Chen, Zhongzhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Apoptosis Biological activity Cellular structure Colon Colorectal cancer Flow cytometry Lead compounds Methionine Molecular docking
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!