Pyridine‐derived VEGFR‐2 inhibitors: Rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking

Novel pyridine‐derived compounds (5–19) were designed and synthesized, and their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the VEGFR‐2 enzyme. Compounds 10, 9, 8, and 15 were found to be the most potent derivatives against the two cancer cell lines, HepG2 and MCF‐...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2021-08, Vol.354 (8), p.e2100085-n/a
Hauptverfasser:	Saleh, Nashwa M., Abdel‐Rahman, Adel A.‐H., Omar, Asmaa M., Khalifa, Mohamed M., El‐Adl, Khaled
Format:	Artikel
Sprache:	eng
Schlagworte:	2‐cyanoacetohydrazone Animals anticancer agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast cancer Cancer Chlorocebus aethiops Doxorubicin - pharmacology Drug Design Hep G2 Cells Humans Inhibitory Concentration 50 MCF-7 Cells molecular docking Molecular Docking Simulation pyridines Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Sorafenib - pharmacology Structure-Activity Relationship Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors VEGFR‐2 inhibitors Vero Cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!