MicroRNAs EXPRESSION PROFILES IN NON-SMALL CELL LUNG CANCER
MicroRNAs (miRNAs) are a new endogenous small non-coding RNA family that arranges expression of a few genes related in normal development as well as human diseases such as cancer. miRNAs are developing as potential diagnostic and therapeutic markers with deregulated expression in various cancers inc...
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| Veröffentlicht in: | Fresenius environmental bulletin 2021-07, Vol.30 (7A), p.9107 |
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| container_title | Fresenius environmental bulletin |
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| creator | Yaroglu, Hatice Yildirim Akbayir, Serin Gorur, Aysegul Balci, Senay Unal, Nil Ayaz, Lokman Ayan, Erhan Tamer, Lulufer |
| description | MicroRNAs (miRNAs) are a new endogenous small non-coding RNA family that arranges expression of a few genes related in normal development as well as human diseases such as cancer. miRNAs are developing as potential diagnostic and therapeutic markers with deregulated expression in various cancers including lung cancer. In this study, we aimed to find out miRNA expression profiles and to show the relationship between non-small cell lung cancer and microRNAs levels, if there is. In the present study, the expression profiles of 740 miRNA in plasma from 31 patients and 64 healthy subjects were evaluated using high-throughput real-time quantitative polymerase chain reaction. All statistical analyses were performed using the Bi-ogazelle's qbase PLUS 2.0 software. Our results showed that expression levels of 7 microRNAs (miR-20b-5p, -30c, -146a, -192-5p, -206, -484, -574-3p) were significantly upregulated in patients when compared to control group (p< 0.05). Expression levels of five miRNAs (miR-24-3p, -30a-5p, -106b-5p, -223-3p, -331-5p) were found significantly downregulated in lung cancer patients (p< 0.05). Conclusion: In conclusion, our result showed that up-regulated and down-regulated miRNAs may be important role of early detection in non-small cell lung cancer. |
| format | Article |
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In this study, we aimed to find out miRNA expression profiles and to show the relationship between non-small cell lung cancer and microRNAs levels, if there is. In the present study, the expression profiles of 740 miRNA in plasma from 31 patients and 64 healthy subjects were evaluated using high-throughput real-time quantitative polymerase chain reaction. All statistical analyses were performed using the Bi-ogazelle's qbase PLUS 2.0 software. Our results showed that expression levels of 7 microRNAs (miR-20b-5p, -30c, -146a, -192-5p, -206, -484, -574-3p) were significantly upregulated in patients when compared to control group (p< 0.05). Expression levels of five miRNAs (miR-24-3p, -30a-5p, -106b-5p, -223-3p, -331-5p) were found significantly downregulated in lung cancer patients (p< 0.05). Conclusion: In conclusion, our result showed that up-regulated and down-regulated miRNAs may be important role of early detection in non-small cell lung cancer.</description><identifier>ISSN: 1018-4619</identifier><identifier>EISSN: 1610-2304</identifier><language>eng</language><publisher>Freising: Parlar Scientific Publications</publisher><subject>Deregulation ; Gene expression ; Lung cancer ; MicroRNAs ; miRNA ; Non-coding RNA ; Non-small cell lung carcinoma ; Polymerase chain reaction ; Small cell lung carcinoma ; Statistical analysis</subject><ispartof>Fresenius environmental bulletin, 2021-07, Vol.30 (7A), p.9107</ispartof><rights>Copyright Parlar Scientific Publications Jul 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Yaroglu, Hatice Yildirim</creatorcontrib><creatorcontrib>Akbayir, Serin</creatorcontrib><creatorcontrib>Gorur, Aysegul</creatorcontrib><creatorcontrib>Balci, Senay</creatorcontrib><creatorcontrib>Unal, Nil</creatorcontrib><creatorcontrib>Ayaz, Lokman</creatorcontrib><creatorcontrib>Ayan, Erhan</creatorcontrib><creatorcontrib>Tamer, Lulufer</creatorcontrib><title>MicroRNAs EXPRESSION PROFILES IN NON-SMALL CELL LUNG CANCER</title><title>Fresenius environmental bulletin</title><description>MicroRNAs (miRNAs) are a new endogenous small non-coding RNA family that arranges expression of a few genes related in normal development as well as human diseases such as cancer. miRNAs are developing as potential diagnostic and therapeutic markers with deregulated expression in various cancers including lung cancer. In this study, we aimed to find out miRNA expression profiles and to show the relationship between non-small cell lung cancer and microRNAs levels, if there is. In the present study, the expression profiles of 740 miRNA in plasma from 31 patients and 64 healthy subjects were evaluated using high-throughput real-time quantitative polymerase chain reaction. All statistical analyses were performed using the Bi-ogazelle's qbase PLUS 2.0 software. Our results showed that expression levels of 7 microRNAs (miR-20b-5p, -30c, -146a, -192-5p, -206, -484, -574-3p) were significantly upregulated in patients when compared to control group (p< 0.05). Expression levels of five miRNAs (miR-24-3p, -30a-5p, -106b-5p, -223-3p, -331-5p) were found significantly downregulated in lung cancer patients (p< 0.05). Conclusion: In conclusion, our result showed that up-regulated and down-regulated miRNAs may be important role of early detection in non-small cell lung cancer.</description><subject>Deregulation</subject><subject>Gene expression</subject><subject>Lung cancer</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Non-coding RNA</subject><subject>Non-small cell lung carcinoma</subject><subject>Polymerase chain reaction</subject><subject>Small cell lung carcinoma</subject><subject>Statistical analysis</subject><issn>1018-4619</issn><issn>1610-2304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNotjV1rwjAYhcPYYKL-h8CuA28-mg-8KiG6QkylneCd2DaFyVhdo_9_ge1wOM-5OucJLaikQBgH8Zw7UE2EpOYVrVO6QpZkikm-QJv9Zz9PTSgTdqdD49q2qgM-NPW28q7FVcChDqTdl95j63L4Y9hhWwbrmhV6GS9fKa7_uUTHrfuw78TXu8qWntwo5XfCTATFNEjoRXah-wEuWkvGOkVHGE1nBjA80kJoqWjknCszgooSukGJgS_R29_ubZ5-HjHdz9fpMX_nyzMrCqWlporxX-6VPmo</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Yaroglu, Hatice Yildirim</creator><creator>Akbayir, Serin</creator><creator>Gorur, Aysegul</creator><creator>Balci, Senay</creator><creator>Unal, Nil</creator><creator>Ayaz, Lokman</creator><creator>Ayan, Erhan</creator><creator>Tamer, Lulufer</creator><general>Parlar Scientific Publications</general><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>20210701</creationdate><title>MicroRNAs EXPRESSION PROFILES IN NON-SMALL CELL LUNG CANCER</title><author>Yaroglu, Hatice Yildirim ; Akbayir, Serin ; Gorur, Aysegul ; Balci, Senay ; Unal, Nil ; Ayaz, Lokman ; Ayan, Erhan ; Tamer, Lulufer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p113t-29e0728060c40c458cd0a88622b71f0f9b9d093e1548671e33379f07e60bd74d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Deregulation</topic><topic>Gene expression</topic><topic>Lung cancer</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Non-coding RNA</topic><topic>Non-small cell lung carcinoma</topic><topic>Polymerase chain reaction</topic><topic>Small cell lung carcinoma</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaroglu, Hatice Yildirim</creatorcontrib><creatorcontrib>Akbayir, Serin</creatorcontrib><creatorcontrib>Gorur, Aysegul</creatorcontrib><creatorcontrib>Balci, Senay</creatorcontrib><creatorcontrib>Unal, Nil</creatorcontrib><creatorcontrib>Ayaz, Lokman</creatorcontrib><creatorcontrib>Ayan, Erhan</creatorcontrib><creatorcontrib>Tamer, Lulufer</creatorcontrib><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Fresenius environmental bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaroglu, Hatice Yildirim</au><au>Akbayir, Serin</au><au>Gorur, Aysegul</au><au>Balci, Senay</au><au>Unal, Nil</au><au>Ayaz, Lokman</au><au>Ayan, Erhan</au><au>Tamer, Lulufer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNAs EXPRESSION PROFILES IN NON-SMALL CELL LUNG CANCER</atitle><jtitle>Fresenius environmental bulletin</jtitle><date>2021-07-01</date><risdate>2021</risdate><volume>30</volume><issue>7A</issue><spage>9107</spage><pages>9107-</pages><issn>1018-4619</issn><eissn>1610-2304</eissn><abstract>MicroRNAs (miRNAs) are a new endogenous small non-coding RNA family that arranges expression of a few genes related in normal development as well as human diseases such as cancer. miRNAs are developing as potential diagnostic and therapeutic markers with deregulated expression in various cancers including lung cancer. In this study, we aimed to find out miRNA expression profiles and to show the relationship between non-small cell lung cancer and microRNAs levels, if there is. In the present study, the expression profiles of 740 miRNA in plasma from 31 patients and 64 healthy subjects were evaluated using high-throughput real-time quantitative polymerase chain reaction. All statistical analyses were performed using the Bi-ogazelle's qbase PLUS 2.0 software. Our results showed that expression levels of 7 microRNAs (miR-20b-5p, -30c, -146a, -192-5p, -206, -484, -574-3p) were significantly upregulated in patients when compared to control group (p< 0.05). Expression levels of five miRNAs (miR-24-3p, -30a-5p, -106b-5p, -223-3p, -331-5p) were found significantly downregulated in lung cancer patients (p< 0.05). 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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Deregulation Gene expression Lung cancer MicroRNAs miRNA Non-coding RNA Non-small cell lung carcinoma Polymerase chain reaction Small cell lung carcinoma Statistical analysis |
| title | MicroRNAs EXPRESSION PROFILES IN NON-SMALL CELL LUNG CANCER |
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