A neural circuit for excessive feeding driven by environmental context in mice

Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how...

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Veröffentlicht in:Nature neuroscience 2021-08, Vol.24 (8), p.1132-1141
Hauptverfasser: Mohammad, Hasan, Senol, Esra, Graf, Martin, Lee, Chun-Yao, Li, Qin, Liu, Qing, Yeo, Xin Yi, Wang, Menghan, Laskaratos, Achilleas, Xu, Fuqiang, Luo, Sarah Xinwei, Jung, Sangyong, Augustine, George J., Fu, Yu
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container_issue 8
container_start_page 1132
container_title Nature neuroscience
container_volume 24
creator Mohammad, Hasan
Senol, Esra
Graf, Martin
Lee, Chun-Yao
Li, Qin
Liu, Qing
Yeo, Xin Yi
Wang, Menghan
Laskaratos, Achilleas
Xu, Fuqiang
Luo, Sarah Xinwei
Jung, Sangyong
Augustine, George J.
Fu, Yu
description Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how environmental context drives non-homeostatic feeding is elusive. Here, we identify a population of somatostatin ( TN SST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of TN SST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and TN SST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting TN SST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding. Tuberal nucleus SST + neurons respond to palatable food. The activity of these SST neurons together with their plastic inputs from the ventral subiculum play critical roles in contextually conditioned feeding.
doi_str_mv 10.1038/s41593-021-00875-9
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subjects 631/378/1488/1562
631/378/3920
Animal Genetics and Genomics
Animals
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain research
Circuits
Cognitive ability
Context
Cues
Environmental factors
Feeding
Feeding Behavior - physiology
Food
Food habits
Hippocampus
Hypothalamus
Hypothalamus - physiology
Life Sciences & Biomedicine
Male
Mice
Neural circuitry
Neural Pathways - physiology
Neurobiology
Neurons
Neurons - physiology
Neurosciences
Neurosciences & Neurology
Obesity
Physiological aspects
Physiological effects
Physiology
Psychological aspects
Science & Technology
Somatostatin
Somatostatin - metabolism
Subiculum
Synaptic transmission
title A neural circuit for excessive feeding driven by environmental context in mice
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