A neural circuit for excessive feeding driven by environmental context in mice
Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how...
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| Veröffentlicht in: | Nature neuroscience 2021-08, Vol.24 (8), p.1132-1141 |
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| creator | Mohammad, Hasan Senol, Esra Graf, Martin Lee, Chun-Yao Li, Qin Liu, Qing Yeo, Xin Yi Wang, Menghan Laskaratos, Achilleas Xu, Fuqiang Luo, Sarah Xinwei Jung, Sangyong Augustine, George J. Fu, Yu |
| description | Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how environmental context drives non-homeostatic feeding is elusive. Here, we identify a population of somatostatin (
TN
SST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of
TN
SST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and
TN
SST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting
TN
SST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding.
Tuberal nucleus SST
+
neurons respond to palatable food. The activity of these SST neurons together with their plastic inputs from the ventral subiculum play critical roles in contextually conditioned feeding. |
| doi_str_mv | 10.1038/s41593-021-00875-9 |
| format | Article |
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TN
SST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of
TN
SST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and
TN
SST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting
TN
SST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding.
Tuberal nucleus SST
+
neurons respond to palatable food. The activity of these SST neurons together with their plastic inputs from the ventral subiculum play critical roles in contextually conditioned feeding.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/s41593-021-00875-9</identifier><identifier>PMID: 34168339</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/378/1488/1562 ; 631/378/3920 ; Animal Genetics and Genomics ; Animals ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Brain research ; Circuits ; Cognitive ability ; Context ; Cues ; Environmental factors ; Feeding ; Feeding Behavior - physiology ; Food ; Food habits ; Hippocampus ; Hypothalamus ; Hypothalamus - physiology ; Life Sciences & Biomedicine ; Male ; Mice ; Neural circuitry ; Neural Pathways - physiology ; Neurobiology ; Neurons ; Neurons - physiology ; Neurosciences ; Neurosciences & Neurology ; Obesity ; Physiological aspects ; Physiological effects ; Physiology ; Psychological aspects ; Science & Technology ; Somatostatin ; Somatostatin - metabolism ; Subiculum ; Synaptic transmission</subject><ispartof>Nature neuroscience, 2021-08, Vol.24 (8), p.1132-1141</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>17</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000665692400002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c476t-43729cd19ecddd1c1590c7a32963897a6ec3d39f4564e1cecd24bca6c2a34913</citedby><cites>FETCH-LOGICAL-c476t-43729cd19ecddd1c1590c7a32963897a6ec3d39f4564e1cecd24bca6c2a34913</cites><orcidid>0000-0003-1546-4564 ; 0000-0001-7408-7485 ; 0000-0003-4878-0520 ; 0000-0002-5309-4034 ; 0000-0002-2456-5781 ; 0000-0002-9226-1982 ; 0000-0001-9859-1184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932,39265</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34168339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohammad, Hasan</creatorcontrib><creatorcontrib>Senol, Esra</creatorcontrib><creatorcontrib>Graf, Martin</creatorcontrib><creatorcontrib>Lee, Chun-Yao</creatorcontrib><creatorcontrib>Li, Qin</creatorcontrib><creatorcontrib>Liu, Qing</creatorcontrib><creatorcontrib>Yeo, Xin Yi</creatorcontrib><creatorcontrib>Wang, Menghan</creatorcontrib><creatorcontrib>Laskaratos, Achilleas</creatorcontrib><creatorcontrib>Xu, Fuqiang</creatorcontrib><creatorcontrib>Luo, Sarah Xinwei</creatorcontrib><creatorcontrib>Jung, Sangyong</creatorcontrib><creatorcontrib>Augustine, George J.</creatorcontrib><creatorcontrib>Fu, Yu</creatorcontrib><title>A neural circuit for excessive feeding driven by environmental context in mice</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>NAT NEUROSCI</addtitle><addtitle>Nat Neurosci</addtitle><description>Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how environmental context drives non-homeostatic feeding is elusive. Here, we identify a population of somatostatin (
TN
SST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of
TN
SST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and
TN
SST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting
TN
SST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding.
Tuberal nucleus SST
+
neurons respond to palatable food. The activity of these SST neurons together with their plastic inputs from the ventral subiculum play critical roles in contextually conditioned feeding.</description><subject>631/378/1488/1562</subject><subject>631/378/3920</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain research</subject><subject>Circuits</subject><subject>Cognitive ability</subject><subject>Context</subject><subject>Cues</subject><subject>Environmental factors</subject><subject>Feeding</subject><subject>Feeding Behavior - physiology</subject><subject>Food</subject><subject>Food habits</subject><subject>Hippocampus</subject><subject>Hypothalamus</subject><subject>Hypothalamus - physiology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Mice</subject><subject>Neural circuitry</subject><subject>Neural Pathways - 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Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohammad, Hasan</au><au>Senol, Esra</au><au>Graf, Martin</au><au>Lee, Chun-Yao</au><au>Li, Qin</au><au>Liu, Qing</au><au>Yeo, Xin Yi</au><au>Wang, Menghan</au><au>Laskaratos, Achilleas</au><au>Xu, Fuqiang</au><au>Luo, Sarah Xinwei</au><au>Jung, Sangyong</au><au>Augustine, George J.</au><au>Fu, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A neural circuit for excessive feeding driven by environmental context in mice</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><stitle>NAT NEUROSCI</stitle><addtitle>Nat Neurosci</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>24</volume><issue>8</issue><spage>1132</spage><epage>1141</epage><pages>1132-1141</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><abstract>Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how environmental context drives non-homeostatic feeding is elusive. Here, we identify a population of somatostatin (
TN
SST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of
TN
SST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and
TN
SST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting
TN
SST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding.
Tuberal nucleus SST
+
neurons respond to palatable food. The activity of these SST neurons together with their plastic inputs from the ventral subiculum play critical roles in contextually conditioned feeding.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>34168339</pmid><doi>10.1038/s41593-021-00875-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1546-4564</orcidid><orcidid>https://orcid.org/0000-0001-7408-7485</orcidid><orcidid>https://orcid.org/0000-0003-4878-0520</orcidid><orcidid>https://orcid.org/0000-0002-5309-4034</orcidid><orcidid>https://orcid.org/0000-0002-2456-5781</orcidid><orcidid>https://orcid.org/0000-0002-9226-1982</orcidid><orcidid>https://orcid.org/0000-0001-9859-1184</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Nature neuroscience, 2021-08, Vol.24 (8), p.1132-1141 |
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| language | eng |
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| source | MEDLINE; Nature; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Alma/SFX Local Collection |
| subjects | 631/378/1488/1562 631/378/3920 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain research Circuits Cognitive ability Context Cues Environmental factors Feeding Feeding Behavior - physiology Food Food habits Hippocampus Hypothalamus Hypothalamus - physiology Life Sciences & Biomedicine Male Mice Neural circuitry Neural Pathways - physiology Neurobiology Neurons Neurons - physiology Neurosciences Neurosciences & Neurology Obesity Physiological aspects Physiological effects Physiology Psychological aspects Science & Technology Somatostatin Somatostatin - metabolism Subiculum Synaptic transmission |
| title | A neural circuit for excessive feeding driven by environmental context in mice |
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