Retentive efficacy, antimicrobial and cytotoxicity comparisons between different types of commercial and experimental denture adhesives with antifungal action
The effect of the addition of nystatin and an alternative antifungal derived from pyrazoles in different commercial denture adhesives on their retentive efficacy, cytotoxicity and antimicrobial activity against Candida albicans was evaluated. Commercial denture adhesives were prepared with the inclu...
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| Veröffentlicht in: | Dental Materials Journal 2021/07/25, Vol.40(4), pp.1055-1062 |
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| creator | Simone Gomes Dias de OLIVEIRA MARTOS, Josué CARVALHO, Rodrigo Varella de Cláudio Martin Pereira de PEREIRA LUND, Rafael Guerra PIVA, Evandro |
| description | The effect of the addition of nystatin and an alternative antifungal derived from pyrazoles in different commercial denture adhesives on their retentive efficacy, cytotoxicity and antimicrobial activity against Candida albicans was evaluated. Commercial denture adhesives were prepared with the inclusion of nystatin and 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamide (pyrazole) in three concentrations: 23.78 %w/w, 3.02 %w/w, and 0.31 %w/w (0.015 g, 0.0015 g, and 0.00015 g, respectively). The retentive efficacy was tested observing the influence of the medium, type of commercial denture type and the test condition (dipping). The antifungal action through disk diffusion and direct contact tests at 1, 4, 8 and 12 h and cytotoxic activity was evaluated in mouse fibroblasts (NIH/3T3) by the MTT reduction colorimetric assay. The addition of pyrazole and nystatin in commercial denture adhesives did not affect retentive efficacy rates and enhanced antifungal actions against Candida albicans. Results show a possibility of using denture adhesives as a delivery system for commercial antifungals (Nystatin) or pyrazole, with the second concentration (1,560 µg–3.02 %w/w) as the most efficient. |
| doi_str_mv | 10.4012/dmj.2020-262 |
| format | Article |
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Commercial denture adhesives were prepared with the inclusion of nystatin and 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamide (pyrazole) in three concentrations: 23.78 %w/w, 3.02 %w/w, and 0.31 %w/w (0.015 g, 0.0015 g, and 0.00015 g, respectively). The retentive efficacy was tested observing the influence of the medium, type of commercial denture type and the test condition (dipping). The antifungal action through disk diffusion and direct contact tests at 1, 4, 8 and 12 h and cytotoxic activity was evaluated in mouse fibroblasts (NIH/3T3) by the MTT reduction colorimetric assay. The addition of pyrazole and nystatin in commercial denture adhesives did not affect retentive efficacy rates and enhanced antifungal actions against Candida albicans. Results show a possibility of using denture adhesives as a delivery system for commercial antifungals (Nystatin) or pyrazole, with the second concentration (1,560 µg–3.02 %w/w) as the most efficient.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2020-262</identifier><identifier>PMID: 33883326</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Adhesives ; Antifungal activity ; Antifungal agents ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Candida albicans ; Colorimetry ; Cytotoxicity ; Dental materials ; Denture adhesives ; Dentures ; Disk diffusion antimicrobial tests ; Fibroblasts ; Fungicides ; Nystatin ; Prostheses ; Pyrazole ; Pyrazoles ; Toxicity ; Toxicity tests</subject><ispartof>Dental Materials Journal, 2021/07/25, Vol.40(4), pp.1055-1062</ispartof><rights>2021 The Japanese Society for Dental Materials and Devices</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-e342ec013526c0dd8a6f122142ccab65734819192bfeea8bf3a5f0e58595efe23</citedby><cites>FETCH-LOGICAL-c482t-e342ec013526c0dd8a6f122142ccab65734819192bfeea8bf3a5f0e58595efe23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33883326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simone Gomes Dias de OLIVEIRA</creatorcontrib><creatorcontrib>MARTOS, Josué</creatorcontrib><creatorcontrib>CARVALHO, Rodrigo Varella de</creatorcontrib><creatorcontrib>Cláudio Martin Pereira de PEREIRA</creatorcontrib><creatorcontrib>LUND, Rafael Guerra</creatorcontrib><creatorcontrib>PIVA, Evandro</creatorcontrib><title>Retentive efficacy, antimicrobial and cytotoxicity comparisons between different types of commercial and experimental denture adhesives with antifungal action</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>The effect of the addition of nystatin and an alternative antifungal derived from pyrazoles in different commercial denture adhesives on their retentive efficacy, cytotoxicity and antimicrobial activity against Candida albicans was evaluated. Commercial denture adhesives were prepared with the inclusion of nystatin and 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamide (pyrazole) in three concentrations: 23.78 %w/w, 3.02 %w/w, and 0.31 %w/w (0.015 g, 0.0015 g, and 0.00015 g, respectively). The retentive efficacy was tested observing the influence of the medium, type of commercial denture type and the test condition (dipping). The antifungal action through disk diffusion and direct contact tests at 1, 4, 8 and 12 h and cytotoxic activity was evaluated in mouse fibroblasts (NIH/3T3) by the MTT reduction colorimetric assay. The addition of pyrazole and nystatin in commercial denture adhesives did not affect retentive efficacy rates and enhanced antifungal actions against Candida albicans. Results show a possibility of using denture adhesives as a delivery system for commercial antifungals (Nystatin) or pyrazole, with the second concentration (1,560 µg–3.02 %w/w) as the most efficient.</description><subject>Adhesives</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Candida albicans</subject><subject>Colorimetry</subject><subject>Cytotoxicity</subject><subject>Dental materials</subject><subject>Denture adhesives</subject><subject>Dentures</subject><subject>Disk diffusion antimicrobial tests</subject><subject>Fibroblasts</subject><subject>Fungicides</subject><subject>Nystatin</subject><subject>Prostheses</subject><subject>Pyrazole</subject><subject>Pyrazoles</subject><subject>Toxicity</subject><subject>Toxicity tests</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9kUtv3CAURlHVqJkm3XVdIXUbpzxtZplEfUmRKkXJGmF8yTAaGxdwE_-Z_tbgTGY2XHE5nCv4EPpMyaUglH3r-u0lI4xUrGbv0IoqRSvKa_oerQhTTSWkaE7Rx5S2hIh1rdQHdMq5UpyzeoX-30GGIft_gME5b42dL7Apjd7bGFpvdmXXYTvnkMOztz7P2IZ-NNGnMCTcQn4CGHDnnYNYTDjPIyQc3IL1EO1BAc8jRN8XpDS6UqYI2HQbSGV4wk8-b14Hu2l4XK7Y7MNwjk6c2SX49FbP0MOP7_c3v6rbPz9_31zdVlYolivggoEllEtWW9J1ytSOMkYFs9a0tWy4UHRN16x1AEa1jhvpCEgl1xIcMH6Gvu69Ywx_J0hZb8MUhzJSMykb1hBRN4W62FPla1KK4PRYXmTirCnRSxi6hKGXMHQJo-Bf3qRT20N3hA-_X4DrPbBN2TzCETAxe7uDV5so5mU5WI-HdmOihoG_ALbloYw</recordid><startdate>20210725</startdate><enddate>20210725</enddate><creator>Simone Gomes Dias de OLIVEIRA</creator><creator>MARTOS, Josué</creator><creator>CARVALHO, Rodrigo Varella de</creator><creator>Cláudio Martin Pereira de PEREIRA</creator><creator>LUND, Rafael Guerra</creator><creator>PIVA, Evandro</creator><general>The Japanese Society for Dental Materials and Devices</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>20210725</creationdate><title>Retentive efficacy, antimicrobial and cytotoxicity comparisons between different types of commercial and experimental denture adhesives with antifungal action</title><author>Simone Gomes Dias de OLIVEIRA ; MARTOS, Josué ; CARVALHO, Rodrigo Varella de ; Cláudio Martin Pereira de PEREIRA ; LUND, Rafael Guerra ; PIVA, Evandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-e342ec013526c0dd8a6f122142ccab65734819192bfeea8bf3a5f0e58595efe23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adhesives</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Candida albicans</topic><topic>Colorimetry</topic><topic>Cytotoxicity</topic><topic>Dental materials</topic><topic>Denture adhesives</topic><topic>Dentures</topic><topic>Disk diffusion antimicrobial tests</topic><topic>Fibroblasts</topic><topic>Fungicides</topic><topic>Nystatin</topic><topic>Prostheses</topic><topic>Pyrazole</topic><topic>Pyrazoles</topic><topic>Toxicity</topic><topic>Toxicity tests</topic><toplevel>online_resources</toplevel><creatorcontrib>Simone Gomes Dias de OLIVEIRA</creatorcontrib><creatorcontrib>MARTOS, Josué</creatorcontrib><creatorcontrib>CARVALHO, Rodrigo Varella de</creatorcontrib><creatorcontrib>Cláudio Martin Pereira de PEREIRA</creatorcontrib><creatorcontrib>LUND, Rafael Guerra</creatorcontrib><creatorcontrib>PIVA, Evandro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Dental Materials Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simone Gomes Dias de OLIVEIRA</au><au>MARTOS, Josué</au><au>CARVALHO, Rodrigo Varella de</au><au>Cláudio Martin Pereira de PEREIRA</au><au>LUND, Rafael Guerra</au><au>PIVA, Evandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retentive efficacy, antimicrobial and cytotoxicity comparisons between different types of commercial and experimental denture adhesives with antifungal action</atitle><jtitle>Dental Materials Journal</jtitle><addtitle>Dent. Mater. J.</addtitle><date>2021-07-25</date><risdate>2021</risdate><volume>40</volume><issue>4</issue><spage>1055</spage><epage>1062</epage><pages>1055-1062</pages><artnum>2020-262</artnum><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>The effect of the addition of nystatin and an alternative antifungal derived from pyrazoles in different commercial denture adhesives on their retentive efficacy, cytotoxicity and antimicrobial activity against Candida albicans was evaluated. Commercial denture adhesives were prepared with the inclusion of nystatin and 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamide (pyrazole) in three concentrations: 23.78 %w/w, 3.02 %w/w, and 0.31 %w/w (0.015 g, 0.0015 g, and 0.00015 g, respectively). The retentive efficacy was tested observing the influence of the medium, type of commercial denture type and the test condition (dipping). The antifungal action through disk diffusion and direct contact tests at 1, 4, 8 and 12 h and cytotoxic activity was evaluated in mouse fibroblasts (NIH/3T3) by the MTT reduction colorimetric assay. The addition of pyrazole and nystatin in commercial denture adhesives did not affect retentive efficacy rates and enhanced antifungal actions against Candida albicans. Results show a possibility of using denture adhesives as a delivery system for commercial antifungals (Nystatin) or pyrazole, with the second concentration (1,560 µg–3.02 %w/w) as the most efficient.</abstract><cop>Japan</cop><pub>The Japanese Society for Dental Materials and Devices</pub><pmid>33883326</pmid><doi>10.4012/dmj.2020-262</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adhesives Antifungal activity Antifungal agents Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Candida albicans Colorimetry Cytotoxicity Dental materials Denture adhesives Dentures Disk diffusion antimicrobial tests Fibroblasts Fungicides Nystatin Prostheses Pyrazole Pyrazoles Toxicity Toxicity tests |
| title | Retentive efficacy, antimicrobial and cytotoxicity comparisons between different types of commercial and experimental denture adhesives with antifungal action |
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