The use of progestins in equine medicine: A review
Summary Progesterone is in constant fluctuation throughout the lifespan of the horse. As a key regulator of the hypothalamic–pituitary–gonadal axis, progesterone is involved in numerous aspects of reproduction. Synthetic analogs of progesterone, deemed progestins, are widely available to industry to...
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| Veröffentlicht in: | Equine veterinary education 2021-09, Vol.33 (9), p.494-504 |
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| container_title | Equine veterinary education |
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| creator | Fedorka, C. E. Troedsson, M. H. T. |
| description | Summary
Progesterone is in constant fluctuation throughout the lifespan of the horse. As a key regulator of the hypothalamic–pituitary–gonadal axis, progesterone is involved in numerous aspects of reproduction. Synthetic analogs of progesterone, deemed progestins, are widely available to industry to act as progestogenic within the reproductive tract, although few are bioactive in the horse. Utilised to suppress oestrous, delay ovulation, maintain pregnancy, and for behavioural modifications, progestins are a commonly administered class of pharmaceuticals in veterinary medicine. In this review, we discuss the progestins available to equine industry, in addition to assessing efficacy, pharmacokinetics, and potential side effects following administration of each. |
| doi_str_mv | 10.1111/eve.13332 |
| format | Article |
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Progesterone is in constant fluctuation throughout the lifespan of the horse. As a key regulator of the hypothalamic–pituitary–gonadal axis, progesterone is involved in numerous aspects of reproduction. Synthetic analogs of progesterone, deemed progestins, are widely available to industry to act as progestogenic within the reproductive tract, although few are bioactive in the horse. Utilised to suppress oestrous, delay ovulation, maintain pregnancy, and for behavioural modifications, progestins are a commonly administered class of pharmaceuticals in veterinary medicine. In this review, we discuss the progestins available to equine industry, in addition to assessing efficacy, pharmacokinetics, and potential side effects following administration of each.</description><identifier>ISSN: 0957-7734</identifier><identifier>EISSN: 2042-3292</identifier><identifier>DOI: 10.1111/eve.13332</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>altrenogest ; Estrus ; horse ; Horses ; Hypothalamus ; Life span ; Medicine ; Ovulation ; Pharmacokinetics ; Pituitary ; Progesterone ; Progestin ; reproduction ; Reproductive system ; Side effects ; Veterinary medicine</subject><ispartof>Equine veterinary education, 2021-09, Vol.33 (9), p.494-504</ispartof><rights>2020 EVJ Ltd</rights><rights>Copyright © 2021 EVJ Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2972-fb0d478a43ceeb99c832981e3b6bd3add74874d016a21e6f3de0a2449f4326133</citedby><cites>FETCH-LOGICAL-c2972-fb0d478a43ceeb99c832981e3b6bd3add74874d016a21e6f3de0a2449f4326133</cites><orcidid>0000-0003-0518-4809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feve.13332$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feve.13332$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Fedorka, C. E.</creatorcontrib><creatorcontrib>Troedsson, M. H. T.</creatorcontrib><title>The use of progestins in equine medicine: A review</title><title>Equine veterinary education</title><description>Summary
Progesterone is in constant fluctuation throughout the lifespan of the horse. As a key regulator of the hypothalamic–pituitary–gonadal axis, progesterone is involved in numerous aspects of reproduction. Synthetic analogs of progesterone, deemed progestins, are widely available to industry to act as progestogenic within the reproductive tract, although few are bioactive in the horse. Utilised to suppress oestrous, delay ovulation, maintain pregnancy, and for behavioural modifications, progestins are a commonly administered class of pharmaceuticals in veterinary medicine. In this review, we discuss the progestins available to equine industry, in addition to assessing efficacy, pharmacokinetics, and potential side effects following administration of each.</description><subject>altrenogest</subject><subject>Estrus</subject><subject>horse</subject><subject>Horses</subject><subject>Hypothalamus</subject><subject>Life span</subject><subject>Medicine</subject><subject>Ovulation</subject><subject>Pharmacokinetics</subject><subject>Pituitary</subject><subject>Progesterone</subject><subject>Progestin</subject><subject>reproduction</subject><subject>Reproductive system</subject><subject>Side effects</subject><subject>Veterinary medicine</subject><issn>0957-7734</issn><issn>2042-3292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kD9PwzAQxS0EEqEw8A0sMTGktc9OHLNVVfgjVWIprFYSX8BVm7Q2adVvjyGs3HI3_O7uvUfILWdTHmuGB5xyIQSckQSYhFSAhnOSMJ2pVCkhL8lVCGvGMqlAJQRWn0iHgLRv6c73Hxi-XBeo6yjuB9ch3aJ1TRwe6Jx6PDg8XpOLttoEvPnrE_L2WK4Wz-ny9ellMV-mDWgFaVszK1VRSdEg1lo3RZRScBR1XltRWatkoaRlPK-AY94Ki6wCKXUrBeTRw4TcjXejrv0QhZl1P_guvjSQZYpxJkQeqfuRanwfgsfW7LzbVv5kODM_kZgYifmNJLKzkT26DZ7-B035Xo4b3yvkYFk</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Fedorka, C. E.</creator><creator>Troedsson, M. H. T.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><orcidid>https://orcid.org/0000-0003-0518-4809</orcidid></search><sort><creationdate>202109</creationdate><title>The use of progestins in equine medicine: A review</title><author>Fedorka, C. E. ; Troedsson, M. H. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2972-fb0d478a43ceeb99c832981e3b6bd3add74874d016a21e6f3de0a2449f4326133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>altrenogest</topic><topic>Estrus</topic><topic>horse</topic><topic>Horses</topic><topic>Hypothalamus</topic><topic>Life span</topic><topic>Medicine</topic><topic>Ovulation</topic><topic>Pharmacokinetics</topic><topic>Pituitary</topic><topic>Progesterone</topic><topic>Progestin</topic><topic>reproduction</topic><topic>Reproductive system</topic><topic>Side effects</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fedorka, C. E.</creatorcontrib><creatorcontrib>Troedsson, M. H. T.</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><jtitle>Equine veterinary education</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fedorka, C. E.</au><au>Troedsson, M. H. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of progestins in equine medicine: A review</atitle><jtitle>Equine veterinary education</jtitle><date>2021-09</date><risdate>2021</risdate><volume>33</volume><issue>9</issue><spage>494</spage><epage>504</epage><pages>494-504</pages><issn>0957-7734</issn><eissn>2042-3292</eissn><abstract>Summary
Progesterone is in constant fluctuation throughout the lifespan of the horse. As a key regulator of the hypothalamic–pituitary–gonadal axis, progesterone is involved in numerous aspects of reproduction. Synthetic analogs of progesterone, deemed progestins, are widely available to industry to act as progestogenic within the reproductive tract, although few are bioactive in the horse. Utilised to suppress oestrous, delay ovulation, maintain pregnancy, and for behavioural modifications, progestins are a commonly administered class of pharmaceuticals in veterinary medicine. In this review, we discuss the progestins available to equine industry, in addition to assessing efficacy, pharmacokinetics, and potential side effects following administration of each.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/eve.13332</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0518-4809</orcidid></addata></record> |
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| ispartof | Equine veterinary education, 2021-09, Vol.33 (9), p.494-504 |
| issn | 0957-7734 2042-3292 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | altrenogest Estrus horse Horses Hypothalamus Life span Medicine Ovulation Pharmacokinetics Pituitary Progesterone Progestin reproduction Reproductive system Side effects Veterinary medicine |
| title | The use of progestins in equine medicine: A review |
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