IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection
Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels of HBV infection vary remarkably among persons rangin...
Gespeichert in:
| Veröffentlicht in: | Jundishapur journal of microbiology 2021-04, Vol.14 (4), p.1-6 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6 |
|---|---|
| container_issue | 4 |
| container_start_page | 1 |
| container_title | Jundishapur journal of microbiology |
| container_volume | 14 |
| creator | Mahavar, Neda Naseri, Mohsen Anani Sarab, Gholamreza Fereidouni, Mohammad Ziaee, Masood safari, hamidreza Naghizadeh, Mohammad Sadegh Tane, Abdolghader Mahdavi, Roya |
| description | Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels of HBV infection vary remarkably among persons ranging from the spontaneous deletion of infection to persistent infection. Objective: The present study aimed to evaluate the association of single nucleotide polymorphisms IL10-1082 with HBV clearance. Methods: Sixty subjects with Chronic Hepatitis B (CHB) infection and 60 subjects who spontaneously recovered HBV were enrolled in the study. The IL-10-1082 polymorphisms were determined by Polymerase Chain Reaction with Restriction Fragment Length Polymorphism (PCR–RFLP). Results: The clearance of HBV infection demonstrated a significant association with IL-10-1082 polymorphisms in the GG genotype (P = 0.03), while there was no association with other genotypes. Reduced risk of chronic hepatitis B infection was associated with IL-10-1082 GG (OR: 2.33, 95% CI: 1.07 - 5.09). Besides, IL-10-1082 A/G alleles did not differ clearly between the two study groups (P = 0.07) Conclusions: The IL-10-1082 polymorphisms may be associated with a reduced risk of CHB infection and recovery after HBV infection. |
| doi_str_mv | 10.5812/jjm.93003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2556885718</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2556885718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2073-c187544ef68199655cbd2ebbf4550bbc4665ffd042878a4c31d2673d65aa18403</originalsourceid><addsrcrecordid>eNotkEtLAzEQx4MoWGoPfoOAF3vYNu_NHmvpCxb0oN4kZLOJZuk-TLZCv73bx8Awf5gfM_AD4BGjGZeYzKuqnmUUIXoDRgQhmTAs8O01U8H4PZjEWKFTpUgyMgJfuzzBCA4tCVzMN_A5RCwHPhNT-Nbuj3Ubuh8fa-gjXDlnTe__LPQNXO6tDr75hlvb6d73w_4FfvpwiHDXnLm2eQB3Tu-jnVznGHysV-_LbZK_bnbLRZ4YglKaGCxTzph1QuIsE5yboiS2KBzjHBWFYUJw50rEiEylZobikoiUloJrjSVDdAyeLne70P4ebOxV1R5CM7xUhHMhJU-xHKjphTKhjTFYp7rgax2OCiN1EqgGgeoskP4DB8peEg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2556885718</pqid></control><display><type>article</type><title>IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Mahavar, Neda ; Naseri, Mohsen ; Anani Sarab, Gholamreza ; Fereidouni, Mohammad ; Ziaee, Masood ; safari, hamidreza ; Naghizadeh, Mohammad Sadegh ; Tane, Abdolghader ; Mahdavi, Roya</creator><creatorcontrib>Mahavar, Neda ; Naseri, Mohsen ; Anani Sarab, Gholamreza ; Fereidouni, Mohammad ; Ziaee, Masood ; safari, hamidreza ; Naghizadeh, Mohammad Sadegh ; Tane, Abdolghader ; Mahdavi, Roya</creatorcontrib><description>Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels of HBV infection vary remarkably among persons ranging from the spontaneous deletion of infection to persistent infection. Objective: The present study aimed to evaluate the association of single nucleotide polymorphisms IL10-1082 with HBV clearance. Methods: Sixty subjects with Chronic Hepatitis B (CHB) infection and 60 subjects who spontaneously recovered HBV were enrolled in the study. The IL-10-1082 polymorphisms were determined by Polymerase Chain Reaction with Restriction Fragment Length Polymorphism (PCR–RFLP). Results: The clearance of HBV infection demonstrated a significant association with IL-10-1082 polymorphisms in the GG genotype (P = 0.03), while there was no association with other genotypes. Reduced risk of chronic hepatitis B infection was associated with IL-10-1082 GG (OR: 2.33, 95% CI: 1.07 - 5.09). Besides, IL-10-1082 A/G alleles did not differ clearly between the two study groups (P = 0.07) Conclusions: The IL-10-1082 polymorphisms may be associated with a reduced risk of CHB infection and recovery after HBV infection.</description><identifier>ISSN: 2008-3645</identifier><identifier>EISSN: 2008-4161</identifier><identifier>DOI: 10.5812/jjm.93003</identifier><language>eng</language><publisher>Ahvaz: Ahvaz Jundishapur University of Medical Sciences</publisher><subject>Antigens ; Cytokines ; Enzymes ; Genotype & phenotype ; Haplotypes ; Hepatitis B ; Infections ; Interleukin 10 ; Liver cancer ; Polymerase chain reaction ; Polymorphism ; Statistical analysis</subject><ispartof>Jundishapur journal of microbiology, 2021-04, Vol.14 (4), p.1-6</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2073-c187544ef68199655cbd2ebbf4550bbc4665ffd042878a4c31d2673d65aa18403</citedby><cites>FETCH-LOGICAL-c2073-c187544ef68199655cbd2ebbf4550bbc4665ffd042878a4c31d2673d65aa18403</cites><orcidid>0000-0003-0218-6833</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Mahavar, Neda</creatorcontrib><creatorcontrib>Naseri, Mohsen</creatorcontrib><creatorcontrib>Anani Sarab, Gholamreza</creatorcontrib><creatorcontrib>Fereidouni, Mohammad</creatorcontrib><creatorcontrib>Ziaee, Masood</creatorcontrib><creatorcontrib>safari, hamidreza</creatorcontrib><creatorcontrib>Naghizadeh, Mohammad Sadegh</creatorcontrib><creatorcontrib>Tane, Abdolghader</creatorcontrib><creatorcontrib>Mahdavi, Roya</creatorcontrib><title>IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection</title><title>Jundishapur journal of microbiology</title><description>Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels of HBV infection vary remarkably among persons ranging from the spontaneous deletion of infection to persistent infection. Objective: The present study aimed to evaluate the association of single nucleotide polymorphisms IL10-1082 with HBV clearance. Methods: Sixty subjects with Chronic Hepatitis B (CHB) infection and 60 subjects who spontaneously recovered HBV were enrolled in the study. The IL-10-1082 polymorphisms were determined by Polymerase Chain Reaction with Restriction Fragment Length Polymorphism (PCR–RFLP). Results: The clearance of HBV infection demonstrated a significant association with IL-10-1082 polymorphisms in the GG genotype (P = 0.03), while there was no association with other genotypes. Reduced risk of chronic hepatitis B infection was associated with IL-10-1082 GG (OR: 2.33, 95% CI: 1.07 - 5.09). Besides, IL-10-1082 A/G alleles did not differ clearly between the two study groups (P = 0.07) Conclusions: The IL-10-1082 polymorphisms may be associated with a reduced risk of CHB infection and recovery after HBV infection.</description><subject>Antigens</subject><subject>Cytokines</subject><subject>Enzymes</subject><subject>Genotype & phenotype</subject><subject>Haplotypes</subject><subject>Hepatitis B</subject><subject>Infections</subject><subject>Interleukin 10</subject><subject>Liver cancer</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Statistical analysis</subject><issn>2008-3645</issn><issn>2008-4161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNotkEtLAzEQx4MoWGoPfoOAF3vYNu_NHmvpCxb0oN4kZLOJZuk-TLZCv73bx8Awf5gfM_AD4BGjGZeYzKuqnmUUIXoDRgQhmTAs8O01U8H4PZjEWKFTpUgyMgJfuzzBCA4tCVzMN_A5RCwHPhNT-Nbuj3Ubuh8fa-gjXDlnTe__LPQNXO6tDr75hlvb6d73w_4FfvpwiHDXnLm2eQB3Tu-jnVznGHysV-_LbZK_bnbLRZ4YglKaGCxTzph1QuIsE5yboiS2KBzjHBWFYUJw50rEiEylZobikoiUloJrjSVDdAyeLne70P4ebOxV1R5CM7xUhHMhJU-xHKjphTKhjTFYp7rgax2OCiN1EqgGgeoskP4DB8peEg</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Mahavar, Neda</creator><creator>Naseri, Mohsen</creator><creator>Anani Sarab, Gholamreza</creator><creator>Fereidouni, Mohammad</creator><creator>Ziaee, Masood</creator><creator>safari, hamidreza</creator><creator>Naghizadeh, Mohammad Sadegh</creator><creator>Tane, Abdolghader</creator><creator>Mahdavi, Roya</creator><general>Ahvaz Jundishapur University of Medical Sciences</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-0218-6833</orcidid></search><sort><creationdate>20210401</creationdate><title>IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection</title><author>Mahavar, Neda ; Naseri, Mohsen ; Anani Sarab, Gholamreza ; Fereidouni, Mohammad ; Ziaee, Masood ; safari, hamidreza ; Naghizadeh, Mohammad Sadegh ; Tane, Abdolghader ; Mahdavi, Roya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2073-c187544ef68199655cbd2ebbf4550bbc4665ffd042878a4c31d2673d65aa18403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antigens</topic><topic>Cytokines</topic><topic>Enzymes</topic><topic>Genotype & phenotype</topic><topic>Haplotypes</topic><topic>Hepatitis B</topic><topic>Infections</topic><topic>Interleukin 10</topic><topic>Liver cancer</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahavar, Neda</creatorcontrib><creatorcontrib>Naseri, Mohsen</creatorcontrib><creatorcontrib>Anani Sarab, Gholamreza</creatorcontrib><creatorcontrib>Fereidouni, Mohammad</creatorcontrib><creatorcontrib>Ziaee, Masood</creatorcontrib><creatorcontrib>safari, hamidreza</creatorcontrib><creatorcontrib>Naghizadeh, Mohammad Sadegh</creatorcontrib><creatorcontrib>Tane, Abdolghader</creatorcontrib><creatorcontrib>Mahdavi, Roya</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Jundishapur journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahavar, Neda</au><au>Naseri, Mohsen</au><au>Anani Sarab, Gholamreza</au><au>Fereidouni, Mohammad</au><au>Ziaee, Masood</au><au>safari, hamidreza</au><au>Naghizadeh, Mohammad Sadegh</au><au>Tane, Abdolghader</au><au>Mahdavi, Roya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection</atitle><jtitle>Jundishapur journal of microbiology</jtitle><date>2021-04-01</date><risdate>2021</risdate><volume>14</volume><issue>4</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2008-3645</issn><eissn>2008-4161</eissn><abstract>Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels of HBV infection vary remarkably among persons ranging from the spontaneous deletion of infection to persistent infection. Objective: The present study aimed to evaluate the association of single nucleotide polymorphisms IL10-1082 with HBV clearance. Methods: Sixty subjects with Chronic Hepatitis B (CHB) infection and 60 subjects who spontaneously recovered HBV were enrolled in the study. The IL-10-1082 polymorphisms were determined by Polymerase Chain Reaction with Restriction Fragment Length Polymorphism (PCR–RFLP). Results: The clearance of HBV infection demonstrated a significant association with IL-10-1082 polymorphisms in the GG genotype (P = 0.03), while there was no association with other genotypes. Reduced risk of chronic hepatitis B infection was associated with IL-10-1082 GG (OR: 2.33, 95% CI: 1.07 - 5.09). Besides, IL-10-1082 A/G alleles did not differ clearly between the two study groups (P = 0.07) Conclusions: The IL-10-1082 polymorphisms may be associated with a reduced risk of CHB infection and recovery after HBV infection.</abstract><cop>Ahvaz</cop><pub>Ahvaz Jundishapur University of Medical Sciences</pub><doi>10.5812/jjm.93003</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0218-6833</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2008-3645 |
| ispartof | Jundishapur journal of microbiology, 2021-04, Vol.14 (4), p.1-6 |
| issn | 2008-3645 2008-4161 |
| language | eng |
| recordid | cdi_proquest_journals_2556885718 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antigens Cytokines Enzymes Genotype & phenotype Haplotypes Hepatitis B Infections Interleukin 10 Liver cancer Polymerase chain reaction Polymorphism Statistical analysis |
| title | IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T22%3A56%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IL-10%20-1082%20A/G%20(rs1800896)%20Polymorphism%20is%20Effective%20in%20Clearing%20Hepatitis%20B%20Virus%20Infection&rft.jtitle=Jundishapur%20journal%20of%20microbiology&rft.au=Mahavar,%20Neda&rft.date=2021-04-01&rft.volume=14&rft.issue=4&rft.spage=1&rft.epage=6&rft.pages=1-6&rft.issn=2008-3645&rft.eissn=2008-4161&rft_id=info:doi/10.5812/jjm.93003&rft_dat=%3Cproquest_cross%3E2556885718%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2556885718&rft_id=info:pmid/&rfr_iscdi=true |