Understanding the significance variables for fabrication of fish gelatin nanoparticles by Plackett-Burman design
The aim of this experiment is to screen and to understand the process variables on the fabrication of fish gelatin nanoparticles by using quality-design approach. The most influencing process variables were screened by using Plackett-Burman design. Mean particles size, size distribution, and zeta po...
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| Veröffentlicht in: | IOP conference series. Materials Science and Engineering 2018-01, Vol.290 (1), p.12006 |
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| creator | Subara, Deni Jaswir, Irwandi Rashid Alkhatib, Maan Fahmi Noorbatcha, Ibrahim Ali |
| description | The aim of this experiment is to screen and to understand the process variables on the fabrication of fish gelatin nanoparticles by using quality-design approach. The most influencing process variables were screened by using Plackett-Burman design. Mean particles size, size distribution, and zeta potential were found in the range 240±9.76 nm, 0.3, and −9 mV, respectively. Statistical results explained that concentration of acetone, pH of solution during precipitation step and volume of cross linker had a most significant effect on particles size of fish gelatin nanoparticles. It was found that, time and chemical consuming is lower than previous research. This study revealed the potential of quality-by design in understanding the effects of process variables on the fish gelatin nanoparticles production. |
| doi_str_mv | 10.1088/1757-899X/290/1/012006 |
| format | Article |
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| subjects | Chemical precipitation Fish Gelatin Nanoparticles Particle size distribution Process variables Zeta potential |
| title | Understanding the significance variables for fabrication of fish gelatin nanoparticles by Plackett-Burman design |
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