EGFR activation limits the response of liver cancer to lenvatinib

Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options 1 . Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinases that is used for the treatment of patients with advanced HCC, but this drug has only...

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Veröffentlicht in:	Nature (London) 2021-07, Vol.595 (7869), p.730-734
Hauptverfasser:	Jin, Haojie, Shi, Yaoping, Lv, Yuanyuan, Yuan, Shengxian, Ramirez, Christel F. A., Lieftink, Cor, Wang, Liqin, Wang, Siying, Wang, Cun, Dias, Matheus Henrique, Jochems, Fleur, Yang, Yuan, Bosma, Astrid, Hijmans, E. Marielle, de Groot, Marnix H. P., Vegna, Serena, Cui, Dan, Zhou, Yangyang, Ling, Jing, Wang, Hui, Guo, Yuchen, Zheng, Xingling, Isima, Nikita, Wu, Haiqiu, Sun, Chong, Beijersbergen, Roderick L., Akkari, Leila, Zhou, Weiping, Zhai, Bo, Qin, Wenxin, Bernards, René
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/47 38/89 38/90 38/91 631/67/1059 631/67/68 96/106 Animal models Animals Antineoplastic Agents - pharmacology Cancer Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Causes of Cell culture Cell Line, Tumor CRISPR Development and progression Drug resistance Drug Resistance, Neoplasm Drug therapy Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Feedback Female Fibroblast growth factor receptors Gefitinib Gefitinib - pharmacology Genetic screening Growth factors Hepatocellular carcinoma Hepatocytes Hepatoma Humanities and Social Sciences Humans Immunocompetence Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Male Malignancy Mice Mice, Inbred BALB C Mice, Nude multidisciplinary Patients Phenylurea Compounds - pharmacology Phosphorylation Physiological aspects Quinolines - pharmacology Receptors Receptors, Fibroblast Growth Factor Science Science (multidisciplinary) Signal Transduction Tumor cell lines Tumors Tyrosine Xenograft Model Antitumor Assays Xenografts
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