Copper( i )–catalyzed intramolecular asymmetric C-arylation of acyclic β-ester amides: enantioselective formation of chiral oxindoles
A highly efficient intramolecular asymmetric C-arylation of acyclic β-ester amides is demonstrated. A CuI/chiral diamine ligand catalyzed reaction, with t -BuOLi as the necessary base in MeCN, afforded 3,3′-disubstituted chiral oxindoles with quaternary stereogenic carboncenters in high yields and g...
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| Veröffentlicht in: | Organic Chemistry Frontiers 2021-08, Vol.8 (15), p.4211-4216 |
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| container_issue | 15 |
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| container_title | Organic Chemistry Frontiers |
| container_volume | 8 |
| creator | Deng, Zhuoji Feng, Jiajie Zhou, Fengtao Ouyang, Yifan Ma, Haowen Zhou, Wei Zhang, Xinhao Cai, Qian |
| description | A highly efficient intramolecular asymmetric C-arylation of acyclic β-ester amides is demonstrated. A CuI/chiral diamine ligand catalyzed reaction, with
t
-BuOLi as the necessary base in MeCN, afforded 3,3′-disubstituted chiral oxindoles with quaternary stereogenic carboncenters in high yields and good to excellent enantioselectivities. |
| doi_str_mv | 10.1039/D1QO00568E |
| format | Article |
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| identifier | ISSN: 2052-4129 |
| ispartof | Organic Chemistry Frontiers, 2021-08, Vol.8 (15), p.4211-4216 |
| issn | 2052-4129 2052-4110 2052-4129 2052-4110 |
| language | eng |
| recordid | cdi_proquest_journals_2555308261 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Amides Asymmetry Diamines Enantiomers Organic chemistry |
| title | Copper( i )–catalyzed intramolecular asymmetric C-arylation of acyclic β-ester amides: enantioselective formation of chiral oxindoles |
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