Gallbladder-warming Decoction with Bupleurum and Scutellaria inhibits Anxiety and Depression of Rats
Objectives: To search the behavioral effect of Gallbladder-warming Decoction with Bupleurum and Scutellaria (GWBS) on anxiety and depression model rats and explore its mechanism. Methods: Twenty SD rats were randomly divided into four groups with 5 in each group: blank control group, model group, we...
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| creator | Sun, Ning Ren, Yumei Wang, Mingyu Miao, Xinyan Meng, Zhiyong Wang, Chaobo Yuan, Xiaolong Wang, Liang Fu, Chen Zhang, Weiguang Zhang, Donghan Cheng, Ran Wang, Pengyu Yang, Hao Qi, Binbin Li, Yuzhu Cai, Ruijuan Li, Xiaobing |
| description | Objectives: To search the behavioral effect of Gallbladder-warming Decoction with Bupleurum and Scutellaria (GWBS) on anxiety and depression model rats and explore its mechanism. Methods: Twenty SD rats were randomly divided into four groups with 5 in each group: blank control group, model group, weastern medicine group and GWBS group. The unpredictable chronic emotional stress method was used to induce anxiety and depression of model rats. Rats in weastern medicine group were given diazepam at 0.26 mg/kg/d and the 5 rats in GWBS group were given GWBS at 11.5g/kg/d, otherwise, the other two groups were given the same volume of normal saline once a day. The experiment lasted for 10 days, during which the general state including body weight, hair color, activity level and so on were observed and the data were recorded. The results of sucrose consumption test and the light-dark box test were also recorded during the ten days. After the experiment, the changes of histological pathologic in the hippocampus were examined, and the γ-aminobutyric acid concentration of the rat hippocampus was detected using ELISA kit. Results: Pathological results indicated that GWBS improved pyramidal cells in hippocampus keeping the disordered arrangement. In comparison of the model group, the body weights of the weastern medicine group and the GWBS group apparently increased. Besides, the retention time of the light box was significantly prolonged and the concentrations of γ-aminobutyric acid in the hippocampus were significantly promoted in the two groups. The differences above were with statistical significance (P |
| doi_str_mv | 10.1088/1755-1315/440/2/022097 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_iop_j</sourceid><recordid>TN_cdi_proquest_journals_2555203924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2555203924</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-8344913078dff226aec9849c82e2301c9ef6398cd7185b90e655e0cef944c68b3</originalsourceid><addsrcrecordid>eNqFkNFKwzAUhoMoOKevIAFvvKlN0qRNLuc2pyAITq9DliYuo2tr0jL39rZWJoLgVQ7k-_9z-AC4xOgGI85jnDEW4QSzmFIUkxgRgkR2BEaHj-PDjLJTcBbCBqE0o4kYgXyhimJVqDw3Ptopv3XlG5wZXenGVSXcuWYNb9u6MK1vt1CVOVzqtjFFobxT0JVrt3JNgJPyw5lm_wXMTO1NCH28svBZNeEcnFhVBHPx_Y7B6938ZXofPT4tHqaTx0hTlDURTygV_Y08t5aQVBktOBWaE0MShLUwNk0E13mGOVsJZFLGDNLGCkp1ylfJGFwNvbWv3lsTGrmpWl92KyVhjBGUCEI7Kh0o7asQvLGy9m6r_F5iJHujspcle3GyMyqJHIx2wesh6Kr6p3k-X_7CZJ3bDiV_oP_0fwKWNIUj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2555203924</pqid></control><display><type>article</type><title>Gallbladder-warming Decoction with Bupleurum and Scutellaria inhibits Anxiety and Depression of Rats</title><source>IOP Publishing Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>IOPscience extra</source><creator>Sun, Ning ; Ren, Yumei ; Wang, Mingyu ; Miao, Xinyan ; Meng, Zhiyong ; Wang, Chaobo ; Yuan, Xiaolong ; Wang, Liang ; Fu, Chen ; Zhang, Weiguang ; Zhang, Donghan ; Cheng, Ran ; Wang, Pengyu ; Yang, Hao ; Qi, Binbin ; Li, Yuzhu ; Cai, Ruijuan ; Li, Xiaobing</creator><creatorcontrib>Sun, Ning ; Ren, Yumei ; Wang, Mingyu ; Miao, Xinyan ; Meng, Zhiyong ; Wang, Chaobo ; Yuan, Xiaolong ; Wang, Liang ; Fu, Chen ; Zhang, Weiguang ; Zhang, Donghan ; Cheng, Ran ; Wang, Pengyu ; Yang, Hao ; Qi, Binbin ; Li, Yuzhu ; Cai, Ruijuan ; Li, Xiaobing</creatorcontrib><description>Objectives: To search the behavioral effect of Gallbladder-warming Decoction with Bupleurum and Scutellaria (GWBS) on anxiety and depression model rats and explore its mechanism. Methods: Twenty SD rats were randomly divided into four groups with 5 in each group: blank control group, model group, weastern medicine group and GWBS group. The unpredictable chronic emotional stress method was used to induce anxiety and depression of model rats. Rats in weastern medicine group were given diazepam at 0.26 mg/kg/d and the 5 rats in GWBS group were given GWBS at 11.5g/kg/d, otherwise, the other two groups were given the same volume of normal saline once a day. The experiment lasted for 10 days, during which the general state including body weight, hair color, activity level and so on were observed and the data were recorded. The results of sucrose consumption test and the light-dark box test were also recorded during the ten days. After the experiment, the changes of histological pathologic in the hippocampus were examined, and the γ-aminobutyric acid concentration of the rat hippocampus was detected using ELISA kit. Results: Pathological results indicated that GWBS improved pyramidal cells in hippocampus keeping the disordered arrangement. In comparison of the model group, the body weights of the weastern medicine group and the GWBS group apparently increased. Besides, the retention time of the light box was significantly prolonged and the concentrations of γ-aminobutyric acid in the hippocampus were significantly promoted in the two groups. The differences above were with statistical significance (P<0.05). In addition, the sucrose consumption values were improved markedly. Conclusion: GWBS, the agent of relieving the depressed liver and resolving phlegm, makes a difference in treatment of anxiety and depression rats and its mechanism may be related to the increase of GABA concentration in hippocampus.</description><identifier>ISSN: 1755-1307</identifier><identifier>EISSN: 1755-1315</identifier><identifier>DOI: 10.1088/1755-1315/440/2/022097</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Anxiety ; Benzodiazepines ; Body weight ; Bupleurum ; Consumption ; Diazepam ; Gallbladder ; Hippocampus ; Lightboxes ; Medicine ; Mental depression ; Pyramidal cells ; Reagents ; Retention time ; Scutellaria ; Sucrose ; γ-Aminobutyric acid</subject><ispartof>IOP conference series. Earth and environmental science, 2020-02, Vol.440 (2), p.22097</ispartof><rights>Published under licence by IOP Publishing Ltd</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c407t-8344913078dff226aec9849c82e2301c9ef6398cd7185b90e655e0cef944c68b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1755-1315/440/2/022097/pdf$$EPDF$$P50$$Giop$$Hfree_for_read</linktopdf><link.rule.ids>314,776,780,27901,27902,38845,38867,53815,53842</link.rule.ids></links><search><creatorcontrib>Sun, Ning</creatorcontrib><creatorcontrib>Ren, Yumei</creatorcontrib><creatorcontrib>Wang, Mingyu</creatorcontrib><creatorcontrib>Miao, Xinyan</creatorcontrib><creatorcontrib>Meng, Zhiyong</creatorcontrib><creatorcontrib>Wang, Chaobo</creatorcontrib><creatorcontrib>Yuan, Xiaolong</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Fu, Chen</creatorcontrib><creatorcontrib>Zhang, Weiguang</creatorcontrib><creatorcontrib>Zhang, Donghan</creatorcontrib><creatorcontrib>Cheng, Ran</creatorcontrib><creatorcontrib>Wang, Pengyu</creatorcontrib><creatorcontrib>Yang, Hao</creatorcontrib><creatorcontrib>Qi, Binbin</creatorcontrib><creatorcontrib>Li, Yuzhu</creatorcontrib><creatorcontrib>Cai, Ruijuan</creatorcontrib><creatorcontrib>Li, Xiaobing</creatorcontrib><title>Gallbladder-warming Decoction with Bupleurum and Scutellaria inhibits Anxiety and Depression of Rats</title><title>IOP conference series. Earth and environmental science</title><addtitle>IOP Conf. Ser.: Earth Environ. Sci</addtitle><description>Objectives: To search the behavioral effect of Gallbladder-warming Decoction with Bupleurum and Scutellaria (GWBS) on anxiety and depression model rats and explore its mechanism. Methods: Twenty SD rats were randomly divided into four groups with 5 in each group: blank control group, model group, weastern medicine group and GWBS group. The unpredictable chronic emotional stress method was used to induce anxiety and depression of model rats. Rats in weastern medicine group were given diazepam at 0.26 mg/kg/d and the 5 rats in GWBS group were given GWBS at 11.5g/kg/d, otherwise, the other two groups were given the same volume of normal saline once a day. The experiment lasted for 10 days, during which the general state including body weight, hair color, activity level and so on were observed and the data were recorded. The results of sucrose consumption test and the light-dark box test were also recorded during the ten days. After the experiment, the changes of histological pathologic in the hippocampus were examined, and the γ-aminobutyric acid concentration of the rat hippocampus was detected using ELISA kit. Results: Pathological results indicated that GWBS improved pyramidal cells in hippocampus keeping the disordered arrangement. In comparison of the model group, the body weights of the weastern medicine group and the GWBS group apparently increased. Besides, the retention time of the light box was significantly prolonged and the concentrations of γ-aminobutyric acid in the hippocampus were significantly promoted in the two groups. The differences above were with statistical significance (P<0.05). In addition, the sucrose consumption values were improved markedly. Conclusion: GWBS, the agent of relieving the depressed liver and resolving phlegm, makes a difference in treatment of anxiety and depression rats and its mechanism may be related to the increase of GABA concentration in hippocampus.</description><subject>Anxiety</subject><subject>Benzodiazepines</subject><subject>Body weight</subject><subject>Bupleurum</subject><subject>Consumption</subject><subject>Diazepam</subject><subject>Gallbladder</subject><subject>Hippocampus</subject><subject>Lightboxes</subject><subject>Medicine</subject><subject>Mental depression</subject><subject>Pyramidal cells</subject><subject>Reagents</subject><subject>Retention time</subject><subject>Scutellaria</subject><subject>Sucrose</subject><subject>γ-Aminobutyric acid</subject><issn>1755-1307</issn><issn>1755-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkNFKwzAUhoMoOKevIAFvvKlN0qRNLuc2pyAITq9DliYuo2tr0jL39rZWJoLgVQ7k-_9z-AC4xOgGI85jnDEW4QSzmFIUkxgRgkR2BEaHj-PDjLJTcBbCBqE0o4kYgXyhimJVqDw3Ptopv3XlG5wZXenGVSXcuWYNb9u6MK1vt1CVOVzqtjFFobxT0JVrt3JNgJPyw5lm_wXMTO1NCH28svBZNeEcnFhVBHPx_Y7B6938ZXofPT4tHqaTx0hTlDURTygV_Y08t5aQVBktOBWaE0MShLUwNk0E13mGOVsJZFLGDNLGCkp1ylfJGFwNvbWv3lsTGrmpWl92KyVhjBGUCEI7Kh0o7asQvLGy9m6r_F5iJHujspcle3GyMyqJHIx2wesh6Kr6p3k-X_7CZJ3bDiV_oP_0fwKWNIUj</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Sun, Ning</creator><creator>Ren, Yumei</creator><creator>Wang, Mingyu</creator><creator>Miao, Xinyan</creator><creator>Meng, Zhiyong</creator><creator>Wang, Chaobo</creator><creator>Yuan, Xiaolong</creator><creator>Wang, Liang</creator><creator>Fu, Chen</creator><creator>Zhang, Weiguang</creator><creator>Zhang, Donghan</creator><creator>Cheng, Ran</creator><creator>Wang, Pengyu</creator><creator>Yang, Hao</creator><creator>Qi, Binbin</creator><creator>Li, Yuzhu</creator><creator>Cai, Ruijuan</creator><creator>Li, Xiaobing</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope></search><sort><creationdate>20200201</creationdate><title>Gallbladder-warming Decoction with Bupleurum and Scutellaria inhibits Anxiety and Depression of Rats</title><author>Sun, Ning ; Ren, Yumei ; Wang, Mingyu ; Miao, Xinyan ; Meng, Zhiyong ; Wang, Chaobo ; Yuan, Xiaolong ; Wang, Liang ; Fu, Chen ; Zhang, Weiguang ; Zhang, Donghan ; Cheng, Ran ; Wang, Pengyu ; Yang, Hao ; Qi, Binbin ; Li, Yuzhu ; Cai, Ruijuan ; Li, Xiaobing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-8344913078dff226aec9849c82e2301c9ef6398cd7185b90e655e0cef944c68b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anxiety</topic><topic>Benzodiazepines</topic><topic>Body weight</topic><topic>Bupleurum</topic><topic>Consumption</topic><topic>Diazepam</topic><topic>Gallbladder</topic><topic>Hippocampus</topic><topic>Lightboxes</topic><topic>Medicine</topic><topic>Mental depression</topic><topic>Pyramidal cells</topic><topic>Reagents</topic><topic>Retention time</topic><topic>Scutellaria</topic><topic>Sucrose</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Ning</creatorcontrib><creatorcontrib>Ren, Yumei</creatorcontrib><creatorcontrib>Wang, Mingyu</creatorcontrib><creatorcontrib>Miao, Xinyan</creatorcontrib><creatorcontrib>Meng, Zhiyong</creatorcontrib><creatorcontrib>Wang, Chaobo</creatorcontrib><creatorcontrib>Yuan, Xiaolong</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Fu, Chen</creatorcontrib><creatorcontrib>Zhang, Weiguang</creatorcontrib><creatorcontrib>Zhang, Donghan</creatorcontrib><creatorcontrib>Cheng, Ran</creatorcontrib><creatorcontrib>Wang, Pengyu</creatorcontrib><creatorcontrib>Yang, Hao</creatorcontrib><creatorcontrib>Qi, Binbin</creatorcontrib><creatorcontrib>Li, Yuzhu</creatorcontrib><creatorcontrib>Cai, Ruijuan</creatorcontrib><creatorcontrib>Li, Xiaobing</creatorcontrib><collection>IOP Publishing Free Content</collection><collection>IOPscience (Open Access)</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><jtitle>IOP conference series. Earth and environmental science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Ning</au><au>Ren, Yumei</au><au>Wang, Mingyu</au><au>Miao, Xinyan</au><au>Meng, Zhiyong</au><au>Wang, Chaobo</au><au>Yuan, Xiaolong</au><au>Wang, Liang</au><au>Fu, Chen</au><au>Zhang, Weiguang</au><au>Zhang, Donghan</au><au>Cheng, Ran</au><au>Wang, Pengyu</au><au>Yang, Hao</au><au>Qi, Binbin</au><au>Li, Yuzhu</au><au>Cai, Ruijuan</au><au>Li, Xiaobing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallbladder-warming Decoction with Bupleurum and Scutellaria inhibits Anxiety and Depression of Rats</atitle><jtitle>IOP conference series. Earth and environmental science</jtitle><addtitle>IOP Conf. Ser.: Earth Environ. Sci</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>440</volume><issue>2</issue><spage>22097</spage><pages>22097-</pages><issn>1755-1307</issn><eissn>1755-1315</eissn><abstract>Objectives: To search the behavioral effect of Gallbladder-warming Decoction with Bupleurum and Scutellaria (GWBS) on anxiety and depression model rats and explore its mechanism. Methods: Twenty SD rats were randomly divided into four groups with 5 in each group: blank control group, model group, weastern medicine group and GWBS group. The unpredictable chronic emotional stress method was used to induce anxiety and depression of model rats. Rats in weastern medicine group were given diazepam at 0.26 mg/kg/d and the 5 rats in GWBS group were given GWBS at 11.5g/kg/d, otherwise, the other two groups were given the same volume of normal saline once a day. The experiment lasted for 10 days, during which the general state including body weight, hair color, activity level and so on were observed and the data were recorded. The results of sucrose consumption test and the light-dark box test were also recorded during the ten days. After the experiment, the changes of histological pathologic in the hippocampus were examined, and the γ-aminobutyric acid concentration of the rat hippocampus was detected using ELISA kit. Results: Pathological results indicated that GWBS improved pyramidal cells in hippocampus keeping the disordered arrangement. In comparison of the model group, the body weights of the weastern medicine group and the GWBS group apparently increased. Besides, the retention time of the light box was significantly prolonged and the concentrations of γ-aminobutyric acid in the hippocampus were significantly promoted in the two groups. The differences above were with statistical significance (P<0.05). In addition, the sucrose consumption values were improved markedly. Conclusion: GWBS, the agent of relieving the depressed liver and resolving phlegm, makes a difference in treatment of anxiety and depression rats and its mechanism may be related to the increase of GABA concentration in hippocampus.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1755-1315/440/2/022097</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anxiety Benzodiazepines Body weight Bupleurum Consumption Diazepam Gallbladder Hippocampus Lightboxes Medicine Mental depression Pyramidal cells Reagents Retention time Scutellaria Sucrose γ-Aminobutyric acid |
| title | Gallbladder-warming Decoction with Bupleurum and Scutellaria inhibits Anxiety and Depression of Rats |
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