Matlodextrin-cinnamon essential oil nanoformulation as a potent protective against titanium nanoparticles-induced oxidative stress, genotoxicity, and reproductive disturbances in male mice
Recently, bio-nanofabrication becomes one of the widest methods for synthesizing nanoparticles (NPs); however, there is scanty literature exploring the toxicity of these green NPs against living organisms. This study aimed to evaluate the potential protective role of encapsulated cinnamon oil (ECO)...
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| creator | Salman, Asmaa S. Al-Shaikh, Turki M. Hamza, Zeinab K. El-Nekeety, Aziza A. Bawazir, Salwa S. Hassan, Nabila S. Abdel-Wahhab, Mosaad A. |
| description | Recently, bio-nanofabrication becomes one of the widest methods for synthesizing nanoparticles (NPs); however, there is scanty literature exploring the toxicity of these green NPs against living organisms. This study aimed to evaluate the potential protective role of encapsulated cinnamon oil (ECO) against titanium oxide nanoparticle (TiO
2
NP)–induced oxidative stress, DNA damage, chromosomal aberration, and reproductive disturbances in male mice. Sixty male Balb/c mice were distributed into six groups treated orally for 3 weeks and included control group, TiO
2
NP-treated group (25 mg/kg b.w), ECO at low or high dose–treated groups (50 or 100 mg/kg b.w), and the groups that received TiO
2
NPs plus ECO at a low or high dose. The results of GC-MS revealed the isolation of 21 compounds and the majority was cinnamaldehyde. The average size zeta potential of TiO
2
NPs and ECO were 28.9 and 321 nm and −33.97 and −17.35 mV, respectively. TiO
2
NP administration induced significant changes in liver and kidney function, decreased antioxidant capacity, and increased oxidative stress markers in liver and kidney, DNA damage in the hepatocytes, the number of chromosomal aberrations in the bone marrow and germ cells, and sperm abnormalities along with histological changes in the liver, kidney, and testis. Co-administration of TiO
2
NPs and ECO could alleviate these disturbances in a dose-dependent manner. It could be concluded that ECO is a promising and safe candidate for the protection against the health hazards of TiO
2
NPs. |
| doi_str_mv | 10.1007/s11356-021-13518-0 |
| format | Article |
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2
NP)–induced oxidative stress, DNA damage, chromosomal aberration, and reproductive disturbances in male mice. Sixty male Balb/c mice were distributed into six groups treated orally for 3 weeks and included control group, TiO
2
NP-treated group (25 mg/kg b.w), ECO at low or high dose–treated groups (50 or 100 mg/kg b.w), and the groups that received TiO
2
NPs plus ECO at a low or high dose. The results of GC-MS revealed the isolation of 21 compounds and the majority was cinnamaldehyde. The average size zeta potential of TiO
2
NPs and ECO were 28.9 and 321 nm and −33.97 and −17.35 mV, respectively. TiO
2
NP administration induced significant changes in liver and kidney function, decreased antioxidant capacity, and increased oxidative stress markers in liver and kidney, DNA damage in the hepatocytes, the number of chromosomal aberrations in the bone marrow and germ cells, and sperm abnormalities along with histological changes in the liver, kidney, and testis. Co-administration of TiO
2
NPs and ECO could alleviate these disturbances in a dose-dependent manner. It could be concluded that ECO is a promising and safe candidate for the protection against the health hazards of TiO
2
NPs.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-021-13518-0</identifier><identifier>PMID: 33745051</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abnormalities ; Animals ; Antioxidants ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bone marrow ; Chromosome aberrations ; Cinnamaldehyde ; Cinnamomum zeylanicum ; Cinnamon ; Damage ; Deoxyribonucleic acid ; Disturbances ; DNA ; DNA Damage ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Essential oils ; Genotoxicity ; Germ cells ; Health hazards ; Hepatocytes ; Kidneys ; Liver ; Male ; Males ; Mice ; Nanofabrication ; Nanoparticles ; Oils, Volatile ; Oxidative Stress ; Research Article ; Titanium ; Titanium - toxicity ; Titanium oxide ; Titanium oxides ; Toxicity ; Waste Water Technology ; Water Management ; Water Pollution Control ; Zeta potential</subject><ispartof>Environmental science and pollution research international, 2021-08, Vol.28 (29), p.39035-39051</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ab7f195a97343e1abb443ebbd6a2e5078cd3e34f6f4e9357aa708574bbecf4d23</citedby><cites>FETCH-LOGICAL-c375t-ab7f195a97343e1abb443ebbd6a2e5078cd3e34f6f4e9357aa708574bbecf4d23</cites><orcidid>0000-0002-7174-3341</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-021-13518-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-021-13518-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33745051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salman, Asmaa S.</creatorcontrib><creatorcontrib>Al-Shaikh, Turki M.</creatorcontrib><creatorcontrib>Hamza, Zeinab K.</creatorcontrib><creatorcontrib>El-Nekeety, Aziza A.</creatorcontrib><creatorcontrib>Bawazir, Salwa S.</creatorcontrib><creatorcontrib>Hassan, Nabila S.</creatorcontrib><creatorcontrib>Abdel-Wahhab, Mosaad A.</creatorcontrib><title>Matlodextrin-cinnamon essential oil nanoformulation as a potent protective against titanium nanoparticles-induced oxidative stress, genotoxicity, and reproductive disturbances in male mice</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Recently, bio-nanofabrication becomes one of the widest methods for synthesizing nanoparticles (NPs); however, there is scanty literature exploring the toxicity of these green NPs against living organisms. This study aimed to evaluate the potential protective role of encapsulated cinnamon oil (ECO) against titanium oxide nanoparticle (TiO
2
NP)–induced oxidative stress, DNA damage, chromosomal aberration, and reproductive disturbances in male mice. Sixty male Balb/c mice were distributed into six groups treated orally for 3 weeks and included control group, TiO
2
NP-treated group (25 mg/kg b.w), ECO at low or high dose–treated groups (50 or 100 mg/kg b.w), and the groups that received TiO
2
NPs plus ECO at a low or high dose. The results of GC-MS revealed the isolation of 21 compounds and the majority was cinnamaldehyde. The average size zeta potential of TiO
2
NPs and ECO were 28.9 and 321 nm and −33.97 and −17.35 mV, respectively. TiO
2
NP administration induced significant changes in liver and kidney function, decreased antioxidant capacity, and increased oxidative stress markers in liver and kidney, DNA damage in the hepatocytes, the number of chromosomal aberrations in the bone marrow and germ cells, and sperm abnormalities along with histological changes in the liver, kidney, and testis. Co-administration of TiO
2
NPs and ECO could alleviate these disturbances in a dose-dependent manner. It could be concluded that ECO is a promising and safe candidate for the protection against the health hazards of TiO
2
NPs.</description><subject>Abnormalities</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bone marrow</subject><subject>Chromosome aberrations</subject><subject>Cinnamaldehyde</subject><subject>Cinnamomum zeylanicum</subject><subject>Cinnamon</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>Disturbances</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Essential oils</subject><subject>Genotoxicity</subject><subject>Germ cells</subject><subject>Health 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essential oil nanoformulation as a potent protective against titanium nanoparticles-induced oxidative stress, genotoxicity, and reproductive disturbances in male mice</title><author>Salman, Asmaa S. ; Al-Shaikh, Turki M. ; Hamza, Zeinab K. ; El-Nekeety, Aziza A. ; Bawazir, Salwa S. ; Hassan, Nabila S. ; Abdel-Wahhab, Mosaad A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ab7f195a97343e1abb443ebbd6a2e5078cd3e34f6f4e9357aa708574bbecf4d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abnormalities</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bone marrow</topic><topic>Chromosome aberrations</topic><topic>Cinnamaldehyde</topic><topic>Cinnamomum zeylanicum</topic><topic>Cinnamon</topic><topic>Damage</topic><topic>Deoxyribonucleic 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salman, Asmaa S.</au><au>Al-Shaikh, Turki M.</au><au>Hamza, Zeinab K.</au><au>El-Nekeety, Aziza A.</au><au>Bawazir, Salwa S.</au><au>Hassan, Nabila S.</au><au>Abdel-Wahhab, Mosaad A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matlodextrin-cinnamon essential oil nanoformulation as a potent protective against titanium nanoparticles-induced oxidative stress, genotoxicity, and reproductive disturbances in male mice</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>28</volume><issue>29</issue><spage>39035</spage><epage>39051</epage><pages>39035-39051</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Recently, bio-nanofabrication becomes one of the widest methods for synthesizing nanoparticles (NPs); however, there is scanty literature exploring the toxicity of these green NPs against living organisms. This study aimed to evaluate the potential protective role of encapsulated cinnamon oil (ECO) against titanium oxide nanoparticle (TiO
2
NP)–induced oxidative stress, DNA damage, chromosomal aberration, and reproductive disturbances in male mice. Sixty male Balb/c mice were distributed into six groups treated orally for 3 weeks and included control group, TiO
2
NP-treated group (25 mg/kg b.w), ECO at low or high dose–treated groups (50 or 100 mg/kg b.w), and the groups that received TiO
2
NPs plus ECO at a low or high dose. The results of GC-MS revealed the isolation of 21 compounds and the majority was cinnamaldehyde. The average size zeta potential of TiO
2
NPs and ECO were 28.9 and 321 nm and −33.97 and −17.35 mV, respectively. TiO
2
NP administration induced significant changes in liver and kidney function, decreased antioxidant capacity, and increased oxidative stress markers in liver and kidney, DNA damage in the hepatocytes, the number of chromosomal aberrations in the bone marrow and germ cells, and sperm abnormalities along with histological changes in the liver, kidney, and testis. Co-administration of TiO
2
NPs and ECO could alleviate these disturbances in a dose-dependent manner. It could be concluded that ECO is a promising and safe candidate for the protection against the health hazards of TiO
2
NPs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33745051</pmid><doi>10.1007/s11356-021-13518-0</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-7174-3341</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2021-08, Vol.28 (29), p.39035-39051 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Abnormalities Animals Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bone marrow Chromosome aberrations Cinnamaldehyde Cinnamomum zeylanicum Cinnamon Damage Deoxyribonucleic acid Disturbances DNA DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Essential oils Genotoxicity Germ cells Health hazards Hepatocytes Kidneys Liver Male Males Mice Nanofabrication Nanoparticles Oils, Volatile Oxidative Stress Research Article Titanium Titanium - toxicity Titanium oxide Titanium oxides Toxicity Waste Water Technology Water Management Water Pollution Control Zeta potential |
| title | Matlodextrin-cinnamon essential oil nanoformulation as a potent protective against titanium nanoparticles-induced oxidative stress, genotoxicity, and reproductive disturbances in male mice |
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