Analysis of a Set of KDM5C Regulatory Genes Mutated in Neurodevelopmental Disorders Identifies Temporal Coexpression Brain Signatures

Dysregulation of transcriptional pathways is observed in multiple forms of neurodevelopmental disorders (NDDs), such as intellectual disability (ID), epilepsy and autism spectrum disorder (ASD). We previously demonstrated that the NDD genes encoding lysine-specific demethylase 5C ( ) and its transcr...

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Veröffentlicht in:	Genes 2021-07, Vol.12 (7), p.1088
Hauptverfasser:	Poeta, Loredana, Padula, Agnese, Lioi, Maria Brigida, van Bokhoven, Hans, Miano, Maria Giuseppina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animals Antibodies Autism Autism Spectrum Disorder - genetics Binding sites Biotechnology Brain Cell Line, Tumor DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenetics Epilepsy Epilepsy - genetics Gene expression Gene Expression - genetics Gene Expression Regulation - genetics Genes, Homeobox - genetics Genes, X-Linked Histone Demethylases - genetics Histone Demethylases - metabolism Histones Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunoprecipitation Intellectual disabilities Intellectual Disability - genetics Lymphoblastoid cell lines Lysine Methylation Mice Microcephaly Mutation Neurodevelopmental disorders Neurodevelopmental Disorders - genetics Proteins Software Synteny Transcription Factors - genetics Transcription Factors - metabolism Transcriptome - genetics Zinc finger proteins
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