Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer

Background and Aims Mutational signature analyses are an effective tool in identifying cancer etiology. Humans are frequently exposed to pyrrolizidine alkaloids (PAs), the most common carcinogenic phytotoxins widely distributed in herbal remedies and foods. However, due to the lack of human epidemio...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2021-07, Vol.74 (1), p.264-280
Hauptverfasser:	He, Yisheng, Shi, Mai, Wu, Xu, Ma, Jiang, Ng, Kevin Tak‐Pan, Xia, Qingsu, Zhu, Lin, Fu, Peter Pi‐Cheng, Man, Kwan, Tsui, Stephen Kwok‐Wing, Lin, Ge
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Animals Biomarkers Carcinogenesis - chemically induced Carcinogenesis - genetics Cell Line, Tumor Deoxyribonucleic acid DNA DNA adducts DNA damage DNA Damage - drug effects DNA Mutational Analysis Epidemiology Etiology Female Genomes Hepatocytes Hepatology Herbal medicine Humans Liver - drug effects Liver - pathology Liver cancer Liver Neoplasms - chemically induced Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - pathology Male Mice Mutation Patients Phytotoxins Progenitor cells Protein adducts Pyrrolizidine alkaloids Pyrrolizidine Alkaloids - adverse effects Retrorsine Stem cells Whole Exome Sequencing
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