5-Aza-2-deoxycytidine alleviates the progression of primary biliary cholangitis by suppressing the FoxP3 methylation and promoting the Treg/Th17 balance

•Imbalanced Treg/Th17 axis shapes hepatic inflammatory microenvironment in PBC.•FoxP3 hypermethylation happened in PBC, leading to the imbalanced Treg/Th17 axis.•Increased DNMT1 and decreased IDH1 enhance the FoxP3 methylation.•Demethylation of FoxP3 rebalances Treg/Th17 axis, inhibiting inflammatio...

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Veröffentlicht in:	International immunopharmacology 2021-07, Vol.96, p.107820, Article 107820
Hauptverfasser:	Jiang, Ting, Zhang, Hong-wei, Wen, Yan-ping, Yin, Yue-shan, Yang, Li-hong, Yang, Jing, Lan, Tian, Tang, Cheng-wei, Yu, Jian-kun, Tai, Wen-lin, Yang, Jin-hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use CD4 antigen Cholangitis Decitabine - pharmacology Decitabine - therapeutic use Demethylation Deoxyribonucleic acid Dioxygenases - genetics DNA DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA methylation DNA Methylation - drug effects DNA methyltransferase DNA-Binding Proteins - genetics Epithelial cells Epithelium Female Forkhead box protein 3 Forkhead Transcription Factors - genetics Foxp3 protein Helper cells Humans Immunological tolerance Immunology Inflammation Isocitrate Dehydrogenase - genetics Liver Liver - metabolism Liver Cirrhosis, Biliary - drug therapy Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - immunology Liver diseases Lymphocytes Lymphocytes T Male Methylation Mice Mice, Inbred C57BL Microenvironments Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Primary biliary cholangitis Regulatory mechanisms (biology) Regulatory T cells T helper 17 cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th17 Cells - drug effects Th17 Cells - immunology Transcription
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