ANTIOXIDANT PHENOLIC COMPOUNDS FROM MOLASSES OF LAUROCERASUS OFFICINALIS ROEM. (CHERRY LAUREL) AMELIORATE CARBON TETRACHLORIDE (CCL4)-INDUCED LIVER INJURY IN RATS
The fruits of Laurocerasus officinalis (cherry laurel) and products made from this are used for many years against several illnesses in Turkish folk medicine. The objective of this study was to investigate the phenolic composition, in vitro antioxidant properties of cherry laurel molasses, and also...
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| Veröffentlicht in: | Fresenius environmental bulletin 2021-06, Vol.30 (6B), p.7780 |
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| description | The fruits of Laurocerasus officinalis (cherry laurel) and products made from this are used for many years against several illnesses in Turkish folk medicine. The objective of this study was to investigate the phenolic composition, in vitro antioxidant properties of cherry laurel molasses, and also hepa-toprotective mechanisms in carbon tetrachloride (CCl4)-induced hepatotoxicity in vivo. In this study, total phenolic and flavonoid content, and antioxidant capacity of cherry laurel molasses was determined by in vitro assessments. Effects on liver hepatoxicity were investigated using the CCl4-induced toxicity rat model. The results reveal that molasses contained in high amounts of total polyphenols and, total flavonoids. The in vivo observations showed that cherry laurel molasses treatment significantly decreased lipid peroxidation, NOx levels in the liver, and serum transaminases. Also, molasses treatment was significantly increased superoxide dismutasc and catalasc activity and glutathione level in the liver. Histo-pathological determination confirmed that treatment of molasses prevented hepatocellular damage and inflammation in CCl4-administered group. In conclusion, cherry laurel molasses accomplished hepato-protective effects by improving hepatic antioxidant status and preventing hepatocellular damage. |
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(CHERRY LAUREL) AMELIORATE CARBON TETRACHLORIDE (CCL4)-INDUCED LIVER INJURY IN RATS</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Peker, Emine Gulceri Gulec</creator><creatorcontrib>Peker, Emine Gulceri Gulec</creatorcontrib><description>The fruits of Laurocerasus officinalis (cherry laurel) and products made from this are used for many years against several illnesses in Turkish folk medicine. The objective of this study was to investigate the phenolic composition, in vitro antioxidant properties of cherry laurel molasses, and also hepa-toprotective mechanisms in carbon tetrachloride (CCl4)-induced hepatotoxicity in vivo. In this study, total phenolic and flavonoid content, and antioxidant capacity of cherry laurel molasses was determined by in vitro assessments. Effects on liver hepatoxicity were investigated using the CCl4-induced toxicity rat model. The results reveal that molasses contained in high amounts of total polyphenols and, total flavonoids. The in vivo observations showed that cherry laurel molasses treatment significantly decreased lipid peroxidation, NOx levels in the liver, and serum transaminases. Also, molasses treatment was significantly increased superoxide dismutasc and catalasc activity and glutathione level in the liver. Histo-pathological determination confirmed that treatment of molasses prevented hepatocellular damage and inflammation in CCl4-administered group. In conclusion, cherry laurel molasses accomplished hepato-protective effects by improving hepatic antioxidant status and preventing hepatocellular damage.</description><identifier>ISSN: 1018-4619</identifier><identifier>EISSN: 1610-2304</identifier><language>eng</language><publisher>Freising: Parlar Scientific Publications</publisher><subject>Antioxidants ; Biocompatibility ; Carbon ; Carbon tetrachloride ; CCL4 protein ; Damage prevention ; Flavonoids ; Fruits ; Glutathione ; Hepatotoxicity ; In vivo methods and tests ; Lipid peroxidation ; Lipids ; Liver ; Molasses ; Peroxidation ; Phenolic compounds ; Phenols ; Polyphenols ; Prunus laurocerasus ; Syrups & sweeteners ; Toxicity</subject><ispartof>Fresenius environmental bulletin, 2021-06, Vol.30 (6B), p.7780</ispartof><rights>Copyright Parlar Scientific Publications Jun 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Peker, Emine Gulceri Gulec</creatorcontrib><title>ANTIOXIDANT PHENOLIC COMPOUNDS FROM MOLASSES OF LAUROCERASUS OFFICINALIS ROEM. (CHERRY LAUREL) AMELIORATE CARBON TETRACHLORIDE (CCL4)-INDUCED LIVER INJURY IN RATS</title><title>Fresenius environmental bulletin</title><description>The fruits of Laurocerasus officinalis (cherry laurel) and products made from this are used for many years against several illnesses in Turkish folk medicine. The objective of this study was to investigate the phenolic composition, in vitro antioxidant properties of cherry laurel molasses, and also hepa-toprotective mechanisms in carbon tetrachloride (CCl4)-induced hepatotoxicity in vivo. In this study, total phenolic and flavonoid content, and antioxidant capacity of cherry laurel molasses was determined by in vitro assessments. Effects on liver hepatoxicity were investigated using the CCl4-induced toxicity rat model. The results reveal that molasses contained in high amounts of total polyphenols and, total flavonoids. The in vivo observations showed that cherry laurel molasses treatment significantly decreased lipid peroxidation, NOx levels in the liver, and serum transaminases. Also, molasses treatment was significantly increased superoxide dismutasc and catalasc activity and glutathione level in the liver. Histo-pathological determination confirmed that treatment of molasses prevented hepatocellular damage and inflammation in CCl4-administered group. In conclusion, cherry laurel molasses accomplished hepato-protective effects by improving hepatic antioxidant status and preventing hepatocellular damage.</description><subject>Antioxidants</subject><subject>Biocompatibility</subject><subject>Carbon</subject><subject>Carbon tetrachloride</subject><subject>CCL4 protein</subject><subject>Damage prevention</subject><subject>Flavonoids</subject><subject>Fruits</subject><subject>Glutathione</subject><subject>Hepatotoxicity</subject><subject>In vivo methods and tests</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Molasses</subject><subject>Peroxidation</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Polyphenols</subject><subject>Prunus laurocerasus</subject><subject>Syrups & sweeteners</subject><subject>Toxicity</subject><issn>1018-4619</issn><issn>1610-2304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNotTUlOwzAAjBBIVKV_sMSFHoK8xI5zNI5DjBy7chIEpyqtw6FCtDTth3gpZpnLzEizXCQzxBBMMYHZZdQQ8TRjqLhOFtO0gxEM55iRWfIlbKfdiy4jg1WtrDNaAumalett2YLKuwY0zoi2VS1wFTCi904qL9r-x1daaiuMboF3qrkHd7JW3r_-xpRZAtEoo50XnQJS-AdnQac6L2RtnNelinlpsmWqbdlLVQKjn5UH2j71cUNbEIvtTXL1NrxP4-Kf50lfqU7WqXGPWgqTHhAip3QTMhoGOHLKWTEyHsZtkRVouxkpDAEFyDnOtwUfMM5DyCkJcJMTPA4EEZbDjMyT27_dw3H_eR6n03q3Px8_4uUaU0ooo5gi8g3FVlrB</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Peker, Emine Gulceri Gulec</creator><general>Parlar Scientific Publications</general><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>20210601</creationdate><title>ANTIOXIDANT PHENOLIC COMPOUNDS FROM MOLASSES OF LAUROCERASUS OFFICINALIS ROEM. (CHERRY LAUREL) AMELIORATE CARBON TETRACHLORIDE (CCL4)-INDUCED LIVER INJURY IN RATS</title><author>Peker, Emine Gulceri Gulec</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p113t-bd45da0e85869e68dec9491cbe50dd1d08827c98a227dd753d0b732ea31367043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Biocompatibility</topic><topic>Carbon</topic><topic>Carbon tetrachloride</topic><topic>CCL4 protein</topic><topic>Damage prevention</topic><topic>Flavonoids</topic><topic>Fruits</topic><topic>Glutathione</topic><topic>Hepatotoxicity</topic><topic>In vivo methods and tests</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver</topic><topic>Molasses</topic><topic>Peroxidation</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Polyphenols</topic><topic>Prunus laurocerasus</topic><topic>Syrups & sweeteners</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peker, Emine Gulceri Gulec</creatorcontrib><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Fresenius environmental bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peker, Emine Gulceri Gulec</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANTIOXIDANT PHENOLIC COMPOUNDS FROM MOLASSES OF LAUROCERASUS OFFICINALIS ROEM. (CHERRY LAUREL) AMELIORATE CARBON TETRACHLORIDE (CCL4)-INDUCED LIVER INJURY IN RATS</atitle><jtitle>Fresenius environmental bulletin</jtitle><date>2021-06-01</date><risdate>2021</risdate><volume>30</volume><issue>6B</issue><spage>7780</spage><pages>7780-</pages><issn>1018-4619</issn><eissn>1610-2304</eissn><abstract>The fruits of Laurocerasus officinalis (cherry laurel) and products made from this are used for many years against several illnesses in Turkish folk medicine. The objective of this study was to investigate the phenolic composition, in vitro antioxidant properties of cherry laurel molasses, and also hepa-toprotective mechanisms in carbon tetrachloride (CCl4)-induced hepatotoxicity in vivo. In this study, total phenolic and flavonoid content, and antioxidant capacity of cherry laurel molasses was determined by in vitro assessments. Effects on liver hepatoxicity were investigated using the CCl4-induced toxicity rat model. The results reveal that molasses contained in high amounts of total polyphenols and, total flavonoids. The in vivo observations showed that cherry laurel molasses treatment significantly decreased lipid peroxidation, NOx levels in the liver, and serum transaminases. Also, molasses treatment was significantly increased superoxide dismutasc and catalasc activity and glutathione level in the liver. Histo-pathological determination confirmed that treatment of molasses prevented hepatocellular damage and inflammation in CCl4-administered group. In conclusion, cherry laurel molasses accomplished hepato-protective effects by improving hepatic antioxidant status and preventing hepatocellular damage.</abstract><cop>Freising</cop><pub>Parlar Scientific Publications</pub></addata></record> |
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| ispartof | Fresenius environmental bulletin, 2021-06, Vol.30 (6B), p.7780 |
| issn | 1018-4619 1610-2304 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Antioxidants Biocompatibility Carbon Carbon tetrachloride CCL4 protein Damage prevention Flavonoids Fruits Glutathione Hepatotoxicity In vivo methods and tests Lipid peroxidation Lipids Liver Molasses Peroxidation Phenolic compounds Phenols Polyphenols Prunus laurocerasus Syrups & sweeteners Toxicity |
| title | ANTIOXIDANT PHENOLIC COMPOUNDS FROM MOLASSES OF LAUROCERASUS OFFICINALIS ROEM. (CHERRY LAUREL) AMELIORATE CARBON TETRACHLORIDE (CCL4)-INDUCED LIVER INJURY IN RATS |
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