Association of circulating leptin and adiponectin levels with colorectal cancer risk: A systematic review and meta-analysis of case-control studies
•The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk.•Subgroup analysis revealed that a higher level of adiponectin was associated with an increased CRC risk among overweight individuals.•Subgroup analysis revealed that a highe...
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| Veröffentlicht in: | Cancer epidemiology 2021-08, Vol.73, p.101958, Article 101958 |
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| container_title | Cancer epidemiology |
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| creator | Wang, Yan Li, Junyong Fu, Xiaolin Li, Jialing Liu, Lihua Alkohlani, Albatoul Tan, Shing Cheng Low, Teck Yew Hou, Yue |
| description | •The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk.•Subgroup analysis revealed that a higher level of adiponectin was associated with an increased CRC risk among overweight individuals.•Subgroup analysis revealed that a higher level of adiponectin was associated with a decreased CRC risk among normal weight individuals.
Leptin and adiponectin are adipokines which have been commonly implicated in carcinogenesis. As such, many studies have investigated the association of circulating leptin and adiponectin levels with colorectal cancer (CRC) risk. However, the results remained inconsistent.
In this work, we performed a systematic review and meta-analysis to precisely examine the association between circulating levels of leptin and adiponectin and CRC risk. A systematic literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and EMBASE databases from inception until October 2020. The pooled effect size was then estimated by calculating the odds ratio (OR).
A total of 23 records (comprising 26 studies) were included in the meta-analysis. The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk (P > 0.05). Interestingly, subgroup analysis revealed that a higher level of adiponectin was significantly associated with an increased CRC risk among overweight individuals (OR = 1.16; 95 % CI: 1.02, 1.32), and a decreased CRC risk among normal weight individuals (OR = 0.76; 95 % CI: 0.62, 0.92). Besides, a higher level of adiponectin was also significantly associated with a decreased risk of CRC in men (OR = 0.76; 95 % CI: 0.59, 0.98).
In conclusion, circulating leptin level was not associated with CRC risk, but that of adiponectin was associated with CRC risk only in specific subgroups. |
| doi_str_mv | 10.1016/j.canep.2021.101958 |
| format | Article |
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Leptin and adiponectin are adipokines which have been commonly implicated in carcinogenesis. As such, many studies have investigated the association of circulating leptin and adiponectin levels with colorectal cancer (CRC) risk. However, the results remained inconsistent.
In this work, we performed a systematic review and meta-analysis to precisely examine the association between circulating levels of leptin and adiponectin and CRC risk. A systematic literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and EMBASE databases from inception until October 2020. The pooled effect size was then estimated by calculating the odds ratio (OR).
A total of 23 records (comprising 26 studies) were included in the meta-analysis. The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk (P > 0.05). Interestingly, subgroup analysis revealed that a higher level of adiponectin was significantly associated with an increased CRC risk among overweight individuals (OR = 1.16; 95 % CI: 1.02, 1.32), and a decreased CRC risk among normal weight individuals (OR = 0.76; 95 % CI: 0.62, 0.92). Besides, a higher level of adiponectin was also significantly associated with a decreased risk of CRC in men (OR = 0.76; 95 % CI: 0.59, 0.98).
In conclusion, circulating leptin level was not associated with CRC risk, but that of adiponectin was associated with CRC risk only in specific subgroups.</description><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2021.101958</identifier><language>eng</language><publisher>New York: Elsevier Ltd</publisher><subject>Adiponectin ; Bias ; Biomarkers ; Body mass index ; Body weight ; Cancer ; Carcinogenesis ; Carcinogens ; Cell growth ; Colorectal ; Colorectal cancer ; Colorectal carcinoma ; Epidemiology ; Health risks ; Hormones ; Insulin resistance ; Leptin ; Meta-analysis ; Obesity ; Overweight ; Peptides ; Risk ; Subgroups ; Systematic review ; Tumor necrosis factor-TNF ; Tumors</subject><ispartof>Cancer epidemiology, 2021-08, Vol.73, p.101958, Article 101958</ispartof><rights>2021 Elsevier Ltd</rights><rights>2021. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-3937b2bbf918f883a8c84921a03d5aa8d761b8b65e82305071313afc2278ede23</citedby><cites>FETCH-LOGICAL-c364t-3937b2bbf918f883a8c84921a03d5aa8d761b8b65e82305071313afc2278ede23</cites><orcidid>0000-0001-7878-7534</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2553516249?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974,64362,64366,72216</link.rule.ids></links><search><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Li, Junyong</creatorcontrib><creatorcontrib>Fu, Xiaolin</creatorcontrib><creatorcontrib>Li, Jialing</creatorcontrib><creatorcontrib>Liu, Lihua</creatorcontrib><creatorcontrib>Alkohlani, Albatoul</creatorcontrib><creatorcontrib>Tan, Shing Cheng</creatorcontrib><creatorcontrib>Low, Teck Yew</creatorcontrib><creatorcontrib>Hou, Yue</creatorcontrib><title>Association of circulating leptin and adiponectin levels with colorectal cancer risk: A systematic review and meta-analysis of case-control studies</title><title>Cancer epidemiology</title><description>•The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk.•Subgroup analysis revealed that a higher level of adiponectin was associated with an increased CRC risk among overweight individuals.•Subgroup analysis revealed that a higher level of adiponectin was associated with a decreased CRC risk among normal weight individuals.
Leptin and adiponectin are adipokines which have been commonly implicated in carcinogenesis. As such, many studies have investigated the association of circulating leptin and adiponectin levels with colorectal cancer (CRC) risk. However, the results remained inconsistent.
In this work, we performed a systematic review and meta-analysis to precisely examine the association between circulating levels of leptin and adiponectin and CRC risk. A systematic literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and EMBASE databases from inception until October 2020. The pooled effect size was then estimated by calculating the odds ratio (OR).
A total of 23 records (comprising 26 studies) were included in the meta-analysis. The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk (P > 0.05). Interestingly, subgroup analysis revealed that a higher level of adiponectin was significantly associated with an increased CRC risk among overweight individuals (OR = 1.16; 95 % CI: 1.02, 1.32), and a decreased CRC risk among normal weight individuals (OR = 0.76; 95 % CI: 0.62, 0.92). Besides, a higher level of adiponectin was also significantly associated with a decreased risk of CRC in men (OR = 0.76; 95 % CI: 0.59, 0.98).
In conclusion, circulating leptin level was not associated with CRC risk, but that of adiponectin was associated with CRC risk only in specific subgroups.</description><subject>Adiponectin</subject><subject>Bias</subject><subject>Biomarkers</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cell growth</subject><subject>Colorectal</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Epidemiology</subject><subject>Health risks</subject><subject>Hormones</subject><subject>Insulin resistance</subject><subject>Leptin</subject><subject>Meta-analysis</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Peptides</subject><subject>Risk</subject><subject>Subgroups</subject><subject>Systematic review</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><issn>1877-7821</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMtOwzAQRSMEEqXwBWwssU7xo0kcJBZVxUuqxAYkdpbjTMDFjYMnbdXv4IdxWsSS1Tw0987MSZJLRieMsvx6OTG6hW7CKWdDp8zkUTJisijSQoq347-cs9PkDHFJaZ4zlo2S7xmiN1b31rfEN8TYYNYulu07cdDFSHRbE13bzrdghtrBBhySre0_iPHOh9jWjsQLDAQSLH7ekBnBHfawikaGBNhY2O59VtDrVLfa7dDifp9GSI1v--AdwX5dW8Dz5KTRDuHiN46T1_u7l_ljunh-eJrPFqkR-bRPRSmKildVUzLZSCm0NHJacqapqDOtZV3krJJVnoHkgma0YIIJ3RjOCwk1cDFOrg6-XfBfa8BeLf06xONQ8SwTGcv5tIxT4jBlgkcM0Kgu2JUOO8WoGuirpdrTVwN9daAfVbcHVUQ1vB8UGguRUG0HXqr29l_9D2NDkVQ</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Wang, Yan</creator><creator>Li, Junyong</creator><creator>Fu, Xiaolin</creator><creator>Li, Jialing</creator><creator>Liu, Lihua</creator><creator>Alkohlani, Albatoul</creator><creator>Tan, Shing Cheng</creator><creator>Low, Teck Yew</creator><creator>Hou, Yue</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0001-7878-7534</orcidid></search><sort><creationdate>202108</creationdate><title>Association of circulating leptin and adiponectin levels with colorectal cancer risk: A systematic review and meta-analysis of case-control studies</title><author>Wang, Yan ; 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Leptin and adiponectin are adipokines which have been commonly implicated in carcinogenesis. As such, many studies have investigated the association of circulating leptin and adiponectin levels with colorectal cancer (CRC) risk. However, the results remained inconsistent.
In this work, we performed a systematic review and meta-analysis to precisely examine the association between circulating levels of leptin and adiponectin and CRC risk. A systematic literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and EMBASE databases from inception until October 2020. The pooled effect size was then estimated by calculating the odds ratio (OR).
A total of 23 records (comprising 26 studies) were included in the meta-analysis. The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk (P > 0.05). Interestingly, subgroup analysis revealed that a higher level of adiponectin was significantly associated with an increased CRC risk among overweight individuals (OR = 1.16; 95 % CI: 1.02, 1.32), and a decreased CRC risk among normal weight individuals (OR = 0.76; 95 % CI: 0.62, 0.92). Besides, a higher level of adiponectin was also significantly associated with a decreased risk of CRC in men (OR = 0.76; 95 % CI: 0.59, 0.98).
In conclusion, circulating leptin level was not associated with CRC risk, but that of adiponectin was associated with CRC risk only in specific subgroups.</abstract><cop>New York</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.canep.2021.101958</doi><orcidid>https://orcid.org/0000-0001-7878-7534</orcidid></addata></record> |
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| subjects | Adiponectin Bias Biomarkers Body mass index Body weight Cancer Carcinogenesis Carcinogens Cell growth Colorectal Colorectal cancer Colorectal carcinoma Epidemiology Health risks Hormones Insulin resistance Leptin Meta-analysis Obesity Overweight Peptides Risk Subgroups Systematic review Tumor necrosis factor-TNF Tumors |
| title | Association of circulating leptin and adiponectin levels with colorectal cancer risk: A systematic review and meta-analysis of case-control studies |
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