The flavodoxin FldA activates the class Ia ribonucleotide reductase of Campylobacter jejuni

Campylobacter jejuni is a microaerophilic zoonotic pathogen with an atypical respiratory Complex I that oxidizes a flavodoxin (FldA) instead of NADH. FldA is essential for viability and is reduced via pyruvate and 2‐oxoglutarate oxidoreductases (POR/OOR). Here, we show that FldA can also be reduced...

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Veröffentlicht in:	Molecular microbiology 2021-07, Vol.116 (1), p.343-358
Hauptverfasser:	Alqurashi, Abdulmajeed, Alfs, Laura, Swann, Jordan, Butt, Julea N., Kelly, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Campylobacter Campylobacter jejuni Cj0559 Deletion mutant Electron paramagnetic resonance Electron spin resonance Electron transport chain Ferredoxin flavin Flavodoxin flavodoxin reductase FqrB Life Sciences & Biomedicine Microbiology Mutants NADH Nicotinamide adenine dinucleotide Pyruvic acid Reductase Reductases Ribonucleotide reductase Science & Technology Spectroscopy tyrosyl radical
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