239 Decr2 loss promotes resistance of tumor cells to immunotherapy by affecting CD8+ T cell-regulated tumor ferroptosis

BackgroundCheckpoint blockade therapies have transformed the landscape of cancer care. Durable clinical responses have been observed in a subset of patients. However, many patients do not respond, and understanding the mechanisms that determine tumor resistant to checkpoint blockade drugs could pote...

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Veröffentlicht in:	Journal for immunotherapy of cancer 2020-11, Vol.8 (Suppl 3), p.A142-A142
Hauptverfasser:	Gajewski, Thomas, Higgs, Emily, Li, Shuyin, Flood, Blake, Hatogai, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Ferroptosis Immunotherapy Lymphocytes Reactive oxygen species Tumors
Online-Zugang:	Volltext
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