Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine

BackgroundWhile prophylactic human papillomavirus (HPV) vaccines will certainly reduce the incidence of HPV-associated cancers, these malignancies remain a major health issue. PDS0101 is a liposomal-based HPV therapeutic vaccine consisting of the immune activating cationic lipid R-DOTAP and HLA-unre...

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Veröffentlicht in:	Journal for immunotherapy of cancer 2020-06, Vol.8 (1), p.e000612
Hauptverfasser:	Smalley Rumfield, Claire, Pellom, Samuel T, Morillon II, Y Maurice, Schlom, Jeffrey, Jochems, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Apoptosis Cancer Cancer therapies Cervical cancer Clinical trials Clinical/Translational Cancer Immunotherapy Genital cancers genital Neoplasms, female Head & neck cancer head and neck neoplasms Human papillomavirus Immunotherapy Infections Laboratory animals Lipids Lymphocytes Patients Peptides Proteins R&D Research & development Response rates therapies, investigational Tumors vaccination Vaccines
Online-Zugang:	Volltext
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