Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome

Monomer tubulin polymerize into microtubules, which are highly dynamic and play a critical role in mitosis. Therefore, microtubule dynamics are an important target for anticancer drugs. The inhibition of tubulin polymerization or depolymerization was previously targeted and exhibited efficacy agains...

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Veröffentlicht in:	Cancer science 2020-12, Vol.111 (12), p.4336-4347
Hauptverfasser:	Zhong, Cheng, Kayamori, Kensuke, Koide, Shuhei, Shinoda, Daisuke, Oshima, Motohiko, Nakajima‐Takagi, Yaeko, Nagai, Yurie, Mimura, Naoya, Sakaida, Emiko, Yamazaki, Satoshi, Iwano, Satoshi, Miyawaki, Atsushi, Ito, Ryoji, Tohyama, Kaoru, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Lennox, William, Sheedy, Josephine, Weetall, Marla, Iwama, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Acute myeloid leukemia Animal models Animals Antimetabolites, Antineoplastic - pharmacology Antineoplastic drugs Antitumor agents Apoptosis Apoptosis - drug effects Apoptosis - genetics Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Binding sites Bioluminescence Blood Cancer Care and treatment Cell cycle Cell death Cell division Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects chemotherapy Cytotoxicity Decitabine - pharmacology Deoxyribonucleic acid Depolymerization DNA DNA hypomethylating agents DNA methylation FDA approval G2 Phase - drug effects Gene expression Genomes Hematology Heterografts HL-60 Cells Humans Laboratory animals Leukemia Life Sciences & Biomedicine Mice Microtubules Mitosis Myelodysplastic syndrome Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - genetics Myeloid leukemia Oncology Original Ovarian cancer p53 Protein Paclitaxel - pharmacology Polymerization Pyrazines - pharmacology Pyrazines - therapeutic use Science & Technology Sequence Analysis, RNA - methods Software Solid tumors Tubulin Tubulin - drug effects Tubulin Modulators - pharmacology Tubulin Modulators - therapeutic use Tubulin polymerization inhibitor Tubulins Tumor proteins Vincristine Vincristine - pharmacology Xenografts
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