One‐Pot Oxidation of Secondary Alcohols to α‐Hydroxy Ketones: Application to Synthesis of Oxoaplysinopsin D, E, F, & G

A simple one‐pot transformation of secondary alcohols to α‐hydroxy ketones using pyridinium dichromate (PDC) in DMF has been developed and substrate scope tested with 25 compounds of hydantoin derivatives. Using this method, we have devised a common dihydroxy intermediate and synthesized four natura...

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Veröffentlicht in:	European journal of organic chemistry 2021-04, Vol.2021 (15), p.2188-2192
Hauptverfasser:	Kulkarni, Akshay S., Ramesh, Eagala, Srinivasa Reddy, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Chromates Hydantoin Ketones Natural product Natural products Oxidation Oxoaplysinopsin Retro-aldol Substrates α-Hydroxylation
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