Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices
The immunohistochemical expression of cathepsin D was performed in paraffin embedded tissue from 79 endometrial carcinomas, 35 cases of hyperplasia, and 32 normal endometrium using the streptavidin-biotin method to investigate the role of cathepsin D (CD) in these lesions and its possible relationsh...
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| Veröffentlicht in: | International journal of gynecological cancer 2003-05, Vol.13 (3), p.344-351 |
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| creator | IOACHIM, E. KITSIOU, E. CHARALABOPOULOS, K. MITSELOU, A. ZAGORIANAKOU, N. MAKRYDIMAS, G. TZIORAS, S. SALMAS, M. |
| description | The immunohistochemical expression of cathepsin D was performed in paraffin embedded tissue from 79 endometrial carcinomas, 35 cases of hyperplasia, and 32 normal endometrium using the streptavidin-biotin method to investigate the role of cathepsin D (CD) in these lesions and its possible relationship with other potential and established prognostic markers. The association between CD and the other markers was assessed by univariate analysis. Tumor cell CD expression was lower in the group of carcinomas compared to the normal proliferative (P = 0.022) and secretory endometrium (P = 0.0005). In addition, hyperplastic cell CD expression was lower compared with epithelial cell CD expression in the secretory phase of normal endometrium (P = 0.009). Malignant cell CD expression was inversely correlated with tumor stromal cells (P = 0.007). A positive relationship of stromal cell CD expression with pRb (P = 0.046) and PCNA score (P < 0.0001) was detected in the group of carcinomas. In the proliferative phase of normal endometrium, epithelial CD expression was positively correlated with estrogen status (P = 0.015). The data show that down-regulation of CD expression is an early event in endometrial carcinogenesis. In addition, stromal cell CD expression may be involved in cell growth process in endometrial carcinomas. |
| doi_str_mv | 10.1136/ijgc-00009577-200305000-00014 |
| format | Article |
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The association between CD and the other markers was assessed by univariate analysis. Tumor cell CD expression was lower in the group of carcinomas compared to the normal proliferative (P = 0.022) and secretory endometrium (P = 0.0005). In addition, hyperplastic cell CD expression was lower compared with epithelial cell CD expression in the secretory phase of normal endometrium (P = 0.009). Malignant cell CD expression was inversely correlated with tumor stromal cells (P = 0.007). A positive relationship of stromal cell CD expression with pRb (P = 0.046) and PCNA score (P < 0.0001) was detected in the group of carcinomas. In the proliferative phase of normal endometrium, epithelial CD expression was positively correlated with estrogen status (P = 0.015). The data show that down-regulation of CD expression is an early event in endometrial carcinogenesis. In addition, stromal cell CD expression may be involved in cell growth process in endometrial carcinomas.</description><identifier>ISSN: 1048-891X</identifier><identifier>EISSN: 1525-1438</identifier><identifier>DOI: 10.1136/ijgc-00009577-200305000-00014</identifier><identifier>PMID: 12801267</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Adult ; Cancer ; Carcinoma, Endometrioid - immunology ; Carcinoma, Endometrioid - pathology ; Cathepsin D - biosynthesis ; Cathepsin D - immunology ; Cell Transformation, Neoplastic - immunology ; Endometrial cancer ; Endometrial Hyperplasia - immunology ; Endometrial Hyperplasia - pathology ; Endometrial Neoplasms - immunology ; Endometrial Neoplasms - pathology ; Endometrium ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Neoplasm Proteins - immunology ; Neoplasm Staging ; Nuclear Proteins - immunology ; Precancerous Conditions - immunology ; Precancerous Conditions - pathology ; Prognosis ; Receptors, Steroid - immunology</subject><ispartof>International journal of gynecological cancer, 2003-05, Vol.13 (3), p.344-351</ispartof><rights>2003 IGCS</rights><rights>2003 2003 IGCS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b1857-dbf07d6e5b2d45176e1e5351d2335f541cf2da958436ea642195ddf6ca081a653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12801267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IOACHIM, E.</creatorcontrib><creatorcontrib>KITSIOU, E.</creatorcontrib><creatorcontrib>CHARALABOPOULOS, K.</creatorcontrib><creatorcontrib>MITSELOU, A.</creatorcontrib><creatorcontrib>ZAGORIANAKOU, N.</creatorcontrib><creatorcontrib>MAKRYDIMAS, G.</creatorcontrib><creatorcontrib>TZIORAS, S.</creatorcontrib><creatorcontrib>SALMAS, M.</creatorcontrib><title>Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices</title><title>International journal of gynecological cancer</title><addtitle>Int J Gynecol Cancer</addtitle><description>The immunohistochemical expression of cathepsin D was performed in paraffin embedded tissue from 79 endometrial carcinomas, 35 cases of hyperplasia, and 32 normal endometrium using the streptavidin-biotin method to investigate the role of cathepsin D (CD) in these lesions and its possible relationship with other potential and established prognostic markers. The association between CD and the other markers was assessed by univariate analysis. Tumor cell CD expression was lower in the group of carcinomas compared to the normal proliferative (P = 0.022) and secretory endometrium (P = 0.0005). In addition, hyperplastic cell CD expression was lower compared with epithelial cell CD expression in the secretory phase of normal endometrium (P = 0.009). Malignant cell CD expression was inversely correlated with tumor stromal cells (P = 0.007). A positive relationship of stromal cell CD expression with pRb (P = 0.046) and PCNA score (P < 0.0001) was detected in the group of carcinomas. In the proliferative phase of normal endometrium, epithelial CD expression was positively correlated with estrogen status (P = 0.015). The data show that down-regulation of CD expression is an early event in endometrial carcinogenesis. In addition, stromal cell CD expression may be involved in cell growth process in endometrial carcinomas.</description><subject>Adult</subject><subject>Cancer</subject><subject>Carcinoma, Endometrioid - immunology</subject><subject>Carcinoma, Endometrioid - pathology</subject><subject>Cathepsin D - biosynthesis</subject><subject>Cathepsin D - immunology</subject><subject>Cell Transformation, Neoplastic - immunology</subject><subject>Endometrial cancer</subject><subject>Endometrial Hyperplasia - immunology</subject><subject>Endometrial Hyperplasia - pathology</subject><subject>Endometrial Neoplasms - immunology</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrium</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - immunology</subject><subject>Neoplasm Staging</subject><subject>Nuclear Proteins - immunology</subject><subject>Precancerous Conditions - immunology</subject><subject>Precancerous Conditions - pathology</subject><subject>Prognosis</subject><subject>Receptors, Steroid - immunology</subject><issn>1048-891X</issn><issn>1525-1438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqVkcuKFTEQhoMozjj6ChIQdyeaS6cvgovxeBsYEETBXUgn1dM5dCdtklbmEX0rc6aPujaLJFX8_1cFP0LPGX3BmKhfusONIbScTjYN4ZQKKkt1bLHqHjpnkkvCKtHeL39ataTt2Lcz9Cilw9HEafcQnTHeUsbr5hz9uprn1YfRpRzMCLMzesLwQ0-rzi54HAZsdB5hSc7jt7hcPsRZTzs83i4Ql0mn7AzW3uLSdTde-4zB2zBDjm6dX-F9iBGmjfbT5RGPBRA84AgGlhwiTlnnNWFDIPZvCN_hRYod_tzjJYYMzqc7fCkmN0DcSDqlYJzOYMtO1hlIj9GDQU8JnpzeC_T1_bsv-4_k-tOHq_3lNelZKxti-4E2tgbZc1tJ1tTAQArJLBdCDrJiZuBWd7KtRA26rjjrpLVDbTRtma6luEDPNm5Z6PsKKatDWKMvIxWXkjddTWVbVK83lYkhpQiDWqKbdbxVjKpjkOoYpPoTpPobpLoLsvifnqas_Qz2n_uUXBG0m6CfD__J_g3bV68D</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>IOACHIM, E.</creator><creator>KITSIOU, E.</creator><creator>CHARALABOPOULOS, K.</creator><creator>MITSELOU, A.</creator><creator>ZAGORIANAKOU, N.</creator><creator>MAKRYDIMAS, G.</creator><creator>TZIORAS, S.</creator><creator>SALMAS, M.</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200305</creationdate><title>Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices</title><author>IOACHIM, E. ; KITSIOU, E. ; CHARALABOPOULOS, K. ; MITSELOU, A. ; ZAGORIANAKOU, N. ; MAKRYDIMAS, G. ; TZIORAS, S. ; SALMAS, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1857-dbf07d6e5b2d45176e1e5351d2335f541cf2da958436ea642195ddf6ca081a653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Cancer</topic><topic>Carcinoma, Endometrioid - immunology</topic><topic>Carcinoma, Endometrioid - pathology</topic><topic>Cathepsin D - biosynthesis</topic><topic>Cathepsin D - immunology</topic><topic>Cell Transformation, Neoplastic - immunology</topic><topic>Endometrial cancer</topic><topic>Endometrial Hyperplasia - immunology</topic><topic>Endometrial Hyperplasia - pathology</topic><topic>Endometrial Neoplasms - immunology</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrium</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - immunology</topic><topic>Neoplasm Staging</topic><topic>Nuclear Proteins - immunology</topic><topic>Precancerous Conditions - immunology</topic><topic>Precancerous Conditions - pathology</topic><topic>Prognosis</topic><topic>Receptors, Steroid - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IOACHIM, E.</creatorcontrib><creatorcontrib>KITSIOU, E.</creatorcontrib><creatorcontrib>CHARALABOPOULOS, K.</creatorcontrib><creatorcontrib>MITSELOU, A.</creatorcontrib><creatorcontrib>ZAGORIANAKOU, N.</creatorcontrib><creatorcontrib>MAKRYDIMAS, G.</creatorcontrib><creatorcontrib>TZIORAS, S.</creatorcontrib><creatorcontrib>SALMAS, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of gynecological cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IOACHIM, E.</au><au>KITSIOU, E.</au><au>CHARALABOPOULOS, K.</au><au>MITSELOU, A.</au><au>ZAGORIANAKOU, N.</au><au>MAKRYDIMAS, G.</au><au>TZIORAS, S.</au><au>SALMAS, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices</atitle><jtitle>International journal of gynecological cancer</jtitle><addtitle>Int J Gynecol Cancer</addtitle><date>2003-05</date><risdate>2003</risdate><volume>13</volume><issue>3</issue><spage>344</spage><epage>351</epage><pages>344-351</pages><issn>1048-891X</issn><eissn>1525-1438</eissn><abstract>The immunohistochemical expression of cathepsin D was performed in paraffin embedded tissue from 79 endometrial carcinomas, 35 cases of hyperplasia, and 32 normal endometrium using the streptavidin-biotin method to investigate the role of cathepsin D (CD) in these lesions and its possible relationship with other potential and established prognostic markers. The association between CD and the other markers was assessed by univariate analysis. Tumor cell CD expression was lower in the group of carcinomas compared to the normal proliferative (P = 0.022) and secretory endometrium (P = 0.0005). In addition, hyperplastic cell CD expression was lower compared with epithelial cell CD expression in the secretory phase of normal endometrium (P = 0.009). Malignant cell CD expression was inversely correlated with tumor stromal cells (P = 0.007). A positive relationship of stromal cell CD expression with pRb (P = 0.046) and PCNA score (P < 0.0001) was detected in the group of carcinomas. In the proliferative phase of normal endometrium, epithelial CD expression was positively correlated with estrogen status (P = 0.015). The data show that down-regulation of CD expression is an early event in endometrial carcinogenesis. In addition, stromal cell CD expression may be involved in cell growth process in endometrial carcinomas.</abstract><cop>England</cop><pub>Elsevier Limited</pub><pmid>12801267</pmid><doi>10.1136/ijgc-00009577-200305000-00014</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Cancer Carcinoma, Endometrioid - immunology Carcinoma, Endometrioid - pathology Cathepsin D - biosynthesis Cathepsin D - immunology Cell Transformation, Neoplastic - immunology Endometrial cancer Endometrial Hyperplasia - immunology Endometrial Hyperplasia - pathology Endometrial Neoplasms - immunology Endometrial Neoplasms - pathology Endometrium Female Humans Immunohistochemistry Middle Aged Neoplasm Proteins - immunology Neoplasm Staging Nuclear Proteins - immunology Precancerous Conditions - immunology Precancerous Conditions - pathology Prognosis Receptors, Steroid - immunology |
| title | Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices |
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