4CPS-301 Association of antibiotics and proton pump inhibitors on clinical activity of firstline pembrolizumab for non-small cell lung cancer: 2 years of real world data

Background and importanceThe gut microbiome plays a dominant role in modulating the therapeutic efficacy of immune checkpoint inhibitors (ICIs). The use of proton pump inhibitors (PPI) and antibiotics (ATB) can induce dysbacteriosis, which may attenuate the clinical outcomes of ICIs, as shown in pre...

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Veröffentlicht in:	European journal of hospital pharmacy. Science and practice 2021-03, Vol.28 (Suppl 1), p.A65-A65
Hauptverfasser:	A Castro Balado, Lores, M Tourís, R Álvarez Sánchez, B Bernárdez Ferrán, E López Montero, A Mosquera Torre, B Mejuto Pérez Del Molino, Ferro, I Zarra
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Clinical outcomes Conflicts of interest Immunotherapy Lung cancer Metastasis Monoclonal antibodies Multivariate analysis Targeted cancer therapy
Online-Zugang:	Volltext
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