$LY3022855, an anti–colony stimulating factor-1 receptor (CSF-1R) monoclonal antibody, in patients with advanced solid tumors refractory to standard therapy: phase 1 dose-escalation trial$

LY3022855, an anti–colony stimulating factor-1 receptor (CSF-1R) monoclonal antibody, in patients with advanced solid tumors refractory to standard therapy: phase 1 dose-escalation trial

Summary Background Tumor-associated macrophages (TAMs) promote tumor growth, metastasis, and therapeutic resistance via colony-stimulating factor-1 (CSF-1), acting through CSF-1 receptor (CSF-1R) signaling. This phase 1 study determined the safety, tolerability, pharmacokinetics-pharmacodynamics, im...

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Veröffentlicht in:	Investigational new drugs 2021-08, Vol.39 (4), p.1057-1071
Hauptverfasser:	Dowlati, Afshin, Harvey, R. Donald, Carvajal, Richard D., Hamid, Omid, Klempner, Samuel J., Kauh, John Sae Wook, Peterson, Daniel A., Yu, Danni, Chapman, Sonya C., Szpurka, Anna M., Carlsen, Michelle, Quinlan, Tonya, Wesolowski, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adolescent Adult Adverse events Aged Anemia Anorexia Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Cohort Studies Colonies Colony-stimulating factor Diarrhea Dosage Dose-Response Relationship, Drug Female Fever Heart Humans Immunogenicity Immunotherapy Intravenous administration L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Macrophage colony-stimulating factor Macrophages Male Mathematical analysis Medicine Medicine & Public Health Metastases Middle Aged Monoclonal antibodies Nausea Neoplasms - drug therapy Oncology Pancreatitis Patients Pharmacodynamics Pharmacokinetics Pharmacology Pharmacology/Toxicology Phase I Studies Receptors Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Resistance factors Rhabdomyolysis Solid tumors Toxicity Tumors Ventricle Vomiting Weight Young Adult
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