Application of an In Vitro Psoriatic Skin Model to Study Cutaneous Metabolization of Tazarotene

Psoriasis is an inflammatory skin disease characterized by the presence of whitish and scaly plaques, which can cover up to 90% of the body surface. These plaques result from the hyperproliferation and abnormal differentiation of keratinocytes. Dermopharmaceutical testing of new therapies is limited...

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Veröffentlicht in:	Processes 2019-12, Vol.7 (12), p.871
Hauptverfasser:	Morin, Alexandre, Simard, Mélissa, Rioux, Geneviève, Grenier, Alexe, Morin, Sophie, Pouliot, Roxane
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Acids Biopsy Cell culture Dermis Epidermis Fibroblasts Gene expression Immunofluorescence In vivo methods and tests Keratinocytes Liquid chromatography Medical research Metabolism Metabolites Mimicry Patients Phenotypes Plaques Psoriasis Self-assembly Skin Skin diseases Substitutes Tazarotene
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