Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L
Artemisia species are used as folk medicines in several countries. This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase α-amylase, and α-glucosidase) as well of their a...
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| creator | Ferrante, Claudio Zengin, Gokhan Menghini, Luigi Diuzheva, Alina Jekő, József Cziáky, Zoltán Recinella, Lucia Chiavaroli, Annalisa Leone, Sheila Brunetti, Luigi Lobine, Devina Senkardes, Ismail Mahomoodally, Mohamad Fawzi Orlando, Giustino |
| description | Artemisia species are used as folk medicines in several countries. This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase α-amylase, and α-glucosidase) as well of their antioxidant and pharmacological effects. The chemical profile of the essential oil was determined using gas chromatography coupled to mass spectrometry (GC-MS) analysis, while the extracts were chemically characterized by high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Forty-nine constituents were identified and camphor (36.6%), 1,8-cineole (10.2%), α-thujone (10.1%), borneol (4.5%), and β-thujone (3.6%) were the major components. Overall, 45, 74, and 67 components were identified from the ethyl acetate, methanol, and water extracts, respectively. The EO and extracts showed significant antioxidant properties, in a cell-free model; particularly, methanol and water extracts revealed promising sources of antioxidant compounds. Additionally, we evaluated protective effects of EO and extracts in isolated rat colon tissue challenged with lipopolysaccharide (LPS), as an ex vivo model of colon inflammation, and human colon cancer HCT116 cell line. Particularly, we observed that, among all tested samples, A. santonicum ethyl acetate displayed the best pharmacological profile, being able to blunt LPS-induced levels of all tested biomarkers of inflammation and oxidative stress, including colon nitrites, lactate dehydrogenase, prostaglandin E2, and serotonin. Additionally, this extract was also able to reduce HCT116 cell viability, thus suggesting potential antiproliferative effects against colon cancer cells. Based on our results, A. santonicum has great potential for developing novel functional agents including pharmaceuticals, cosmeceuticals, and nutraceuticals. |
| doi_str_mv | 10.3390/pr7080522 |
| format | Article |
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This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase α-amylase, and α-glucosidase) as well of their antioxidant and pharmacological effects. The chemical profile of the essential oil was determined using gas chromatography coupled to mass spectrometry (GC-MS) analysis, while the extracts were chemically characterized by high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Forty-nine constituents were identified and camphor (36.6%), 1,8-cineole (10.2%), α-thujone (10.1%), borneol (4.5%), and β-thujone (3.6%) were the major components. Overall, 45, 74, and 67 components were identified from the ethyl acetate, methanol, and water extracts, respectively. The EO and extracts showed significant antioxidant properties, in a cell-free model; particularly, methanol and water extracts revealed promising sources of antioxidant compounds. Additionally, we evaluated protective effects of EO and extracts in isolated rat colon tissue challenged with lipopolysaccharide (LPS), as an ex vivo model of colon inflammation, and human colon cancer HCT116 cell line. Particularly, we observed that, among all tested samples, A. santonicum ethyl acetate displayed the best pharmacological profile, being able to blunt LPS-induced levels of all tested biomarkers of inflammation and oxidative stress, including colon nitrites, lactate dehydrogenase, prostaglandin E2, and serotonin. Additionally, this extract was also able to reduce HCT116 cell viability, thus suggesting potential antiproliferative effects against colon cancer cells. Based on our results, A. santonicum has great potential for developing novel functional agents including pharmaceuticals, cosmeceuticals, and nutraceuticals.</description><identifier>ISSN: 2227-9717</identifier><identifier>EISSN: 2227-9717</identifier><identifier>DOI: 10.3390/pr7080522</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Acetic acid ; Acids ; Antioxidants ; Bioassays ; Biomarkers ; Borneol ; Camphor ; Cell viability ; Cholinesterase ; Chromatography ; Cineole ; Colon ; Colon cancer ; Colorectal cancer ; Cosmeceuticals ; Enzymes ; Essential oils ; Ethyl acetate ; Flavonoids ; Functional foods & nutraceuticals ; Gas chromatography ; Glucosidase ; High performance liquid chromatography ; Inflammation ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Lipopolysaccharides ; Mass spectrometry ; Mass spectroscopy ; Methanol ; Nitrites ; Oils & fats ; Oxidative stress ; Pharmacology ; Prostaglandin E2 ; Qualitative analysis ; Serotonin ; Solvents ; Spectroscopy ; Statistical analysis ; Thujone ; Tyrosinase ; Variance analysis ; α-Amylase ; α-Glucosidase</subject><ispartof>Processes, 2019, Vol.7 (8), p.522</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c292t-87db554d1afc288237916b431ada2af50f19637de580b7a2736dd08f9d5b97523</citedby><cites>FETCH-LOGICAL-c292t-87db554d1afc288237916b431ada2af50f19637de580b7a2736dd08f9d5b97523</cites><orcidid>0000-0002-6398-0371 ; 0000-0001-9431-9407 ; 0000-0002-1846-3236 ; 0000-0003-3962-8666 ; 0000-0003-2090-1634 ; 0000-0002-7346-7395 ; 0000-0001-6548-7823</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Ferrante, Claudio</creatorcontrib><creatorcontrib>Zengin, Gokhan</creatorcontrib><creatorcontrib>Menghini, Luigi</creatorcontrib><creatorcontrib>Diuzheva, Alina</creatorcontrib><creatorcontrib>Jekő, József</creatorcontrib><creatorcontrib>Cziáky, Zoltán</creatorcontrib><creatorcontrib>Recinella, Lucia</creatorcontrib><creatorcontrib>Chiavaroli, Annalisa</creatorcontrib><creatorcontrib>Leone, Sheila</creatorcontrib><creatorcontrib>Brunetti, Luigi</creatorcontrib><creatorcontrib>Lobine, Devina</creatorcontrib><creatorcontrib>Senkardes, Ismail</creatorcontrib><creatorcontrib>Mahomoodally, Mohamad Fawzi</creatorcontrib><creatorcontrib>Orlando, Giustino</creatorcontrib><title>Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L</title><title>Processes</title><description>Artemisia species are used as folk medicines in several countries. This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase α-amylase, and α-glucosidase) as well of their antioxidant and pharmacological effects. The chemical profile of the essential oil was determined using gas chromatography coupled to mass spectrometry (GC-MS) analysis, while the extracts were chemically characterized by high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Forty-nine constituents were identified and camphor (36.6%), 1,8-cineole (10.2%), α-thujone (10.1%), borneol (4.5%), and β-thujone (3.6%) were the major components. Overall, 45, 74, and 67 components were identified from the ethyl acetate, methanol, and water extracts, respectively. The EO and extracts showed significant antioxidant properties, in a cell-free model; particularly, methanol and water extracts revealed promising sources of antioxidant compounds. Additionally, we evaluated protective effects of EO and extracts in isolated rat colon tissue challenged with lipopolysaccharide (LPS), as an ex vivo model of colon inflammation, and human colon cancer HCT116 cell line. Particularly, we observed that, among all tested samples, A. santonicum ethyl acetate displayed the best pharmacological profile, being able to blunt LPS-induced levels of all tested biomarkers of inflammation and oxidative stress, including colon nitrites, lactate dehydrogenase, prostaglandin E2, and serotonin. Additionally, this extract was also able to reduce HCT116 cell viability, thus suggesting potential antiproliferative effects against colon cancer cells. Based on our results, A. santonicum has great potential for developing novel functional agents including pharmaceuticals, cosmeceuticals, and nutraceuticals.</description><subject>Acetic acid</subject><subject>Acids</subject><subject>Antioxidants</subject><subject>Bioassays</subject><subject>Biomarkers</subject><subject>Borneol</subject><subject>Camphor</subject><subject>Cell viability</subject><subject>Cholinesterase</subject><subject>Chromatography</subject><subject>Cineole</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Cosmeceuticals</subject><subject>Enzymes</subject><subject>Essential oils</subject><subject>Ethyl acetate</subject><subject>Flavonoids</subject><subject>Functional foods & nutraceuticals</subject><subject>Gas chromatography</subject><subject>Glucosidase</subject><subject>High performance liquid chromatography</subject><subject>Inflammation</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate 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Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L</title><author>Ferrante, Claudio ; Zengin, Gokhan ; Menghini, Luigi ; Diuzheva, Alina ; Jekő, József ; Cziáky, Zoltán ; Recinella, Lucia ; Chiavaroli, Annalisa ; Leone, Sheila ; Brunetti, Luigi ; Lobine, Devina ; Senkardes, Ismail ; Mahomoodally, Mohamad Fawzi ; Orlando, Giustino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-87db554d1afc288237916b431ada2af50f19637de580b7a2736dd08f9d5b97523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetic acid</topic><topic>Acids</topic><topic>Antioxidants</topic><topic>Bioassays</topic><topic>Biomarkers</topic><topic>Borneol</topic><topic>Camphor</topic><topic>Cell viability</topic><topic>Cholinesterase</topic><topic>Chromatography</topic><topic>Cineole</topic><topic>Colon</topic><topic>Colon 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Giustino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L</atitle><jtitle>Processes</jtitle><date>2019</date><risdate>2019</risdate><volume>7</volume><issue>8</issue><spage>522</spage><pages>522-</pages><issn>2227-9717</issn><eissn>2227-9717</eissn><abstract>Artemisia species are used as folk medicines in several countries. This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase α-amylase, and α-glucosidase) as well of their antioxidant and pharmacological effects. The chemical profile of the essential oil was determined using gas chromatography coupled to mass spectrometry (GC-MS) analysis, while the extracts were chemically characterized by high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Forty-nine constituents were identified and camphor (36.6%), 1,8-cineole (10.2%), α-thujone (10.1%), borneol (4.5%), and β-thujone (3.6%) were the major components. Overall, 45, 74, and 67 components were identified from the ethyl acetate, methanol, and water extracts, respectively. The EO and extracts showed significant antioxidant properties, in a cell-free model; particularly, methanol and water extracts revealed promising sources of antioxidant compounds. Additionally, we evaluated protective effects of EO and extracts in isolated rat colon tissue challenged with lipopolysaccharide (LPS), as an ex vivo model of colon inflammation, and human colon cancer HCT116 cell line. Particularly, we observed that, among all tested samples, A. santonicum ethyl acetate displayed the best pharmacological profile, being able to blunt LPS-induced levels of all tested biomarkers of inflammation and oxidative stress, including colon nitrites, lactate dehydrogenase, prostaglandin E2, and serotonin. Additionally, this extract was also able to reduce HCT116 cell viability, thus suggesting potential antiproliferative effects against colon cancer cells. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals |
| subjects | Acetic acid Acids Antioxidants Bioassays Biomarkers Borneol Camphor Cell viability Cholinesterase Chromatography Cineole Colon Colon cancer Colorectal cancer Cosmeceuticals Enzymes Essential oils Ethyl acetate Flavonoids Functional foods & nutraceuticals Gas chromatography Glucosidase High performance liquid chromatography Inflammation L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lipopolysaccharides Mass spectrometry Mass spectroscopy Methanol Nitrites Oils & fats Oxidative stress Pharmacology Prostaglandin E2 Qualitative analysis Serotonin Solvents Spectroscopy Statistical analysis Thujone Tyrosinase Variance analysis α-Amylase α-Glucosidase |
| title | Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L |
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