Therapeutic Targeting of the Leukaemia Microenvironment

In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are co...

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Veröffentlicht in:	International journal of molecular sciences 2021-06, Vol.22 (13), p.6888, Article 6888
Hauptverfasser:	Kuek, Vincent, Hughes, Anastasia M., Kotecha, Rishi S., Cheung, Laurence C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute myeloid leukemia Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biochemistry & Molecular Biology Biomedical materials Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism bone marrow microenvironment Bone remodeling Chemistry Chemistry, Multidisciplinary Chemokines Chemoresistance Chemotherapy Clinical trials Crosstalk CXCL12 protein CXCR4 protein Cytokines Cytotoxicity endothelial cell Endothelial cells Hematology Hematopoietic stem cells Homeostasis Humans Hypoxia Investigations leukaemia Leukemia Leukemia - drug therapy Leukemia - pathology Life Sciences & Biomedicine Medical prognosis mesenchymal stem cell Mesenchyme Microenvironments Mutation osteoblast osteoclast Osteoclasts Patients Permeability Physical Sciences Remission Review Risk groups Science & Technology Signal Transduction Stem cells Survival Therapeutic targets Tumor Microenvironment - drug effects Vascular endothelial growth factor Wnt protein β-Catenin
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