Cell-penetrating, amphipathic cyclic peptoids as molecular transporters for cargo delivery
Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. We demonstrated that macrocyclization, along with the introduction of hydrophobic residues, greatly enhanced cellular uptake of polyguanidine...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2021-07, Vol.57 (55), p.68-683 |
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creator | Kim, Hyun-Soo Lee, Yeongju Shin, Min Hyeon Lim, Hyun-Suk |
description | Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. We demonstrated that macrocyclization, along with the introduction of hydrophobic residues, greatly enhanced cellular uptake of polyguanidine linear peptoids. The amphipathic cyclic peptoids showed an order of magnitude more efficient intracellular delivery ability, compared to a commonly used polyarginine cell-penetrating peptide, representing one of the best molecular transporters reported to date. Given the excellent cell-permeability, proteolytic stability, and ease of synthesis, the amphipathic cyclic peptoids would be broadly applicable to a wide range of clinical and biological applications.
Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. |
doi_str_mv | 10.1039/d1cc02848k |
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Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d1cc02848k</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Synthesis</subject><ispartof>Chemical communications (Cambridge, England), 2021-07, Vol.57 (55), p.68-683</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-dc6cb461da7ec849bf1a2e3db492ece68a311351d3653ac1076af14cf35da86c3</citedby><cites>FETCH-LOGICAL-c314t-dc6cb461da7ec849bf1a2e3db492ece68a311351d3653ac1076af14cf35da86c3</cites><orcidid>0000-0003-4083-2998</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kim, Hyun-Soo</creatorcontrib><creatorcontrib>Lee, Yeongju</creatorcontrib><creatorcontrib>Shin, Min Hyeon</creatorcontrib><creatorcontrib>Lim, Hyun-Suk</creatorcontrib><title>Cell-penetrating, amphipathic cyclic peptoids as molecular transporters for cargo delivery</title><title>Chemical communications (Cambridge, England)</title><description>Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. We demonstrated that macrocyclization, along with the introduction of hydrophobic residues, greatly enhanced cellular uptake of polyguanidine linear peptoids. The amphipathic cyclic peptoids showed an order of magnitude more efficient intracellular delivery ability, compared to a commonly used polyarginine cell-penetrating peptide, representing one of the best molecular transporters reported to date. Given the excellent cell-permeability, proteolytic stability, and ease of synthesis, the amphipathic cyclic peptoids would be broadly applicable to a wide range of clinical and biological applications.
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title | Cell-penetrating, amphipathic cyclic peptoids as molecular transporters for cargo delivery |
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