Regulation of oligonucleotide adsorption by a thermo and pH dual-responsive copolymer layer

Oligonucleotides hold great promise as therapeutic agents to specifically and selectively inhibit gene expression. In order to achieve better targeting efficiency and treatment efficacy, nanocarriers that are dual-responsive to both temperature and pH are more attractive and suitable due to the fact...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2021-07, Vol.23 (26), p.14296-1437
Hauptverfasser:	Feng, Chao, Mu, Jiang-xue, Ren, Chun-lai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Chemical compounds Copolymers Design parameters Gene expression Graft copolymers Nanoparticles Oligonucleotides Pharmacology Polyethyleneimine Polyisopropyl acrylamide Surface chemistry Temperature Temperature effects
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