Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods

An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of several synthetic methods: (1) complexation-driven selective acyl migration/oxidation; (2) BSA-mediated cycli...

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Veröffentlicht in:	Chemical science (Cambridge) 2021-07, Vol.12 (26), p.931-936
Hauptverfasser:	Klapars, Artis, Chung, John Y. L, Limanto, John, Calabria, Ralph, Campeau, Louis-Charles, Campos, Kevin R, Chen, Wenyong, Dalby, Stephen M, Davis, Tyler A, DiRocco, Daniel A, Hyde, Alan M, Kassim, Amude M, Larsen, Mona Utne, Liu, Guiquan, Maligres, Peter E, Moment, Aaron, Peng, Feng, Ruck, Rebecca T, Shevlin, Michael, Simmons, Bryon L, Song, Zhiguo Jake, Tan, Lushi, Wright, Timothy J, Zultanski, Susan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Ferric chloride Hydrochlorination Nucleotides Oxidation Stereoselectivity Synthesis
Online-Zugang:	Volltext
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