Identification of Natural Products as Potential Pharmacological Chaperones for Protein Misfolding Diseases

Defective protein folding and accumulation of misfolded proteins is associated with neurodegenerative, cardiovascular, secretory, and metabolic disorders. Efforts are being made to identify small‐molecule modulators or structural‐correctors for conformationally destabilized proteins implicated in va...

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Veröffentlicht in:	ChemMedChem 2021-07, Vol.16 (13), p.2146-2156
Hauptverfasser:	Sharma, Richa, Srivastava, Tulika, Pandey, Alka Raj, Mishra, Tripti, Gupta, Bhagyashri, Reddy, Sabbu Sathish, Singh, Suriya P., Narender, Tadigoppula, Tripathi, Aradhya, Chandramouli, Balasubramanian, Sashidhara, Koneni V., Priya, Smriti, Kumar, Niti
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration aggregation alpha-Synuclein - antagonists & inhibitors alpha-Synuclein - metabolism Biological Products - chemistry Biological Products - isolation & purification Biological Products - pharmacology Cells, Cultured Chaperones Computational neuroscience Cytotoxicity Diseases Dose-Response Relationship, Drug Fibrils Flavone glycosides Flavonoids Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology HEK293 Cells Humans Metabolic disorders Modulators Molecular Structure Natural products Neurodegeneration Neuromodulation Oligomers pharmacological chaperones Pharmacology Protein folding Protein Folding - drug effects Protein interaction protein misfolding Proteins Proteostasis Deficiencies - drug therapy Proteostasis Deficiencies - metabolism Seeds - chemistry Structure-Activity Relationship Synuclein Trigonella - chemistry α-synuclein
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