Local treatment of metastases plus systemic chemotherapy on overall survival of patients with metastatic nasopharyngeal carcinoma
Background To investigate the effect of local treatment of metastases on overall survival (OS) of patients with metastatic nasopharyngeal carcinoma (NPC). Methods One hundred and forty‐seven patients were included. The association between local treatment and OS was examined with propensity score mat...
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| Veröffentlicht in: | Head & neck 2021-08, Vol.43 (8), p.2423-2433 |
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| container_title | Head & neck |
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| creator | Liao, Wenjun He, Jinlan Gou, Qiheng Duan, Baofeng Ai, Ping Liu, Lei Li, Yanchu Ren, Kexing Yao, Min Chen, Nianyong |
| description | Background
To investigate the effect of local treatment of metastases on overall survival (OS) of patients with metastatic nasopharyngeal carcinoma (NPC).
Methods
One hundred and forty‐seven patients were included. The association between local treatment and OS was examined with propensity score matching (PSM) method.
Results
In entire cohort, the median OS was significantly longer in patients with local treatment of metastases plus chemotherapy compared to those with chemotherapy alone (71.7 vs. 16.2 months; p 60 Gy had longer OS than those who received less.
Conclusions
Local treatment of metastases could improve OS of patients with metastatic NPC and could be considered in their treatment in addition to chemotherapy. |
| doi_str_mv | 10.1002/hed.26706 |
| format | Article |
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To investigate the effect of local treatment of metastases on overall survival (OS) of patients with metastatic nasopharyngeal carcinoma (NPC).
Methods
One hundred and forty‐seven patients were included. The association between local treatment and OS was examined with propensity score matching (PSM) method.
Results
In entire cohort, the median OS was significantly longer in patients with local treatment of metastases plus chemotherapy compared to those with chemotherapy alone (71.7 vs. 16.2 months; p < 0.001). In PSM cohort, similar OS benefit of patients with local treatment was observed (55.6 vs. 17.6 months; p = 0.011). The survival benefit of local treatment remained regardless of the number of metastatic lesions and metastatic sites. Patients received radiation doses of >60 Gy had longer OS than those who received less.
Conclusions
Local treatment of metastases could improve OS of patients with metastatic NPC and could be considered in their treatment in addition to chemotherapy.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26706</identifier><identifier>PMID: 33939262</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Chemotherapy ; distant metastasis ; local treatment ; Metastases ; Metastasis ; Nasopharyngeal carcinoma ; radiotherapy ; Survival ; Throat cancer</subject><ispartof>Head & neck, 2021-08, Vol.43 (8), p.2423-2433</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC.</rights><rights>2021 The Authors. Head & Neck published by Wiley Periodicals LLC.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-61f4511538bd19a01522e77637d2b53732bdecf9814ba9be18745aea21fd2b5a3</citedby><cites>FETCH-LOGICAL-c3886-61f4511538bd19a01522e77637d2b53732bdecf9814ba9be18745aea21fd2b5a3</cites><orcidid>0000-0003-2299-1792 ; 0000-0002-0169-0926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26706$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26706$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33939262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Wenjun</creatorcontrib><creatorcontrib>He, Jinlan</creatorcontrib><creatorcontrib>Gou, Qiheng</creatorcontrib><creatorcontrib>Duan, Baofeng</creatorcontrib><creatorcontrib>Ai, Ping</creatorcontrib><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Li, Yanchu</creatorcontrib><creatorcontrib>Ren, Kexing</creatorcontrib><creatorcontrib>Yao, Min</creatorcontrib><creatorcontrib>Chen, Nianyong</creatorcontrib><title>Local treatment of metastases plus systemic chemotherapy on overall survival of patients with metastatic nasopharyngeal carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
To investigate the effect of local treatment of metastases on overall survival (OS) of patients with metastatic nasopharyngeal carcinoma (NPC).
Methods
One hundred and forty‐seven patients were included. The association between local treatment and OS was examined with propensity score matching (PSM) method.
Results
In entire cohort, the median OS was significantly longer in patients with local treatment of metastases plus chemotherapy compared to those with chemotherapy alone (71.7 vs. 16.2 months; p < 0.001). In PSM cohort, similar OS benefit of patients with local treatment was observed (55.6 vs. 17.6 months; p = 0.011). The survival benefit of local treatment remained regardless of the number of metastatic lesions and metastatic sites. Patients received radiation doses of >60 Gy had longer OS than those who received less.
Conclusions
Local treatment of metastases could improve OS of patients with metastatic NPC and could be considered in their treatment in addition to chemotherapy.</description><subject>Chemotherapy</subject><subject>distant metastasis</subject><subject>local treatment</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Nasopharyngeal carcinoma</subject><subject>radiotherapy</subject><subject>Survival</subject><subject>Throat cancer</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kE1Lw0AQhhdRbK0e_AOy4MlD2v3MJkfRaoWCFz2HTToxKUk27m5aevSfu7XtURiYYXnmmeVF6JaSKSWEzSpYTVmsSHyGxpSkKiJcqPP9LHjEiRIjdOXcmhDCY8Eu0YjzlKcsZmP0szSFbrC3oH0LncemxC147UKBw30zOOx2zkNbF7iooDW-Aqv7HTYdNpswNg12g93Um6AJy732dfA4vK19dVL5sNxpZ_pK2133BQEttC3qzrT6Gl2UunFwc-wT9Pky_3haRMv317enx2VU8CSJo5iWQlIqeZKvaKoJlYyBUjFXK5ZLrjjLV1CUaUJFrtMcaKKE1KAZLfeA5hN0f_D21nwP4Hy2NoPtwsmMSZFIEgspA_VwoAprnLNQZr2t2_DrjJJsH3YWws7-wg7s3dE45G14PZGndAMwOwDbuoHd_6ZsMX8-KH8BwOKLhg</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Liao, Wenjun</creator><creator>He, Jinlan</creator><creator>Gou, Qiheng</creator><creator>Duan, Baofeng</creator><creator>Ai, Ping</creator><creator>Liu, Lei</creator><creator>Li, Yanchu</creator><creator>Ren, Kexing</creator><creator>Yao, Min</creator><creator>Chen, Nianyong</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-2299-1792</orcidid><orcidid>https://orcid.org/0000-0002-0169-0926</orcidid></search><sort><creationdate>202108</creationdate><title>Local treatment of metastases plus systemic chemotherapy on overall survival of patients with metastatic nasopharyngeal carcinoma</title><author>Liao, Wenjun ; He, Jinlan ; Gou, Qiheng ; Duan, Baofeng ; Ai, Ping ; Liu, Lei ; Li, Yanchu ; Ren, Kexing ; Yao, Min ; Chen, Nianyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-61f4511538bd19a01522e77637d2b53732bdecf9814ba9be18745aea21fd2b5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chemotherapy</topic><topic>distant metastasis</topic><topic>local treatment</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Nasopharyngeal carcinoma</topic><topic>radiotherapy</topic><topic>Survival</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Wenjun</creatorcontrib><creatorcontrib>He, Jinlan</creatorcontrib><creatorcontrib>Gou, Qiheng</creatorcontrib><creatorcontrib>Duan, Baofeng</creatorcontrib><creatorcontrib>Ai, Ping</creatorcontrib><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Li, Yanchu</creatorcontrib><creatorcontrib>Ren, Kexing</creatorcontrib><creatorcontrib>Yao, Min</creatorcontrib><creatorcontrib>Chen, Nianyong</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Wenjun</au><au>He, Jinlan</au><au>Gou, Qiheng</au><au>Duan, Baofeng</au><au>Ai, Ping</au><au>Liu, Lei</au><au>Li, Yanchu</au><au>Ren, Kexing</au><au>Yao, Min</au><au>Chen, Nianyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local treatment of metastases plus systemic chemotherapy on overall survival of patients with metastatic nasopharyngeal carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2021-08</date><risdate>2021</risdate><volume>43</volume><issue>8</issue><spage>2423</spage><epage>2433</epage><pages>2423-2433</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
To investigate the effect of local treatment of metastases on overall survival (OS) of patients with metastatic nasopharyngeal carcinoma (NPC).
Methods
One hundred and forty‐seven patients were included. The association between local treatment and OS was examined with propensity score matching (PSM) method.
Results
In entire cohort, the median OS was significantly longer in patients with local treatment of metastases plus chemotherapy compared to those with chemotherapy alone (71.7 vs. 16.2 months; p < 0.001). In PSM cohort, similar OS benefit of patients with local treatment was observed (55.6 vs. 17.6 months; p = 0.011). The survival benefit of local treatment remained regardless of the number of metastatic lesions and metastatic sites. Patients received radiation doses of >60 Gy had longer OS than those who received less.
Conclusions
Local treatment of metastases could improve OS of patients with metastatic NPC and could be considered in their treatment in addition to chemotherapy.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33939262</pmid><doi>10.1002/hed.26706</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2299-1792</orcidid><orcidid>https://orcid.org/0000-0002-0169-0926</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Chemotherapy distant metastasis local treatment Metastases Metastasis Nasopharyngeal carcinoma radiotherapy Survival Throat cancer |
| title | Local treatment of metastases plus systemic chemotherapy on overall survival of patients with metastatic nasopharyngeal carcinoma |
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